Non-coding RNAs and glioma: Focus on cancer stem cells
Glioblastoma and gliomas can have a wide range of histopathologic subtypes. These heterogeneous histologic phenotypes originate from tumor cells with the distinct functions of tumorigenesis and self-renewal, called glioma stem cells (GSCs). GSCs are characterized based on multi-layered epigenetic me...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Molecular Therapy: Oncolytics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770522001176 |
| _version_ | 1811250645000257536 |
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| author | Ali Rajabi Mehrdad Kayedi Shiva Rahimi Fatemeh Dashti Seyed Mohammad Ali Mirazimi Mina Homayoonfal Seyed Mohammad Amin Mahdian Michael R. Hamblin Omid Reza Tamtaji Ali Afrasiabi Ameneh Jafari Hamed Mirzaei |
| author_facet | Ali Rajabi Mehrdad Kayedi Shiva Rahimi Fatemeh Dashti Seyed Mohammad Ali Mirazimi Mina Homayoonfal Seyed Mohammad Amin Mahdian Michael R. Hamblin Omid Reza Tamtaji Ali Afrasiabi Ameneh Jafari Hamed Mirzaei |
| author_sort | Ali Rajabi |
| collection | DOAJ |
| description | Glioblastoma and gliomas can have a wide range of histopathologic subtypes. These heterogeneous histologic phenotypes originate from tumor cells with the distinct functions of tumorigenesis and self-renewal, called glioma stem cells (GSCs). GSCs are characterized based on multi-layered epigenetic mechanisms, which control the expression of many genes. This epigenetic regulatory mechanism is often based on functional non-coding RNAs (ncRNAs). ncRNAs have become increasingly important in the pathogenesis of human cancer and work as oncogenes or tumor suppressors to regulate carcinogenesis and progression. These RNAs by being involved in chromatin remodeling and modification, transcriptional regulation, and alternative splicing of pre-mRNA, as well as mRNA stability and protein translation, play a key role in tumor development and progression. Numerous studies have been performed to try to understand the dysregulation pattern of these ncRNAs in tumors and cancer stem cells (CSCs), which show robust differentiation and self-regeneration capacity. This review provides recent findings on the role of ncRNAs in glioma development and progression, particularly their effects on CSCs, thus accelerating the clinical implementation of ncRNAs as promising tumor biomarkers and therapeutic targets. |
| first_indexed | 2024-04-12T16:07:45Z |
| format | Article |
| id | doaj.art-21898c45f3aa42d3b9f56172b39fe192 |
| institution | Directory Open Access Journal |
| issn | 2372-7705 |
| language | English |
| last_indexed | 2024-04-12T16:07:45Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncolytics |
| spelling | doaj.art-21898c45f3aa42d3b9f56172b39fe1922022-12-22T03:25:59ZengElsevierMolecular Therapy: Oncolytics2372-77052022-12-0127100123Non-coding RNAs and glioma: Focus on cancer stem cellsAli Rajabi0Mehrdad Kayedi1Shiva Rahimi2Fatemeh Dashti3Seyed Mohammad Ali Mirazimi4Mina Homayoonfal5Seyed Mohammad Amin Mahdian6Michael R. Hamblin7Omid Reza Tamtaji8Ali Afrasiabi9Ameneh Jafari10Hamed Mirzaei11School of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Student Research Committee, Kashan University of Medical Sciences, Kashan, IranDepartment of Radiology, Shiraz University of Medical Sciences, Shiraz, IranSchool of Medicine,Fasa University of Medical Sciences, Fasa, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Student Research Committee, Kashan University of Medical Sciences, Kashan, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Student Research Committee, Kashan University of Medical Sciences, Kashan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranDepartment of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South AfricaElectrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran; Corresponding author Ali Afrasiabi, Department of Internal Medicine, Iran university of medical sciences, Tehran, Iran.Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author Ameneh Jafari, Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran; Corresponding author Hamed Mirzaei, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.;Glioblastoma and gliomas can have a wide range of histopathologic subtypes. These heterogeneous histologic phenotypes originate from tumor cells with the distinct functions of tumorigenesis and self-renewal, called glioma stem cells (GSCs). GSCs are characterized based on multi-layered epigenetic mechanisms, which control the expression of many genes. This epigenetic regulatory mechanism is often based on functional non-coding RNAs (ncRNAs). ncRNAs have become increasingly important in the pathogenesis of human cancer and work as oncogenes or tumor suppressors to regulate carcinogenesis and progression. These RNAs by being involved in chromatin remodeling and modification, transcriptional regulation, and alternative splicing of pre-mRNA, as well as mRNA stability and protein translation, play a key role in tumor development and progression. Numerous studies have been performed to try to understand the dysregulation pattern of these ncRNAs in tumors and cancer stem cells (CSCs), which show robust differentiation and self-regeneration capacity. This review provides recent findings on the role of ncRNAs in glioma development and progression, particularly their effects on CSCs, thus accelerating the clinical implementation of ncRNAs as promising tumor biomarkers and therapeutic targets.http://www.sciencedirect.com/science/article/pii/S2372770522001176MT: Non-coding RNAsGliomaCancer stem cells |
| spellingShingle | Ali Rajabi Mehrdad Kayedi Shiva Rahimi Fatemeh Dashti Seyed Mohammad Ali Mirazimi Mina Homayoonfal Seyed Mohammad Amin Mahdian Michael R. Hamblin Omid Reza Tamtaji Ali Afrasiabi Ameneh Jafari Hamed Mirzaei Non-coding RNAs and glioma: Focus on cancer stem cells Molecular Therapy: Oncolytics MT: Non-coding RNAs Glioma Cancer stem cells |
| title | Non-coding RNAs and glioma: Focus on cancer stem cells |
| title_full | Non-coding RNAs and glioma: Focus on cancer stem cells |
| title_fullStr | Non-coding RNAs and glioma: Focus on cancer stem cells |
| title_full_unstemmed | Non-coding RNAs and glioma: Focus on cancer stem cells |
| title_short | Non-coding RNAs and glioma: Focus on cancer stem cells |
| title_sort | non coding rnas and glioma focus on cancer stem cells |
| topic | MT: Non-coding RNAs Glioma Cancer stem cells |
| url | http://www.sciencedirect.com/science/article/pii/S2372770522001176 |
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