Hydroxylation of the Acetyltransferase NAA10 Trp38 Is Not an Enzyme-Switch in Human Cells

Hydroxylation of the Acetyltransferase NAA10 Trp38 Is Not an Enzyme-Switch in Human Cells

NAA10 is a major <i>N</i>-terminal acetyltransferase (NAT) that catalyzes the cotranslational <i>N</i>-terminal (Nt-) acetylation of 40% of the human proteome. Several reports of lysine acetyltransferase (KAT) activity by NAA10 exist, but others have not been able to find any...

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Bibliographic Details
Main Authors: Rasmus Ree, Karoline Krogstad, Nina McTiernan, Magnus E. Jakobsson, Thomas Arnesen
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
protein hydroxylation
protein acetylation
proteomics
POST-translational modification
<i>N</i>-terminal acetyltransferase
NAA10
Online Access:https://www.mdpi.com/1422-0067/22/21/11805

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