Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex
Background: The ABO blood antigens may influence the levels of vWF: Ag and put individuals at risk of coagulopathies. This study assessed the plasma vWF: Ag and its relation with ABO blood antigens among healthy adults in northern Ghana. Methods: This cross-sectional study recruited 84 blood donors,...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Ital Publication
2022-06-01
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| Series: | SciMedicine Journal |
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| Online Access: | https://www.scimedjournal.org/index.php/SMJ/article/view/438 |
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| author | Samuel K. Appiah Charles Nkansah Kofi Mensah Felix Osei-Boakye Dorcas Serwaa Simon B. Bani Gabriel Abbam Samira Daud Mandeiya D. A. Yakubu Abraham B. Sagoe Charles A. Derigubah Yeduah Quansah Vincent Kawuribi |
| author_facet | Samuel K. Appiah Charles Nkansah Kofi Mensah Felix Osei-Boakye Dorcas Serwaa Simon B. Bani Gabriel Abbam Samira Daud Mandeiya D. A. Yakubu Abraham B. Sagoe Charles A. Derigubah Yeduah Quansah Vincent Kawuribi |
| author_sort | Samuel K. Appiah |
| collection | DOAJ |
| description | Background: The ABO blood antigens may influence the levels of vWF: Ag and put individuals at risk of coagulopathies. This study assessed the plasma vWF: Ag and its relation with ABO blood antigens among healthy adults in northern Ghana. Methods: This cross-sectional study recruited 84 blood donors, aged 18–50 years, at Tamale Teaching Hospital. Blood groups were determined using the standard tube method, and a complete blood count was measured with an automated haematology analyzer. Sandwich ELISA was used to assess plasma vWF: Ag levels. The data obtained were analyzed using SPSS version 22. Results: The frequencies of O, A, B, and AB blood groups were 34 (40.5%), 25 (29.8%), 20 (23.8%), and 5 (6.0%), respectively. vWF: Ag levels were higher among the non-O than group O individuals (p = 0.008). Plasma vWF: Ag levels were lower in group O compared to AB (p = 0.015) and A (p = 0.013) individuals. Males had higher vWF: Ag levels than females (p = 0.002). A moderately positive correlation was observed between age and vWF levels (r = 0.497, p<0.001). Blood group O participants had lower absolute neutrophil counts (p = 0.039), but higher RDW-SD (p = 0.045). Conclusion: The predominant blood group was O, followed by other groups in the order: O>A>B>AB. Plasma vWF: Ag levels were higher in non-group O compared with group O individuals. Males had higher vWF: Ag levels, and a positive correlation between age and vWF: Ag was observed. Again, blood group O participants had lower neutrophil counts, but higher RDW-SD. The relationship between ABO blood phenotypes and plasma vWF: Ag should be considered in clinical practice. The establishment of separate reference intervals of vWF: Ag for the various phenotypes of ABO is recommended. Also, the study recommends further multicenter studies to assess the link between ABO phenotypes and all the endothelial cell parameters.
Doi: 10.28991/SciMedJ-2022-04-02-02
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| first_indexed | 2024-03-13T09:58:21Z |
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| language | English |
| last_indexed | 2024-03-13T09:58:21Z |
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| spelling | doaj.art-218442ddde964f0d94c0acbc5055ee9e2023-05-23T11:11:37ZengItal PublicationSciMedicine Journal2704-98332022-06-0142637210.28991/SciMedJ-2022-04-02-02113Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and SexSamuel K. Appiah0Charles Nkansah1Kofi Mensah2Felix Osei-Boakye3Dorcas Serwaa4Simon B. Bani5Gabriel Abbam6Samira Daud7Mandeiya D. A. Yakubu8Abraham B. Sagoe9Charles A. Derigubah10Yeduah Quansah11Vincent Kawuribi121) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,Department of Medical Laboratory Technology, Faculty of Applied Science and Technology, Sunyani Technical University, Sunyani,Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne,Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, TamaleDepartment of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale,Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale,Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, TamaleDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, TamaleDepartment of Medical Laboratory Technology, School of Applied Science and Arts, Bolgatanga Technical University, Bolgatanga,Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, TamaleDepartment of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, TamaleBackground: The ABO blood antigens may influence the levels of vWF: Ag and put individuals at risk of coagulopathies. This study assessed the plasma vWF: Ag and its relation with ABO blood antigens among healthy adults in northern Ghana. Methods: This cross-sectional study recruited 84 blood donors, aged 18–50 years, at Tamale Teaching Hospital. Blood groups were determined using the standard tube method, and a complete blood count was measured with an automated haematology analyzer. Sandwich ELISA was used to assess plasma vWF: Ag levels. The data obtained were analyzed using SPSS version 22. Results: The frequencies of O, A, B, and AB blood groups were 34 (40.5%), 25 (29.8%), 20 (23.8%), and 5 (6.0%), respectively. vWF: Ag levels were higher among the non-O than group O individuals (p = 0.008). Plasma vWF: Ag levels were lower in group O compared to AB (p = 0.015) and A (p = 0.013) individuals. Males had higher vWF: Ag levels than females (p = 0.002). A moderately positive correlation was observed between age and vWF levels (r = 0.497, p<0.001). Blood group O participants had lower absolute neutrophil counts (p = 0.039), but higher RDW-SD (p = 0.045). Conclusion: The predominant blood group was O, followed by other groups in the order: O>A>B>AB. Plasma vWF: Ag levels were higher in non-group O compared with group O individuals. Males had higher vWF: Ag levels, and a positive correlation between age and vWF: Ag was observed. Again, blood group O participants had lower neutrophil counts, but higher RDW-SD. The relationship between ABO blood phenotypes and plasma vWF: Ag should be considered in clinical practice. The establishment of separate reference intervals of vWF: Ag for the various phenotypes of ABO is recommended. Also, the study recommends further multicenter studies to assess the link between ABO phenotypes and all the endothelial cell parameters. Doi: 10.28991/SciMedJ-2022-04-02-02 Full Text: PDFhttps://www.scimedjournal.org/index.php/SMJ/article/view/438blood cell indicesblood groupelisavwfag. |
| spellingShingle | Samuel K. Appiah Charles Nkansah Kofi Mensah Felix Osei-Boakye Dorcas Serwaa Simon B. Bani Gabriel Abbam Samira Daud Mandeiya D. A. Yakubu Abraham B. Sagoe Charles A. Derigubah Yeduah Quansah Vincent Kawuribi Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex SciMedicine Journal blood cell indices blood group elisa vwf ag. |
| title | Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex |
| title_full | Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex |
| title_fullStr | Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex |
| title_full_unstemmed | Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex |
| title_short | Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex |
| title_sort | plasma von willebrand factor antigen levels and its relation with abo blood group age and sex |
| topic | blood cell indices blood group elisa vwf ag. |
| url | https://www.scimedjournal.org/index.php/SMJ/article/view/438 |
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