Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus <i>Curvularia</i> sp.
Chemical investigation of the mycelia of the pathogenic fungus <i>Curvularia</i> sp. which was isolated from a leaf of <i>Dactyloctenium aegyptium</i> (crowfoot grass), resulted in the isolation of a new compound, curvulariahawadride (5), along with five known compounds (1–4,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/6/408 |
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| author | Virayu Suthiphasilp Achara Raksat Tharakorn Maneerat Sarinya Hadsadee Siriporn Jungsuttiwong Stephen G. Pyne Putarak Chomnunti Wuttichai Jaidee Rawiwan Charoensup Surat Laphookhieo |
| author_facet | Virayu Suthiphasilp Achara Raksat Tharakorn Maneerat Sarinya Hadsadee Siriporn Jungsuttiwong Stephen G. Pyne Putarak Chomnunti Wuttichai Jaidee Rawiwan Charoensup Surat Laphookhieo |
| author_sort | Virayu Suthiphasilp |
| collection | DOAJ |
| description | Chemical investigation of the mycelia of the pathogenic fungus <i>Curvularia</i> sp. which was isolated from a leaf of <i>Dactyloctenium aegyptium</i> (crowfoot grass), resulted in the isolation of a new compound, curvulariahawadride (5), along with five known compounds (1–4, and 6). Their structures were determined on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS. The absolute configuration of 5 was established from experimental and calculated electronic circular dichroism (ECD). Compounds 1, 3, and 5 showed nitric oxide (NO) production inhibitory activity with IC<sub>50</sub> values of 53.7, 32.8, and 12.8 µM, respectively. Compounds 2 and 4 showed significant cytotoxicity against lung cancer A549, colorectal cancer SW480, and leukemic K562 cells with an IC<sub>50</sub> ranging value of 11.73 to 17.59 µM. |
| first_indexed | 2024-03-10T11:08:04Z |
| format | Article |
| id | doaj.art-217aab145b9543d79f67e3d6b191e66b |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T11:08:04Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-217aab145b9543d79f67e3d6b191e66b2023-11-21T20:57:23ZengMDPI AGJournal of Fungi2309-608X2021-05-017640810.3390/jof7060408Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus <i>Curvularia</i> sp.Virayu Suthiphasilp0Achara Raksat1Tharakorn Maneerat2Sarinya Hadsadee3Siriporn Jungsuttiwong4Stephen G. Pyne5Putarak Chomnunti6Wuttichai Jaidee7Rawiwan Charoensup8Surat Laphookhieo9Center of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandCenter of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandCenter of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandCenter for Organic Electronic and Alternative Energy, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, ThailandCenter for Organic Electronic and Alternative Energy, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, ThailandSchool of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, AustraliaCenter of Excellence in Fungal Research, School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandMedicinal Plants Innovation Center of Mae Fah Luang University, Chiang Rai 57100, ThailandMedicinal Plants Innovation Center of Mae Fah Luang University, Chiang Rai 57100, ThailandCenter of Chemical Innovation for Sustainability, School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandChemical investigation of the mycelia of the pathogenic fungus <i>Curvularia</i> sp. which was isolated from a leaf of <i>Dactyloctenium aegyptium</i> (crowfoot grass), resulted in the isolation of a new compound, curvulariahawadride (5), along with five known compounds (1–4, and 6). Their structures were determined on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS. The absolute configuration of 5 was established from experimental and calculated electronic circular dichroism (ECD). Compounds 1, 3, and 5 showed nitric oxide (NO) production inhibitory activity with IC<sub>50</sub> values of 53.7, 32.8, and 12.8 µM, respectively. Compounds 2 and 4 showed significant cytotoxicity against lung cancer A549, colorectal cancer SW480, and leukemic K562 cells with an IC<sub>50</sub> ranging value of 11.73 to 17.59 µM.https://www.mdpi.com/2309-608X/7/6/408<i>Curvularia</i> sp.<i>Dactyloctenium aegyptium</i>curvulariahawadridecytotoxicitynitric oxide production inhibitory activity |
| spellingShingle | Virayu Suthiphasilp Achara Raksat Tharakorn Maneerat Sarinya Hadsadee Siriporn Jungsuttiwong Stephen G. Pyne Putarak Chomnunti Wuttichai Jaidee Rawiwan Charoensup Surat Laphookhieo Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus <i>Curvularia</i> sp. Journal of Fungi <i>Curvularia</i> sp. <i>Dactyloctenium aegyptium</i> curvulariahawadride cytotoxicity nitric oxide production inhibitory activity |
| title | Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus <i>Curvularia</i> sp. |
| title_full | Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus <i>Curvularia</i> sp. |
| title_fullStr | Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus <i>Curvularia</i> sp. |
| title_full_unstemmed | Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus <i>Curvularia</i> sp. |
| title_short | Cytotoxicity and Nitric Oxide Production Inhibitory Activities of Compounds Isolated from the Plant Pathogenic Fungus <i>Curvularia</i> sp. |
| title_sort | cytotoxicity and nitric oxide production inhibitory activities of compounds isolated from the plant pathogenic fungus i curvularia i sp |
| topic | <i>Curvularia</i> sp. <i>Dactyloctenium aegyptium</i> curvulariahawadride cytotoxicity nitric oxide production inhibitory activity |
| url | https://www.mdpi.com/2309-608X/7/6/408 |
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