Amino acid metabolism in tumor biology and therapy
Abstract Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor immunity by acting as nutrients, signaling molecules, and could also regulate gene transcription and epigenetic modification...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-01-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-024-06435-w |
| _version_ | 1797355412465385472 |
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| author | Jie Chen Likun Cui Shaoteng Lu Sheng Xu |
| author_facet | Jie Chen Likun Cui Shaoteng Lu Sheng Xu |
| author_sort | Jie Chen |
| collection | DOAJ |
| description | Abstract Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor immunity by acting as nutrients, signaling molecules, and could also regulate gene transcription and epigenetic modification. Therefore, targeting amino acid metabolism will provide new ideas for tumor treatment and become an important therapeutic approach after surgery, radiotherapy, and chemotherapy. In this review, we systematically summarize the recent progress of amino acid metabolism in malignancy and their interaction with signal pathways as well as their effect on tumor microenvironment and epigenetic modification. Collectively, we also highlight the potential therapeutic application and future expectation. |
| first_indexed | 2024-03-08T14:11:53Z |
| format | Article |
| id | doaj.art-216e2bc1431442c49029794d34cc6040 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-03-08T14:11:53Z |
| publishDate | 2024-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-216e2bc1431442c49029794d34cc60402024-01-14T12:38:34ZengNature Publishing GroupCell Death and Disease2041-48892024-01-0115111810.1038/s41419-024-06435-wAmino acid metabolism in tumor biology and therapyJie Chen0Likun Cui1Shaoteng Lu2Sheng Xu3National Key Lab of Immunity and Inflammation and Institute of Immunology, Naval Medical University/Second Military Medical UniversityNational Key Lab of Immunity and Inflammation and Institute of Immunology, Naval Medical University/Second Military Medical UniversityNational Key Lab of Immunity and Inflammation and Institute of Immunology, Naval Medical University/Second Military Medical UniversityNational Key Lab of Immunity and Inflammation and Institute of Immunology, Naval Medical University/Second Military Medical UniversityAbstract Amino acid metabolism plays important roles in tumor biology and tumor therapy. Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor immunity by acting as nutrients, signaling molecules, and could also regulate gene transcription and epigenetic modification. Therefore, targeting amino acid metabolism will provide new ideas for tumor treatment and become an important therapeutic approach after surgery, radiotherapy, and chemotherapy. In this review, we systematically summarize the recent progress of amino acid metabolism in malignancy and their interaction with signal pathways as well as their effect on tumor microenvironment and epigenetic modification. Collectively, we also highlight the potential therapeutic application and future expectation.https://doi.org/10.1038/s41419-024-06435-w |
| spellingShingle | Jie Chen Likun Cui Shaoteng Lu Sheng Xu Amino acid metabolism in tumor biology and therapy Cell Death and Disease |
| title | Amino acid metabolism in tumor biology and therapy |
| title_full | Amino acid metabolism in tumor biology and therapy |
| title_fullStr | Amino acid metabolism in tumor biology and therapy |
| title_full_unstemmed | Amino acid metabolism in tumor biology and therapy |
| title_short | Amino acid metabolism in tumor biology and therapy |
| title_sort | amino acid metabolism in tumor biology and therapy |
| url | https://doi.org/10.1038/s41419-024-06435-w |
| work_keys_str_mv | AT jiechen aminoacidmetabolismintumorbiologyandtherapy AT likuncui aminoacidmetabolismintumorbiologyandtherapy AT shaotenglu aminoacidmetabolismintumorbiologyandtherapy AT shengxu aminoacidmetabolismintumorbiologyandtherapy |