The Role of Catechol-O-Methyltransferase (COMT) Gene in the Etiopathogenesis of Schizophrenia
Genetic factors in the risk of developing schizophrenia is of great importance. With the help of the advances in the field of genetics in recent years by using linkage analysis several genes have been identified that may be a risk factor in schizophrenia. Several association studies have been perfor...
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| Format: | Article |
| Language: | English |
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Psikiyatride Güncel Yaklaşımlar
2014-09-01
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| Series: | Psikiyatride Güncel Yaklaşımlar |
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| Online Access: | http://www.cappsy.org/archives/vol6/no3/cap_06_03_02.pdf |
| _version_ | 1797328967196213248 |
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| author | Ceren Acar sukru Kartalci |
| author_facet | Ceren Acar sukru Kartalci |
| author_sort | Ceren Acar |
| collection | DOAJ |
| description | Genetic factors in the risk of developing schizophrenia is of great importance. With the help of the advances in the field of genetics in recent years by using linkage analysis several genes have been identified that may be a risk factor in schizophrenia. Several association studies have been performed in many different populations on the candidate susceptibility genes that were defined in previous studies. However, these studies give controversial results in different countries with different populations, and there are problems in obtaining replicable results. In this review we aimed to focus on the genetic basis of schizophrenia and the relationship between schizophrenia and catechol-O-methyltransferase (COMT) gene. COMT encodes an enzyme molecule which has an important function in dopamine pathways. It has great importance in catecholamine metabolism and pharmacology and genetic mechanism of catechol metabolism variations and their clinical consequences. COMT transfers the methyl group from S-adenosyl-methionine to the hydroxyl group of catechol nucleus (such as dopamine, norepinephrine or catechol estrogen). Genetic variations found in COMT gene are associated with a broad spectrum of clinical phenotype including psychiatric disorders or estrogen related cancers. Several groups have performed studies on the relationship between schizophrenia and COMT. The most commonly studied polymorphism in COMT gene is rs4680 and it causes a valine methionine conversion at codon 158. The association studies on this polymorphism in different populations gave both positive and negative results. Schizoprenia is a complex disease caused by the interaction of environmental and genetic factors, while interpreting the genetic data, this fact and the possibility of the presence of different gene products should be taken into account. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(3.000): 217-226] |
| first_indexed | 2024-03-08T06:58:34Z |
| format | Article |
| id | doaj.art-2165f56ca9dd4df288d8a4a4454e446b |
| institution | Directory Open Access Journal |
| issn | 1309-0658 |
| language | English |
| last_indexed | 2024-03-08T06:58:34Z |
| publishDate | 2014-09-01 |
| publisher | Psikiyatride Güncel Yaklaşımlar |
| record_format | Article |
| series | Psikiyatride Güncel Yaklaşımlar |
| spelling | doaj.art-2165f56ca9dd4df288d8a4a4454e446b2024-02-03T06:18:18ZengPsikiyatride Güncel YaklaşımlarPsikiyatride Güncel Yaklaşımlar1309-06582014-09-016321722610.5455/cap.2013102512041945747The Role of Catechol-O-Methyltransferase (COMT) Gene in the Etiopathogenesis of SchizophreniaCeren Acar0sukru Kartalci1inonu Universitesi inonu UniversitesiGenetic factors in the risk of developing schizophrenia is of great importance. With the help of the advances in the field of genetics in recent years by using linkage analysis several genes have been identified that may be a risk factor in schizophrenia. Several association studies have been performed in many different populations on the candidate susceptibility genes that were defined in previous studies. However, these studies give controversial results in different countries with different populations, and there are problems in obtaining replicable results. In this review we aimed to focus on the genetic basis of schizophrenia and the relationship between schizophrenia and catechol-O-methyltransferase (COMT) gene. COMT encodes an enzyme molecule which has an important function in dopamine pathways. It has great importance in catecholamine metabolism and pharmacology and genetic mechanism of catechol metabolism variations and their clinical consequences. COMT transfers the methyl group from S-adenosyl-methionine to the hydroxyl group of catechol nucleus (such as dopamine, norepinephrine or catechol estrogen). Genetic variations found in COMT gene are associated with a broad spectrum of clinical phenotype including psychiatric disorders or estrogen related cancers. Several groups have performed studies on the relationship between schizophrenia and COMT. The most commonly studied polymorphism in COMT gene is rs4680 and it causes a valine methionine conversion at codon 158. The association studies on this polymorphism in different populations gave both positive and negative results. Schizoprenia is a complex disease caused by the interaction of environmental and genetic factors, while interpreting the genetic data, this fact and the possibility of the presence of different gene products should be taken into account. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(3.000): 217-226]http://www.cappsy.org/archives/vol6/no3/cap_06_03_02.pdfSchizophreniaCOMTpolymorphismcandidate gene |
| spellingShingle | Ceren Acar sukru Kartalci The Role of Catechol-O-Methyltransferase (COMT) Gene in the Etiopathogenesis of Schizophrenia Psikiyatride Güncel Yaklaşımlar Schizophrenia COMT polymorphism candidate gene |
| title | The Role of Catechol-O-Methyltransferase (COMT) Gene in the Etiopathogenesis of Schizophrenia |
| title_full | The Role of Catechol-O-Methyltransferase (COMT) Gene in the Etiopathogenesis of Schizophrenia |
| title_fullStr | The Role of Catechol-O-Methyltransferase (COMT) Gene in the Etiopathogenesis of Schizophrenia |
| title_full_unstemmed | The Role of Catechol-O-Methyltransferase (COMT) Gene in the Etiopathogenesis of Schizophrenia |
| title_short | The Role of Catechol-O-Methyltransferase (COMT) Gene in the Etiopathogenesis of Schizophrenia |
| title_sort | role of catechol o methyltransferase comt gene in the etiopathogenesis of schizophrenia |
| topic | Schizophrenia COMT polymorphism candidate gene |
| url | http://www.cappsy.org/archives/vol6/no3/cap_06_03_02.pdf |
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