Comparison of Intravenous Metoclopramide and Acetaminophen in Primary Headaches: a Randomized Controlled Trial
Introduction:Â Headache is the most common neurologic symptom among referees to the emergency department (ED), while the best treatment has not yet been found. Therefore, in the present study pain relief effects of metoclopramide and acetaminophen were compared in patients suffered acute primary hea...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shahid Beheshti University of Medical Sciences
2018-12-01
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| Series: | Archives of Academic Emergency Medicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/269 |
| _version_ | 1818538603792302080 |
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| author | Gholamreza Faridaalaee Seyed Hesam Rahmani Hamidreza Mehryar Shahab Bina Shishavan Seyedeh Zahra Merghati Mohammad Amin Valizade Hasanloei Bahman Naghipour Farzad Rahmani |
| author_facet | Gholamreza Faridaalaee Seyed Hesam Rahmani Hamidreza Mehryar Shahab Bina Shishavan Seyedeh Zahra Merghati Mohammad Amin Valizade Hasanloei Bahman Naghipour Farzad Rahmani |
| author_sort | Gholamreza Faridaalaee |
| collection | DOAJ |
| description | Introduction: Headache is the most common neurologic symptom among referees to the emergency department (ED), while the best treatment has not yet been found. Therefore, in the present study pain relief effects of metoclopramide and acetaminophen were compared in patients suffered acute primary headache. Methods: This study was a double-blind randomized clinical trial performed in Imam Khomeini Hospital, Urmia, Iran, through July to October 2014. All adult patients, with acute primary (migraine, tension type and cluster) headache referred to the ED were included in this study. Pain Severity was measured with 10 centimeters numeric rating scales. The patients were randomized in to two groups of intravenous (IV) metoclopramide (10 milligrams) and acetaminophen (1 gram). Pain score, success rate, and complication of drugs were compared within administration time and 15, 30, 60, as well as 120 minutes after medication. Results: 100 patients were equally categorized in to two groups (mean age of 32 ± 13.2 years; 51.2% male). Initial pain score in metoclopramide and acetaminophen groups were 9.1 and 9.4, respectively (p=0.46). IV metoclopramide did not have any analgesic effect at 15 minutes, but had good effect at 30 minutes. While, the analgesic effect of acetaminophen initiated after 15 minutes. After 2 hours, both drugs had good treatment effect on primary headaches (p<0.001). Conclusion: The present study demonstrated that efficacy of metoclopramide for pain relief in primary headaches is lower than acetaminophen. In this regard, success rate of acetaminophen was 42.0% versus 0% for metoclopramide within 15 minutes. The efficacy of acetaminophen continued until 60 minutes. |
| first_indexed | 2024-12-11T21:31:06Z |
| format | Article |
| id | doaj.art-218b10ea678b4542abc19da7aec3c620 |
| institution | Directory Open Access Journal |
| issn | 2645-4904 |
| language | English |
| last_indexed | 2024-12-11T21:31:06Z |
| publishDate | 2018-12-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Archives of Academic Emergency Medicine |
| spelling | doaj.art-218b10ea678b4542abc19da7aec3c6202022-12-22T00:50:11ZengShahid Beheshti University of Medical SciencesArchives of Academic Emergency Medicine2645-49042018-12-013210.22037/aaem.v3i2.269Comparison of Intravenous Metoclopramide and Acetaminophen in Primary Headaches: a Randomized Controlled TrialGholamreza Faridaalaee0Seyed Hesam Rahmani1Hamidreza Mehryar2Shahab Bina Shishavan3Seyedeh Zahra Merghati4Mohammad Amin Valizade Hasanloei5Bahman Naghipour6Farzad Rahmani7Department of Emergency Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IR IranDepartment of Emergency Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IR IranDepartment of Emergency Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IR IranDepartment of Emergency Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IR IranDepartment of Internal Surgery, School of Nursing and Midwifery, International branch of Urmia University of Medical Sci-ences, Urmia, IR IranDepartment of Anesthesiology, Urmia University of Medical Sciences, Urmia, IR IranDepartment of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, IR IranDepartment of Emergency Medicine, Tabriz University of Medical Sciences, Tabriz, IranIntroduction: Headache is the most common neurologic symptom among referees to the emergency department (ED), while the best treatment has not yet been found. Therefore, in the present study pain relief effects of metoclopramide and acetaminophen were compared in patients suffered acute primary headache. Methods: This study was a double-blind randomized clinical trial performed in Imam Khomeini Hospital, Urmia, Iran, through July to October 2014. All adult patients, with acute primary (migraine, tension type and cluster) headache referred to the ED were included in this study. Pain Severity was measured with 10 centimeters numeric rating scales. The patients were randomized in to two groups of intravenous (IV) metoclopramide (10 milligrams) and acetaminophen (1 gram). Pain score, success rate, and complication of drugs were compared within administration time and 15, 30, 60, as well as 120 minutes after medication. Results: 100 patients were equally categorized in to two groups (mean age of 32 ± 13.2 years; 51.2% male). Initial pain score in metoclopramide and acetaminophen groups were 9.1 and 9.4, respectively (p=0.46). IV metoclopramide did not have any analgesic effect at 15 minutes, but had good effect at 30 minutes. While, the analgesic effect of acetaminophen initiated after 15 minutes. After 2 hours, both drugs had good treatment effect on primary headaches (p<0.001). Conclusion: The present study demonstrated that efficacy of metoclopramide for pain relief in primary headaches is lower than acetaminophen. In this regard, success rate of acetaminophen was 42.0% versus 0% for metoclopramide within 15 minutes. The efficacy of acetaminophen continued until 60 minutes.https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/269MetoclopramideAcetaminophenHeadacheMigraineAcute Pain |
| spellingShingle | Gholamreza Faridaalaee Seyed Hesam Rahmani Hamidreza Mehryar Shahab Bina Shishavan Seyedeh Zahra Merghati Mohammad Amin Valizade Hasanloei Bahman Naghipour Farzad Rahmani Comparison of Intravenous Metoclopramide and Acetaminophen in Primary Headaches: a Randomized Controlled Trial Archives of Academic Emergency Medicine Metoclopramide Acetaminophen Headache Migraine Acute Pain |
| title | Comparison of Intravenous Metoclopramide and Acetaminophen in Primary Headaches: a Randomized Controlled Trial |
| title_full | Comparison of Intravenous Metoclopramide and Acetaminophen in Primary Headaches: a Randomized Controlled Trial |
| title_fullStr | Comparison of Intravenous Metoclopramide and Acetaminophen in Primary Headaches: a Randomized Controlled Trial |
| title_full_unstemmed | Comparison of Intravenous Metoclopramide and Acetaminophen in Primary Headaches: a Randomized Controlled Trial |
| title_short | Comparison of Intravenous Metoclopramide and Acetaminophen in Primary Headaches: a Randomized Controlled Trial |
| title_sort | comparison of intravenous metoclopramide and acetaminophen in primary headaches a randomized controlled trial |
| topic | Metoclopramide Acetaminophen Headache Migraine Acute Pain |
| url | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/269 |
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