Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis
Background: A number of studies examined the association between preterm delivery and kidney size and function later in life. However, the number of cases in published cohort studies is low. This study was aimed at performing a multicenter collaboration to pool data to obtain more accurate results t...
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Format: | Article |
Language: | English |
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Karger Publishers
2019-09-01
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Series: | Kidney & Blood Pressure Research |
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Online Access: | https://www.karger.com/Article/FullText/502715 |
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author | Maja Gilarska Anke Raaijmakers Zhen-Yu Zhang Jan A. Staessen Elena Levtchenko Małgorzata Klimek Andrzej Grudzień Katarzyna Starzec Karel Allegaert Przemko Kwinta |
author_facet | Maja Gilarska Anke Raaijmakers Zhen-Yu Zhang Jan A. Staessen Elena Levtchenko Małgorzata Klimek Andrzej Grudzień Katarzyna Starzec Karel Allegaert Przemko Kwinta |
author_sort | Maja Gilarska |
collection | DOAJ |
description | Background: A number of studies examined the association between preterm delivery and kidney size and function later in life. However, the number of cases in published cohort studies is low. This study was aimed at performing a multicenter collaboration to pool data to obtain more accurate results to quantify the extent of renal impairment in former extremely low birth weight (ELBW; <1,000 g) children. Methodology: We performed a subject-level meta-analysis to pool data from Cracow (64 cases/34 controls) and Leuven (93 cases/87 controls). We assessed and analyzed cystatin C, estimated glomerular filtration rate (eGFR), ultrasound kidney length, and blood pressure (BP) in 11-year-old ELBW children compared with controls born at term. The prevalence of hypertension (HT) and prehypertension (preHT) in both groups was also analyzed. Results: The study group comprised 157 former ELBW children (gestational age 23–33 weeks and birth weight 430–1,000 g) and 123 children born at term. Former ELBW children had lower mean eGFR (100.62 ± 16.53 vs. 111.89 ± 15.26 mL/min/1.73 m2; p < 0.001), smaller absolute kidney length (8.56 ± 0.78 vs. 9.008 ± 0.73 cm; <0.001), and higher systolic (111.8 ± 9.8 vs. 107.2 ± 9.07 mm Hg; p = 0.01) and diastolic (68.6 ± 6.8 vs. 66.3 ± 7.7 mm Hg; p = 0.03) BP. Smaller renal size in former ELBW children was positively associated with lower birth weight, shorter gestational age, and severity of perinatal complications (intraventricular hemorrhage, length of stay, mechanical ventilation, and oxygen therapy). Conclusion: ELBW is associated with lower eGFR and a high frequency of preHT and HT. |
first_indexed | 2024-04-13T16:58:26Z |
format | Article |
id | doaj.art-2163f3f3a00640449843c79e08cc3d3e |
institution | Directory Open Access Journal |
issn | 1420-4096 1423-0143 |
language | English |
last_indexed | 2024-04-13T16:58:26Z |
publishDate | 2019-09-01 |
publisher | Karger Publishers |
record_format | Article |
series | Kidney & Blood Pressure Research |
spelling | doaj.art-2163f3f3a00640449843c79e08cc3d3e2022-12-22T02:38:44ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432019-09-0144589790610.1159/000502715502715Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled AnalysisMaja GilarskaAnke RaaijmakersZhen-Yu ZhangJan A. StaessenElena LevtchenkoMałgorzata KlimekAndrzej GrudzieńKatarzyna StarzecKarel AllegaertPrzemko KwintaBackground: A number of studies examined the association between preterm delivery and kidney size and function later in life. However, the number of cases in published cohort studies is low. This study was aimed at performing a multicenter collaboration to pool data to obtain more accurate results to quantify the extent of renal impairment in former extremely low birth weight (ELBW; <1,000 g) children. Methodology: We performed a subject-level meta-analysis to pool data from Cracow (64 cases/34 controls) and Leuven (93 cases/87 controls). We assessed and analyzed cystatin C, estimated glomerular filtration rate (eGFR), ultrasound kidney length, and blood pressure (BP) in 11-year-old ELBW children compared with controls born at term. The prevalence of hypertension (HT) and prehypertension (preHT) in both groups was also analyzed. Results: The study group comprised 157 former ELBW children (gestational age 23–33 weeks and birth weight 430–1,000 g) and 123 children born at term. Former ELBW children had lower mean eGFR (100.62 ± 16.53 vs. 111.89 ± 15.26 mL/min/1.73 m2; p < 0.001), smaller absolute kidney length (8.56 ± 0.78 vs. 9.008 ± 0.73 cm; <0.001), and higher systolic (111.8 ± 9.8 vs. 107.2 ± 9.07 mm Hg; p = 0.01) and diastolic (68.6 ± 6.8 vs. 66.3 ± 7.7 mm Hg; p = 0.03) BP. Smaller renal size in former ELBW children was positively associated with lower birth weight, shorter gestational age, and severity of perinatal complications (intraventricular hemorrhage, length of stay, mechanical ventilation, and oxygen therapy). Conclusion: ELBW is associated with lower eGFR and a high frequency of preHT and HT.https://www.karger.com/Article/FullText/502715Extremely low birth weightCystatin CRenal complicationsHypertension |
spellingShingle | Maja Gilarska Anke Raaijmakers Zhen-Yu Zhang Jan A. Staessen Elena Levtchenko Małgorzata Klimek Andrzej Grudzień Katarzyna Starzec Karel Allegaert Przemko Kwinta Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis Kidney & Blood Pressure Research Extremely low birth weight Cystatin C Renal complications Hypertension |
title | Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis |
title_full | Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis |
title_fullStr | Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis |
title_full_unstemmed | Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis |
title_short | Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis |
title_sort | extremely low birth weight predisposes to impaired renal health a pooled analysis |
topic | Extremely low birth weight Cystatin C Renal complications Hypertension |
url | https://www.karger.com/Article/FullText/502715 |
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