Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study
Abstract Background The burden of post-coronavirus disease (COVID)-19 symptoms has been increasing and is of great concern in patients with pre-existing chronic medical conditions.This study aimed to delineate the post-COVID-19 neuropsychiatric symptoms among migraine patients compared to the non-mi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-022-01468-y |
| _version_ | 1811215757917290496 |
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| author | Rehab Magdy Alaa Elmazny Shaimaa H. Soliman Eman H. Elsebaie Sara H. Ali Ali M. Abdel Fattah Mahmoud Hassan Ahmed Yassien Noha A. Mahfouz Radwa M. Elsayed Wael Fathy Hoda M. Abdel-Hamid Jehan Mohamed Mona Hussein |
| author_facet | Rehab Magdy Alaa Elmazny Shaimaa H. Soliman Eman H. Elsebaie Sara H. Ali Ali M. Abdel Fattah Mahmoud Hassan Ahmed Yassien Noha A. Mahfouz Radwa M. Elsayed Wael Fathy Hoda M. Abdel-Hamid Jehan Mohamed Mona Hussein |
| author_sort | Rehab Magdy |
| collection | DOAJ |
| description | Abstract Background The burden of post-coronavirus disease (COVID)-19 symptoms has been increasing and is of great concern in patients with pre-existing chronic medical conditions.This study aimed to delineate the post-COVID-19 neuropsychiatric symptoms among migraine patients compared to the non-migraine control group. Methods Two groups, each of 204 COVID-19 survivors, were enrolled in the study after 3 months of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, one group fulfilling the episodic migraine criteria and the other serving as a matching control group. Subjects were evaluated through an in-person interview for post-COVID-19 neuropsychiatric symptoms, including detailed headache patterns and severity, using the visual analogue scale. Results The Frequency of headache during the acute phase of COVID-19 was more frequent in migraine patients (OR = 1.60, 95%CI = 1.04–2.45, P-value = 0.031). The reported significant post-COVID-19 neuropsychiatric symptoms in migraine patients compared to controls were fatigue (OR = 1.662, 95%CI = 1.064–2.596, P-value = 0.025), anosmia/hyposmia (OR = 2.06, 95%CI = 1.164- 3.645, P-value = 0.012), cacosmia (OR = 2.663, 95%CI = 1.145–6.195, P-value = 0.019), depression (OR = 2.259, 95%CI = 1.284- 3.975, P-value = 0.004), anxiety (OR = 3.267, 95%CI = 1.747- 6.108, P-value ≤ 0.001), insomnia (OR = 2.203, 95%CI = 1.298- 3.739, P-value = 0.003), and headache (OR = 3.148, 95%CI = 1.616–6.136, P-value = ≤ 0.001).While there was no statistically significant difference between migraine patients and controls regarding the post-COVID-19 functional status score (P-value = 0.102). The pattern of post-COVID-19 headache was reported as chronic headache transformation in 17.6% of the migraine group, with the median intensity rate being 5.5 and IQR (3–7). In the control group, 14% experienced chronic headache attributed to systemic viral infection with a median intensity rate of 2 and IQR (2–5), while 12% experienced a new daily persistent headache with a median intensity of 5 and IQR (1–6). Conclusion The study highlighted the importance of follow-up migraine patients upon recovery from COVID-19 infection, being more vulnerable to post-COVID-19 symptoms. |
| first_indexed | 2024-04-12T06:27:48Z |
| format | Article |
| id | doaj.art-2168cc8ce1a240a680eb9f5a2da8b2cb |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-04-12T06:27:48Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-2168cc8ce1a240a680eb9f5a2da8b2cb2022-12-22T03:44:06ZengBMCThe Journal of Headache and Pain1129-23691129-23772022-08-0123111010.1186/s10194-022-01468-yPost-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control studyRehab Magdy0Alaa Elmazny1Shaimaa H. Soliman2Eman H. Elsebaie3Sara H. Ali4Ali M. Abdel Fattah5Mahmoud Hassan6Ahmed Yassien7Noha A. Mahfouz8Radwa M. Elsayed9Wael Fathy10Hoda M. Abdel-Hamid11Jehan Mohamed12Mona Hussein13Neurology Department, Faculty of Medicine, Cairo UniversityNeurology Department, Faculty of Medicine, Cairo UniversityNeurology Department, Faculty of Medicine, Cairo UniversityDepartment of Public Health and Community Medicine, Faculty of Medicine, Cairo UniversityDepartment of Otolaryngology, Faculty of Medicine, Beni-Suef UniversityDepartment of Gastroenterology, Hepatology, and Endemic Medicine, Faculty of Medicine, Beni-Suef UniversityDepartment of Internal Medicine, Faculty of Medicine, Beni-Suef UniversityDepartment of Critical Care Medicine, Beni-Suef UniversityDepartment of Psychiatry Faculty of Medicine, Cairo UniversityDepartment of Family Medicine, Faculty of Medicine, Cairo UniversityDepartment of Anaesthesia, Surgical ICU and Pain Management, Beni-Suef UniversityDepartment of Chest Diseases, Faculty of Medicine, Cairo UniversityDepartment of Anaesthesia, Surgical ICU and Pain Management, Beni-Suef UniversityNeurology department, Beni-Suef UniversityAbstract Background The burden of post-coronavirus disease (COVID)-19 symptoms has been increasing and is of great concern in patients with pre-existing chronic medical conditions.This study aimed to delineate the post-COVID-19 neuropsychiatric symptoms among migraine patients compared to the non-migraine control group. Methods Two groups, each of 204 COVID-19 survivors, were enrolled in the study after 3 months of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, one group fulfilling the episodic migraine criteria and the other serving as a matching control group. Subjects were evaluated through an in-person interview for post-COVID-19 neuropsychiatric symptoms, including detailed headache patterns and severity, using the visual analogue scale. Results The Frequency of headache during the acute phase of COVID-19 was more frequent in migraine patients (OR = 1.60, 95%CI = 1.04–2.45, P-value = 0.031). The reported significant post-COVID-19 neuropsychiatric symptoms in migraine patients compared to controls were fatigue (OR = 1.662, 95%CI = 1.064–2.596, P-value = 0.025), anosmia/hyposmia (OR = 2.06, 95%CI = 1.164- 3.645, P-value = 0.012), cacosmia (OR = 2.663, 95%CI = 1.145–6.195, P-value = 0.019), depression (OR = 2.259, 95%CI = 1.284- 3.975, P-value = 0.004), anxiety (OR = 3.267, 95%CI = 1.747- 6.108, P-value ≤ 0.001), insomnia (OR = 2.203, 95%CI = 1.298- 3.739, P-value = 0.003), and headache (OR = 3.148, 95%CI = 1.616–6.136, P-value = ≤ 0.001).While there was no statistically significant difference between migraine patients and controls regarding the post-COVID-19 functional status score (P-value = 0.102). The pattern of post-COVID-19 headache was reported as chronic headache transformation in 17.6% of the migraine group, with the median intensity rate being 5.5 and IQR (3–7). In the control group, 14% experienced chronic headache attributed to systemic viral infection with a median intensity rate of 2 and IQR (2–5), while 12% experienced a new daily persistent headache with a median intensity of 5 and IQR (1–6). Conclusion The study highlighted the importance of follow-up migraine patients upon recovery from COVID-19 infection, being more vulnerable to post-COVID-19 symptoms.https://doi.org/10.1186/s10194-022-01468-ySARS-CoV-2MigraineLong COVID-19Neuropsychiatric symptomsHeadache |
| spellingShingle | Rehab Magdy Alaa Elmazny Shaimaa H. Soliman Eman H. Elsebaie Sara H. Ali Ali M. Abdel Fattah Mahmoud Hassan Ahmed Yassien Noha A. Mahfouz Radwa M. Elsayed Wael Fathy Hoda M. Abdel-Hamid Jehan Mohamed Mona Hussein Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study The Journal of Headache and Pain SARS-CoV-2 Migraine Long COVID-19 Neuropsychiatric symptoms Headache |
| title | Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study |
| title_full | Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study |
| title_fullStr | Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study |
| title_full_unstemmed | Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study |
| title_short | Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case–control study |
| title_sort | post covid 19 neuropsychiatric manifestations among covid 19 survivors suffering from migraine a case control study |
| topic | SARS-CoV-2 Migraine Long COVID-19 Neuropsychiatric symptoms Headache |
| url | https://doi.org/10.1186/s10194-022-01468-y |
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