Clinical and Histopathological Findings of Ectopic Pregnancy Cases- A Retrospective Study from a Tertiary Care Hospital, Andhra Pradesh, India
Introduction: Ectopic Pregnancy (EP) is defined as a pregnancy that occurs in ectopic location, that is, outside the cavity of uterus. It is one of the leading causes of mortality in the first trimester of pregnancy and one of indication for emergency laparotomy. Timely diagnosis is extremely cr...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Pvt. Ltd.
2022-07-01
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Series: | National Journal of Laboratory Medicine |
Subjects: | |
Online Access: | https://www.njlm.net/articles/PDF/2638/52700_CE[Ra1]_F[SH]_PF1(AKA_SHU)_PFA(SHU)_PB(AKA_SHU)_PN(SHU).pdf |
Summary: | Introduction: Ectopic Pregnancy (EP) is defined as a pregnancy
that occurs in ectopic location, that is, outside the cavity of
uterus. It is one of the leading causes of mortality in the first
trimester of pregnancy and one of indication for emergency
laparotomy. Timely diagnosis is extremely crucial as delay in
diagnosis can lead to mortality. Diagnosing ectopic pregnancy
is quiet challenging as there are many conditions which have
similar presentation and may not require surgical management.
Histopathology is required for confirmation of ectopic pregnancy
by identifying trophoblastic tissue in ectopic location, since there
are other conditions like haematosalpinx, ruptured haemorrhagic
corpus luteum which can have similar presentation clinically.
Aim: To analyse the clinicopathological features of cases clinically
diagnosed as ectopic pregnancy and estimate the percentage of
cases which were confirmed on histopathology and assess the
percentage of cases which were negative on histopathology.
Materials and Methods: This was a retrospective observational
study conducted on three years data collected retrospectively
between July 2017 to June 2020. Clinical details like age of the
patient, parity, gestational age, previous history of any associated
risk factors for ectopic pregnancy, were obtained from patient
requisition forms and pathology records. Haematoxylin and
Eosin (H&E) stained sections were reviewed. Descriptive analysis
was done. Data entry was made in Microsoft (MS) excel sheet.
Frequencies and percentages were calculated.
Results: Total of 128 cases (mean age 25.8±4.87 years) data
was analysed in this study, most women were between 21-30
years 97 (75.7%), with mean age of 25.8 years and presented
in 2nd pregnancy 40 (46.5%) out of 86 cases where details were
known and in 6th week of gestation 28 (35.8%) out of 78 cases
where details were known with mean gestational age of 7.2
weeks. Most common risk factors were previous abortions and
previous caesarean section 36 (43.9%) out of 82 cases where
details were known. Fallopian tube was the most common site
112 (99.1%) out of 113 cases. On histopathological examination,
trophoblastic tissue was identified in 116 (90.6%) cases out
of 128 cases. Total 12 (11.7%) cases showed no evidence of
trophoblastic tissues, of these 3 (25%) cases showed ruptured
corpus luteum, 7 (58.3%) showed haematosalpinx, and 2
(16.66%) cases showed chronic salpingitis changes.
Conclusion: Ectopic pregnancy was most frequent in women
between 21-30 years, in 2nd pregnancy and in 6th week of
gestation. Most common risk factors were previous abortions
and previous caesarean section. Fallopian tube was the
most common site. Ectopic pregnancy was confirmed on
histopathological examination, 90.6% cases. A total of 11.7%
cases which showed no evidence of trophoblastic tissues, were
cases of haematosalpinx, ruptured haemorrhagic corpus luteum
and chronic salpingitis and they presented clinically as ectopic
pregnancy |
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ISSN: | 2277-8551 2455-6882 |