Cepharanthine as a Potential Novel Tumor-Regional Therapy in Treating Cutaneous Melanoma: Altering the Expression of Cathepsin B, Tumor Suppressor Genes and Autophagy-Related Proteins

Cepharanthine as a Potential Novel Tumor-Regional Therapy in Treating Cutaneous Melanoma: Altering the Expression of Cathepsin B, Tumor Suppressor Genes and Autophagy-Related Proteins

The incidence of primary cutaneous melanoma continues to increase annually and is one of the most aggressive malignancies in humans and need to develop more novel non-surgical therapies. Autophagy and cathepsin B targeted therapy was reported to improve melanoma treatment. Cepharanthine (CEP), a nat...

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Bibliographic Details
Main Authors: Yufang Liu, Yang Xie, Yao Lin, Qingfang Xu, Yunfen Huang, Mengran Peng, Wei Lai, Yue Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
melanoma
cepharanthine
skin
cathepsin B
autophagy
treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.601969/full

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