A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives
The protonation of N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives in aqueous acids (H2SO4) media was investigated, using a spectrophotometric method. The investigated compounds have two protonation processes. The first protonation process occurs in weakly acidic aqueous solutions (pH range) an...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2000-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.yu/HtDocs/SHD/Vol65/No1-Pdf/V65-No1-04.zip |
| _version_ | 1811246219090984960 |
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| author | NADA U. PERISIC-JANJIC JEVREM D. JANJIC MARIJA LAZAREVIC |
| author_facet | NADA U. PERISIC-JANJIC JEVREM D. JANJIC MARIJA LAZAREVIC |
| author_sort | NADA U. PERISIC-JANJIC |
| collection | DOAJ |
| description | The protonation of N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives in aqueous acids (H2SO4) media was investigated, using a spectrophotometric method. The investigated compounds have two protonation processes. The first protonation process occurs in weakly acidic aqueous solutions (pH range) and refers to the protonation of the benzimidazole part of the molecule. The second protonation process occurs in concentrated sulfuric acid solutions and refers to protonation of the amide group. The protonation constants of the second process were calculated by the Hammett and Cox-Yates method. The effect of chemical structure on the ionisation constants is discussed. A correlation between the protonation constants and antimicrobial activity was established. |
| first_indexed | 2024-04-12T14:50:26Z |
| format | Article |
| id | doaj.art-2189ef25da1d4a2f9d82b6e68d102905 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-04-12T14:50:26Z |
| publishDate | 2000-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-2189ef25da1d4a2f9d82b6e68d1029052022-12-22T03:28:28ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392000-01-016513745A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivativesNADA U. PERISIC-JANJICJEVREM D. JANJICMARIJA LAZAREVICThe protonation of N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives in aqueous acids (H2SO4) media was investigated, using a spectrophotometric method. The investigated compounds have two protonation processes. The first protonation process occurs in weakly acidic aqueous solutions (pH range) and refers to the protonation of the benzimidazole part of the molecule. The second protonation process occurs in concentrated sulfuric acid solutions and refers to protonation of the amide group. The protonation constants of the second process were calculated by the Hammett and Cox-Yates method. The effect of chemical structure on the ionisation constants is discussed. A correlation between the protonation constants and antimicrobial activity was established.http://www.shd.org.yu/HtDocs/SHD/Vol65/No1-Pdf/V65-No1-04.zipspectrophotometryN-[1-(benzimidazol)1-yl]methylbenzamide derivativesprotonation constantsantimicrobial activity |
| spellingShingle | NADA U. PERISIC-JANJIC JEVREM D. JANJIC MARIJA LAZAREVIC A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives Journal of the Serbian Chemical Society spectrophotometry N-[1-(benzimidazol)1-yl]methylbenzamide derivatives protonation constants antimicrobial activity |
| title | A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives |
| title_full | A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives |
| title_fullStr | A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives |
| title_full_unstemmed | A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives |
| title_short | A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives |
| title_sort | spectrophotometric study of the protonation processes of some n 1 benzimidazol 1 yl methylbenzamide derivatives |
| topic | spectrophotometry N-[1-(benzimidazol)1-yl]methylbenzamide derivatives protonation constants antimicrobial activity |
| url | http://www.shd.org.yu/HtDocs/SHD/Vol65/No1-Pdf/V65-No1-04.zip |
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