Angiopoietin-like proteins: a comprehensive look
Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date eight ANGPTLs have been discovered, named ANGPLT1 to ANGPLT8. Emerging evidence implied a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological proc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00004/full |
| _version_ | 1818290016053362688 |
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| author | Gaetano eSantulli |
| author_facet | Gaetano eSantulli |
| author_sort | Gaetano eSantulli |
| collection | DOAJ |
| description | Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date eight ANGPTLs have been discovered, named ANGPLT1 to ANGPLT8. Emerging evidence implied a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPLT. |
| first_indexed | 2024-12-13T02:21:28Z |
| format | Article |
| id | doaj.art-216832b40d8947979b82d2410c087245 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T02:21:28Z |
| publishDate | 2014-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-216832b40d8947979b82d2410c0872452022-12-22T00:02:46ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922014-01-01510.3389/fendo.2014.0000478354Angiopoietin-like proteins: a comprehensive lookGaetano eSantulli0ColumbiaAngiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date eight ANGPTLs have been discovered, named ANGPLT1 to ANGPLT8. Emerging evidence implied a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes. Most of ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis and cancer. This report represents a systematic and updated appraisal of this class of proteins, focusing on the main features of each ANGPLT.http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00004/fullHematopoietic Stem CellsInflammationInsulinMetabolismCancerreview |
| spellingShingle | Gaetano eSantulli Angiopoietin-like proteins: a comprehensive look Frontiers in Endocrinology Hematopoietic Stem Cells Inflammation Insulin Metabolism Cancer review |
| title | Angiopoietin-like proteins: a comprehensive look |
| title_full | Angiopoietin-like proteins: a comprehensive look |
| title_fullStr | Angiopoietin-like proteins: a comprehensive look |
| title_full_unstemmed | Angiopoietin-like proteins: a comprehensive look |
| title_short | Angiopoietin-like proteins: a comprehensive look |
| title_sort | angiopoietin like proteins a comprehensive look |
| topic | Hematopoietic Stem Cells Inflammation Insulin Metabolism Cancer review |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00004/full |
| work_keys_str_mv | AT gaetanoesantulli angiopoietinlikeproteinsacomprehensivelook |