Characterization of 405B8H3(D‐E), a newly engineered high affinity chimeric LAG‐3 antibody with potent antitumor activity

Characterization of 405B8H3(D‐E), a newly engineered high affinity chimeric LAG‐3 antibody with potent antitumor activity

Lymphocyte activation gene‐3 (LAG‐3) is a type I transmembrane protein with structural similarities to CD4. Overexpression of LAG‐3 enables cancer cells to escape immune surveillance, while its blockade reinvigorates exhausted T cells and strengthens anti‐infection immunity. Blockade of LAG‐3 may ha...

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Bibliographic Details
Main Authors: Xiaoxuan Lan, Teddy Tat Chi Yang, Yinghui Wang, Baoyuan Qu, Shaofeng Rong, Ningning Song
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:FEBS Open Bio
Subjects:
405B8H3(D‐E)
antibody
cancer
HEK293
immunotherapy
LAG‐3
Online Access:https://doi.org/10.1002/2211-5463.13648

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