DNA damage and repair in the hematopoietic system

DNA damage and repair in the hematopoietic system

Although hematopoietic stem cells (HSCs) in the bone marrow are in a state of quiescence, they harbor the self-renewal capacity and the pluripotency to differentiate into mature blood cells when needed, which is key to maintain hematopoietic homeostasis. Importantly, HSCs are characterized by their...

Full description

Bibliographic Details
Main Authors: Li Niu, Chen Hongzhu, Wang Jian
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
c-NHEJ
DNA inter-strand crosslink
FA/BRCA pathway
hematopoietic stem cell
oxidative damage
replication stress
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022053

Similar Items

Similar Items