Single-Cell Profiling of Latently SIV-Infected CD4+ T Cells Directly Ex Vivo to Reveal Host Factors Supporting Reservoir Persistence

Single-Cell Profiling of Latently SIV-Infected CD4+ T Cells Directly Ex Vivo to Reveal Host Factors Supporting Reservoir Persistence

ABSTRACT HIV-1 cure strategies aiming to eliminate persistent infected cell reservoirs are hampered by a poor understanding of cells harboring viral DNA in vivo. We describe a novel method to identify, enumerate, and characterize in detail individual cells infected in vivo using a combination of sin...

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Bibliographic Details
Main Authors: Andrey Tokarev, Kawthar Machmach, Matthew Creegan, Dohoon Kim, Michael A. Eller, Diane L. Bolton
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
host-pathogen interactions
latent infection
reservoir
simian immunodeficiency virus
single-cell
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00604-22

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