Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of ‘cancer stem cells (CSCs)’ in PDAC and molecular markers for them, stem cell dynamics in vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk...

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Bibliographic Details
Main Authors: Takahisa Maruno, Akihisa Fukuda, Norihiro Goto, Motoyuki Tsuda, Kozo Ikuta, Yukiko Hiramatsu, Satoshi Ogawa, Yuki Nakanishi, Yuichi Yamaga, Takuto Yoshioka, Kyoichi Takaori, Shinji Uemoto, Dieter Saur, Tsutomu Chiba, Hiroshi Seno
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
pancreatic adenocarcinoma
genetic lineage tracing
live imaging
cancer stem cells
Online Access:https://elifesciences.org/articles/55117

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