The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing
Gut microbial composition codevelops with the host from birth and is influenced by several factors, including drug use, radiation, psychological stress, dietary changes and physical stress. Importantly, gut microbial dysbiosis has been clearly associated with several diseases, including cancer, rheu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/9/1869 |
| _version_ | 1827658507638276096 |
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| author | Ruqaiyyah Siddiqui Mohammad Ridwane Mungroo Ahmad M. Alharbi Hasan Alfahemi Naveed Ahmed Khan |
| author_facet | Ruqaiyyah Siddiqui Mohammad Ridwane Mungroo Ahmad M. Alharbi Hasan Alfahemi Naveed Ahmed Khan |
| author_sort | Ruqaiyyah Siddiqui |
| collection | DOAJ |
| description | Gut microbial composition codevelops with the host from birth and is influenced by several factors, including drug use, radiation, psychological stress, dietary changes and physical stress. Importantly, gut microbial dysbiosis has been clearly associated with several diseases, including cancer, rheumatoid arthritis and <i>Clostridium difficile</i>-associated diarrhoea, and is known to affect human health and performance. Herein, we discuss that a shift in the gut microbiota with age and reversal of age-related modulation of the gut microbiota could be a major contributor to the incidence of numerous age-related diseases or overall human performance. In addition, it is suggested that the gut microbiome of long-lived animals such as reptiles should be investigated for their unique properties and contribution to the potent defense system of these species could be extrapolated for the benefit of human health. A range of techniques can be used to modulate the gut microbiota to have higher abundance of “beneficial” microbes that have been linked with health and longevity. |
| first_indexed | 2024-03-09T23:04:40Z |
| format | Article |
| id | doaj.art-21821a21a8314d53881c64cf55c59289 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T23:04:40Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-21821a21a8314d53881c64cf55c592892023-11-23T17:54:38ZengMDPI AGMicroorganisms2076-26072022-09-01109186910.3390/microorganisms10091869The Use of Gut Microbial Modulation Strategies as Interventional Strategies for AgeingRuqaiyyah Siddiqui0Mohammad Ridwane Mungroo1Ahmad M. Alharbi2Hasan Alfahemi3Naveed Ahmed Khan4College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box 26666, United Arab EmiratesDepartment of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab EmiratesDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi ArabiaDepartment of Medical Microbiology, Faculty of Medicine, Al-Baha University, Al-Baha 65799, Saudi ArabiaDepartment of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab EmiratesGut microbial composition codevelops with the host from birth and is influenced by several factors, including drug use, radiation, psychological stress, dietary changes and physical stress. Importantly, gut microbial dysbiosis has been clearly associated with several diseases, including cancer, rheumatoid arthritis and <i>Clostridium difficile</i>-associated diarrhoea, and is known to affect human health and performance. Herein, we discuss that a shift in the gut microbiota with age and reversal of age-related modulation of the gut microbiota could be a major contributor to the incidence of numerous age-related diseases or overall human performance. In addition, it is suggested that the gut microbiome of long-lived animals such as reptiles should be investigated for their unique properties and contribution to the potent defense system of these species could be extrapolated for the benefit of human health. A range of techniques can be used to modulate the gut microbiota to have higher abundance of “beneficial” microbes that have been linked with health and longevity.https://www.mdpi.com/2076-2607/10/9/1869gut microbiotamicrobiota modulationmicrobiota developmentFMTfaecal microbiota transplantationprebiotics |
| spellingShingle | Ruqaiyyah Siddiqui Mohammad Ridwane Mungroo Ahmad M. Alharbi Hasan Alfahemi Naveed Ahmed Khan The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing Microorganisms gut microbiota microbiota modulation microbiota development FMT faecal microbiota transplantation prebiotics |
| title | The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing |
| title_full | The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing |
| title_fullStr | The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing |
| title_full_unstemmed | The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing |
| title_short | The Use of Gut Microbial Modulation Strategies as Interventional Strategies for Ageing |
| title_sort | use of gut microbial modulation strategies as interventional strategies for ageing |
| topic | gut microbiota microbiota modulation microbiota development FMT faecal microbiota transplantation prebiotics |
| url | https://www.mdpi.com/2076-2607/10/9/1869 |
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