Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2
Influenza is a respiratory virus that alone or in combination with secondary bacterial pathogens can contribute to the development of acute pneumonia in persons >65 years of age. Host innate immune antiviral signaling early in response to influenza is essential to inhibit early viral replication...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/22/12097 |
| _version_ | 1797510043810136064 |
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| author | Rebecca Harris Jianjun Yang Kassandra Pagan Soo Jung Cho Heather Stout-Delgado |
| author_facet | Rebecca Harris Jianjun Yang Kassandra Pagan Soo Jung Cho Heather Stout-Delgado |
| author_sort | Rebecca Harris |
| collection | DOAJ |
| description | Influenza is a respiratory virus that alone or in combination with secondary bacterial pathogens can contribute to the development of acute pneumonia in persons >65 years of age. Host innate immune antiviral signaling early in response to influenza is essential to inhibit early viral replication and guide the initiation of adaptive immune responses. Using young adult (3 months) and aged adult mice infected with mouse adapted H1N1 or H3N2, the results of our study illustrate dysregulated and/or diminished activation of key signaling pathways in aged lung contribute to increased lung inflammation and morbidity. Specifically, within the first seven days of infection, there were significant changes in genes associated with TLR and RIG-I signaling detected in aged murine lung in response to H1N1 or H3N2. Taken together, the results of our study expand our current understanding of age-associated changes in antiviral signaling in the lung. |
| first_indexed | 2024-03-10T05:26:19Z |
| format | Article |
| id | doaj.art-21729b9ad8a840149e3565fddd7b7402 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:26:19Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-21729b9ad8a840149e3565fddd7b74022023-11-22T23:37:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221209710.3390/ijms222212097Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2Rebecca Harris0Jianjun Yang1Kassandra Pagan2Soo Jung Cho3Heather Stout-Delgado4Weill Cornell Medicine, Division of Pulmonary and Critical Care, New York, NY 10021, USAWeill Cornell Medicine, Division of Pulmonary and Critical Care, New York, NY 10021, USAWeill Cornell Medicine, Division of Pulmonary and Critical Care, New York, NY 10021, USAWeill Cornell Medicine, Division of Pulmonary and Critical Care, New York, NY 10021, USAWeill Cornell Medicine, Division of Pulmonary and Critical Care, New York, NY 10021, USAInfluenza is a respiratory virus that alone or in combination with secondary bacterial pathogens can contribute to the development of acute pneumonia in persons >65 years of age. Host innate immune antiviral signaling early in response to influenza is essential to inhibit early viral replication and guide the initiation of adaptive immune responses. Using young adult (3 months) and aged adult mice infected with mouse adapted H1N1 or H3N2, the results of our study illustrate dysregulated and/or diminished activation of key signaling pathways in aged lung contribute to increased lung inflammation and morbidity. Specifically, within the first seven days of infection, there were significant changes in genes associated with TLR and RIG-I signaling detected in aged murine lung in response to H1N1 or H3N2. Taken together, the results of our study expand our current understanding of age-associated changes in antiviral signaling in the lung.https://www.mdpi.com/1422-0067/22/22/12097antiviralH3N2H1N1influenzaaginglung |
| spellingShingle | Rebecca Harris Jianjun Yang Kassandra Pagan Soo Jung Cho Heather Stout-Delgado Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2 International Journal of Molecular Sciences antiviral H3N2 H1N1 influenza aging lung |
| title | Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2 |
| title_full | Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2 |
| title_fullStr | Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2 |
| title_full_unstemmed | Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2 |
| title_short | Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2 |
| title_sort | antiviral gene expression in young and aged murine lung during h1n1 and h3n2 |
| topic | antiviral H3N2 H1N1 influenza aging lung |
| url | https://www.mdpi.com/1422-0067/22/22/12097 |
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