In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has put scientist and pharmaceutical companies worldwide on the spot to develop novel treatment options and reliable vaccination for billions of people. To combat its associated disease COVID-19 and potentially ne...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/5/792 |
| _version_ | 1797535826742083584 |
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| author | Natalie Heinen Mara Klöhn Eike Steinmann Stephanie Pfaender |
| author_facet | Natalie Heinen Mara Klöhn Eike Steinmann Stephanie Pfaender |
| author_sort | Natalie Heinen |
| collection | DOAJ |
| description | SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has put scientist and pharmaceutical companies worldwide on the spot to develop novel treatment options and reliable vaccination for billions of people. To combat its associated disease COVID-19 and potentially newly emerging coronaviruses, numerous pre-clinical cell culture techniques have progressively been used, which allow the study of SARS-CoV-2 pathogenesis, basic replication mechanisms, and drug efficiency in the most authentic context. Hence, this review was designed to summarize and discuss currently used in vitro and ex vivo cell culture systems and will illustrate how these systems will help us to face the challenges imposed by the current SARS-CoV-2 pandemic. |
| first_indexed | 2024-03-10T11:50:50Z |
| format | Article |
| id | doaj.art-2179287b74544739b483d3afa0f30f5a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T11:50:50Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-2179287b74544739b483d3afa0f30f5a2023-11-21T17:40:31ZengMDPI AGViruses1999-49152021-04-0113579210.3390/v13050792In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and DiseaseNatalie Heinen0Mara Klöhn1Eike Steinmann2Stephanie Pfaender3Department of Molecular and Medical Virology, Ruhr-University Bochum, 44801 Bochum, GermanyDepartment of Molecular and Medical Virology, Ruhr-University Bochum, 44801 Bochum, GermanyDepartment of Molecular and Medical Virology, Ruhr-University Bochum, 44801 Bochum, GermanyDepartment of Molecular and Medical Virology, Ruhr-University Bochum, 44801 Bochum, GermanySARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has put scientist and pharmaceutical companies worldwide on the spot to develop novel treatment options and reliable vaccination for billions of people. To combat its associated disease COVID-19 and potentially newly emerging coronaviruses, numerous pre-clinical cell culture techniques have progressively been used, which allow the study of SARS-CoV-2 pathogenesis, basic replication mechanisms, and drug efficiency in the most authentic context. Hence, this review was designed to summarize and discuss currently used in vitro and ex vivo cell culture systems and will illustrate how these systems will help us to face the challenges imposed by the current SARS-CoV-2 pandemic.https://www.mdpi.com/1999-4915/13/5/792SARS-CoV-2in vitro lung modelcell culturehuman airway epithelial cell culturehuman lung organoidslung-on-a-chip |
| spellingShingle | Natalie Heinen Mara Klöhn Eike Steinmann Stephanie Pfaender In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease Viruses SARS-CoV-2 in vitro lung model cell culture human airway epithelial cell culture human lung organoids lung-on-a-chip |
| title | In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease |
| title_full | In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease |
| title_fullStr | In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease |
| title_full_unstemmed | In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease |
| title_short | In Vitro Lung Models and Their Application to Study SARS-CoV-2 Pathogenesis and Disease |
| title_sort | in vitro lung models and their application to study sars cov 2 pathogenesis and disease |
| topic | SARS-CoV-2 in vitro lung model cell culture human airway epithelial cell culture human lung organoids lung-on-a-chip |
| url | https://www.mdpi.com/1999-4915/13/5/792 |
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