Mid-old cells are a potential target for anti-aging interventions in the elderly
Abstract The biological process of aging is thought to result in part from accumulation of senescent cells in organs. However, the present study identified a subset of fibroblasts and smooth muscle cells which are the major constituents of organ stroma neither proliferative nor senescent in tissues...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-43491-w |
| _version_ | 1797452152605507584 |
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| author | Young Hwa Kim Young-Kyoung Lee Soon Sang Park So Hyun Park So Yeong Eom Young-Sam Lee Wonhee John Lee Juhee Jang Daeha Seo Hee Young Kang Jin Cheol Kim Su Bin Lim Gyesoon Yoon Hong Seok Kim Jang-Hee Kim Tae Jun Park |
| author_facet | Young Hwa Kim Young-Kyoung Lee Soon Sang Park So Hyun Park So Yeong Eom Young-Sam Lee Wonhee John Lee Juhee Jang Daeha Seo Hee Young Kang Jin Cheol Kim Su Bin Lim Gyesoon Yoon Hong Seok Kim Jang-Hee Kim Tae Jun Park |
| author_sort | Young Hwa Kim |
| collection | DOAJ |
| description | Abstract The biological process of aging is thought to result in part from accumulation of senescent cells in organs. However, the present study identified a subset of fibroblasts and smooth muscle cells which are the major constituents of organ stroma neither proliferative nor senescent in tissues of the elderly, which we termed “mid-old status” cells. Upregulation of pro-inflammatory genes (IL1B and SAA1) and downregulation of anti-inflammatory genes (SLIT2 and CXCL12) were detected in mid-old cells. In the stroma, SAA1 promotes development of the inflammatory microenvironment via upregulation of MMP9, which decreases the stability of epithelial cells present on the basement membrane, decreasing epithelial cell function. Remarkably, the microenvironmental change and the functional decline of mid-old cells could be reversed by a young cell-originated protein, SLIT2. Our data identify functional reversion of mid-old cells as a potential method to prevent or ameliorate aspects of aging-related tissue dysfunction. |
| first_indexed | 2024-03-09T15:03:42Z |
| format | Article |
| id | doaj.art-2185100074d749c98bfbd9b5e5a7c2b8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-09T15:03:42Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2185100074d749c98bfbd9b5e5a7c2b82023-11-26T13:44:12ZengNature PortfolioNature Communications2041-17232023-11-0114111610.1038/s41467-023-43491-wMid-old cells are a potential target for anti-aging interventions in the elderlyYoung Hwa Kim0Young-Kyoung Lee1Soon Sang Park2So Hyun Park3So Yeong Eom4Young-Sam Lee5Wonhee John Lee6Juhee Jang7Daeha Seo8Hee Young Kang9Jin Cheol Kim10Su Bin Lim11Gyesoon Yoon12Hong Seok Kim13Jang-Hee Kim14Tae Jun Park15Inflamm-Aging Translational Research Center, Ajou University Medical CenterInflamm-Aging Translational Research Center, Ajou University Medical CenterInflamm-Aging Translational Research Center, Ajou University Medical CenterDepartment of Pathology, Ajou University School of MedicineInflamm-Aging Translational Research Center, Ajou University Medical CenterDepartment of New Biology, Daegu Gyeongbuk Institute of Science & TechnologyDepartment of Physics and Chemistry, Daegu Gyeongbuk Institute of Science & TechnologyDepartment of Physics and Chemistry, Daegu Gyeongbuk Institute of Science & TechnologyDepartment of Physics and Chemistry, Daegu Gyeongbuk Institute of Science & TechnologyInflamm-Aging Translational Research Center, Ajou University Medical CenterInflamm-Aging Translational Research Center, Ajou University Medical CenterInflamm-Aging Translational Research Center, Ajou University Medical CenterInflamm-Aging Translational Research Center, Ajou University Medical CenterDepartment of Molecular Medicine, College of Medicine, Inha UniversityInflamm-Aging Translational Research Center, Ajou University Medical CenterInflamm-Aging Translational Research Center, Ajou University Medical CenterAbstract The biological process of aging is thought to result in part from accumulation of senescent cells in organs. However, the present study identified a subset of fibroblasts and smooth muscle cells which are the major constituents of organ stroma neither proliferative nor senescent in tissues of the elderly, which we termed “mid-old status” cells. Upregulation of pro-inflammatory genes (IL1B and SAA1) and downregulation of anti-inflammatory genes (SLIT2 and CXCL12) were detected in mid-old cells. In the stroma, SAA1 promotes development of the inflammatory microenvironment via upregulation of MMP9, which decreases the stability of epithelial cells present on the basement membrane, decreasing epithelial cell function. Remarkably, the microenvironmental change and the functional decline of mid-old cells could be reversed by a young cell-originated protein, SLIT2. Our data identify functional reversion of mid-old cells as a potential method to prevent or ameliorate aspects of aging-related tissue dysfunction.https://doi.org/10.1038/s41467-023-43491-w |
| spellingShingle | Young Hwa Kim Young-Kyoung Lee Soon Sang Park So Hyun Park So Yeong Eom Young-Sam Lee Wonhee John Lee Juhee Jang Daeha Seo Hee Young Kang Jin Cheol Kim Su Bin Lim Gyesoon Yoon Hong Seok Kim Jang-Hee Kim Tae Jun Park Mid-old cells are a potential target for anti-aging interventions in the elderly Nature Communications |
| title | Mid-old cells are a potential target for anti-aging interventions in the elderly |
| title_full | Mid-old cells are a potential target for anti-aging interventions in the elderly |
| title_fullStr | Mid-old cells are a potential target for anti-aging interventions in the elderly |
| title_full_unstemmed | Mid-old cells are a potential target for anti-aging interventions in the elderly |
| title_short | Mid-old cells are a potential target for anti-aging interventions in the elderly |
| title_sort | mid old cells are a potential target for anti aging interventions in the elderly |
| url | https://doi.org/10.1038/s41467-023-43491-w |
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