Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population.
We investigated the possible association between genetic variants in the Patatin like phospholipase-3 (PNPLA3) gene and nonalcoholic fatty liver disease (NAFLD) in a Han Chinese population. We evaluated twelve tagging single-nucleotide polymorphisms (tSNPs) of the PNPLA3 gene in a frequency matched...
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3511464?pdf=render |
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| author | Xian-E Peng Yun-Li Wu Shao-Wei Lin Qing-Qing Lu Zhi-Jian Hu Xu Lin |
| author_facet | Xian-E Peng Yun-Li Wu Shao-Wei Lin Qing-Qing Lu Zhi-Jian Hu Xu Lin |
| author_sort | Xian-E Peng |
| collection | DOAJ |
| description | We investigated the possible association between genetic variants in the Patatin like phospholipase-3 (PNPLA3) gene and nonalcoholic fatty liver disease (NAFLD) in a Han Chinese population. We evaluated twelve tagging single-nucleotide polymorphisms (tSNPs) of the PNPLA3 gene in a frequency matched case-control study from Fuzhou city of China (553 cases, 553 controls). In the multivariate logistic regression analysis, the rs738409 GG or GC, and rs139051 TT genotypes were found to be associated with increased risk of NAFLD, and a significant trend of increased risk with increasing numbers of risk genotype was observed in the cumulative effect analysis of these single nucleotide polymorphisms. Furthermore, haplotype association analysis showed that, compared with the most common haplotype, the CAAGAATGCGTG and CGAAGGTGTCCG haplotypes conferred a statistically significant increased risk for NAFLD, while the CGGGAACCCGCG haplotype decreased the risk of NAFLD. Moreover, rs738409 C>G appeared to have a multiplicative joint effect with tea drinking (P<0.005) and an additive joint effect with obesity (Interaction contrast ratio (ICR) = 2.31, 95% CI: 0.7-8.86), hypertriglyceridemia (ICR = 3.07, 95% CI: 0.98-5.09) or hypertension (ICR = 1.74, 95% CI: 0.52-3.12). Our data suggests that PNPLA3 genetic polymorphisms might influence the susceptibility to NAFLD development independently or jointly in Han Chinese. |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T20:14:38Z |
| publishDate | 2012-01-01 |
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| series | PLoS ONE |
| spelling | doaj.art-2176c7290bd340d9867d4d2b32d1b7b62022-12-22T00:52:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e5025610.1371/journal.pone.0050256Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population.Xian-E PengYun-Li WuShao-Wei LinQing-Qing LuZhi-Jian HuXu LinWe investigated the possible association between genetic variants in the Patatin like phospholipase-3 (PNPLA3) gene and nonalcoholic fatty liver disease (NAFLD) in a Han Chinese population. We evaluated twelve tagging single-nucleotide polymorphisms (tSNPs) of the PNPLA3 gene in a frequency matched case-control study from Fuzhou city of China (553 cases, 553 controls). In the multivariate logistic regression analysis, the rs738409 GG or GC, and rs139051 TT genotypes were found to be associated with increased risk of NAFLD, and a significant trend of increased risk with increasing numbers of risk genotype was observed in the cumulative effect analysis of these single nucleotide polymorphisms. Furthermore, haplotype association analysis showed that, compared with the most common haplotype, the CAAGAATGCGTG and CGAAGGTGTCCG haplotypes conferred a statistically significant increased risk for NAFLD, while the CGGGAACCCGCG haplotype decreased the risk of NAFLD. Moreover, rs738409 C>G appeared to have a multiplicative joint effect with tea drinking (P<0.005) and an additive joint effect with obesity (Interaction contrast ratio (ICR) = 2.31, 95% CI: 0.7-8.86), hypertriglyceridemia (ICR = 3.07, 95% CI: 0.98-5.09) or hypertension (ICR = 1.74, 95% CI: 0.52-3.12). Our data suggests that PNPLA3 genetic polymorphisms might influence the susceptibility to NAFLD development independently or jointly in Han Chinese.http://europepmc.org/articles/PMC3511464?pdf=render |
| spellingShingle | Xian-E Peng Yun-Li Wu Shao-Wei Lin Qing-Qing Lu Zhi-Jian Hu Xu Lin Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population. PLoS ONE |
| title | Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population. |
| title_full | Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population. |
| title_fullStr | Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population. |
| title_full_unstemmed | Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population. |
| title_short | Genetic variants in PNPLA3 and risk of non-alcoholic fatty liver disease in a Han Chinese population. |
| title_sort | genetic variants in pnpla3 and risk of non alcoholic fatty liver disease in a han chinese population |
| url | http://europepmc.org/articles/PMC3511464?pdf=render |
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