The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
The extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition and assembly strongly affect cellular function an...
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| Format: | Article |
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MDPI AG
2020-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/2/394 |
| _version_ | 1797720468033110016 |
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| author | Ana Margarida Moreira Joana Pereira Soraia Melo Maria Sofia Fernandes Patrícia Carneiro Raquel Seruca Joana Figueiredo |
| author_facet | Ana Margarida Moreira Joana Pereira Soraia Melo Maria Sofia Fernandes Patrícia Carneiro Raquel Seruca Joana Figueiredo |
| author_sort | Ana Margarida Moreira |
| collection | DOAJ |
| description | The extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition and assembly strongly affect cellular function and behavior. Even though the detailed mechanisms underlying cell-ECM crosstalk are yet to unravel, it is well established that ECM deregulation accompanies the development of many pathological conditions, such as gastric cancer. Notably, gastric cancer remains a worldwide concern, representing the third most frequent cause of cancer-associated deaths. Despite increased surveillance protocols, patients are usually diagnosed at advanced disease stages, urging the identification of novel diagnostic biomarkers and efficient therapeutic strategies. In this review, we provide a comprehensive overview regarding expression patterns of ECM components and cognate receptors described in normal gastric epithelium, pre-malignant lesions, and gastric carcinomas. Important insights are also discussed for the use of ECM-associated molecules as predictive biomarkers of the disease or as potential targets in gastric cancer. |
| first_indexed | 2024-03-12T09:19:54Z |
| format | Article |
| id | doaj.art-2164fa638ad2493d935dbe6d0c5214a0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T09:19:54Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2164fa638ad2493d935dbe6d0c5214a02023-09-02T14:33:42ZengMDPI AGCells2073-44092020-02-019239410.3390/cells9020394cells9020394The Extracellular Matrix: An Accomplice in Gastric Cancer Development and ProgressionAna Margarida Moreira0Joana Pereira1Soraia Melo2Maria Sofia Fernandes3Patrícia Carneiro4Raquel Seruca5Joana Figueiredo6Epithelial Interactions in Cancer Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, PortugalEpithelial Interactions in Cancer Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, PortugalEpithelial Interactions in Cancer Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, PortugalEpithelial Interactions in Cancer Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, PortugalEpithelial Interactions in Cancer Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, PortugalEpithelial Interactions in Cancer Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, PortugalEpithelial Interactions in Cancer Group, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, PortugalThe extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition and assembly strongly affect cellular function and behavior. Even though the detailed mechanisms underlying cell-ECM crosstalk are yet to unravel, it is well established that ECM deregulation accompanies the development of many pathological conditions, such as gastric cancer. Notably, gastric cancer remains a worldwide concern, representing the third most frequent cause of cancer-associated deaths. Despite increased surveillance protocols, patients are usually diagnosed at advanced disease stages, urging the identification of novel diagnostic biomarkers and efficient therapeutic strategies. In this review, we provide a comprehensive overview regarding expression patterns of ECM components and cognate receptors described in normal gastric epithelium, pre-malignant lesions, and gastric carcinomas. Important insights are also discussed for the use of ECM-associated molecules as predictive biomarkers of the disease or as potential targets in gastric cancer.https://www.mdpi.com/2073-4409/9/2/394gastric cancerextracellular matrixintegrincell-ecm interactionecm deregulationecm targetingecm biomarkers |
| spellingShingle | Ana Margarida Moreira Joana Pereira Soraia Melo Maria Sofia Fernandes Patrícia Carneiro Raquel Seruca Joana Figueiredo The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression Cells gastric cancer extracellular matrix integrin cell-ecm interaction ecm deregulation ecm targeting ecm biomarkers |
| title | The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression |
| title_full | The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression |
| title_fullStr | The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression |
| title_full_unstemmed | The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression |
| title_short | The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression |
| title_sort | extracellular matrix an accomplice in gastric cancer development and progression |
| topic | gastric cancer extracellular matrix integrin cell-ecm interaction ecm deregulation ecm targeting ecm biomarkers |
| url | https://www.mdpi.com/2073-4409/9/2/394 |
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