USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion
Abstract Liver ischemia/reperfusion (I/R) injury is a major clinical concern of liver transplantation, which accounts for organ rejection and liver dysfunction. The adaptor protein p66Shc acts as a crucial redox enzyme and is implicated in liver I/R. Elevated p66Shc expression is associated with hep...
Main Authors: | Xinyao Tian, Yan Zhao, Zhe Yang, Qianrang Lu, Lin Zhou, Shusen Zheng |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2022-09-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-022-05277-8 |
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