Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
Abstract Background Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate t...
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3241 |
| _version_ | 1797632528547315712 |
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| author | Yang Wang Yun Qin Hui Li Dezhong Yao Bo Sun Jinnan Gong Yu Dai Chao Wen Lingrui Zhang Chenchen Zhang Cheng Luo Tianmin Zhu |
| author_facet | Yang Wang Yun Qin Hui Li Dezhong Yao Bo Sun Jinnan Gong Yu Dai Chao Wen Lingrui Zhang Chenchen Zhang Cheng Luo Tianmin Zhu |
| author_sort | Yang Wang |
| collection | DOAJ |
| description | Abstract Background Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modulatory effects of acupuncture on the functional interactions among the addiction‐related networks in adolescents with IA. Methods Thirty individuals with IA and thirty age‐ and sex‐matched healthy control subjects (HCs) were recruited. Subjects with IA were given a 40‐day acupuncture treatment, and resting‐state functional magnetic resonance imaging (fMRI) data were collected before and after acupuncture sessions. HCs received no treatment and underwent one fMRI scan after enrollment. The intergroup differences in functional connectivity (FC) among the subcortical nucleus (SN) and fronto‐parietal network (FPN) were compared between HCs and subjects with IA at baseline. Then, the intragroup FC differences between the pre‐ and post‐treatment were analyzed in the IA group. A multiple linear regression model was further employed to fit the FC changes to symptom relief in the IA group. Results In comparison to HCs, subjects with IA exhibited significantly heightened FC within and between the SN and FPN at baseline. After 40 days of acupuncture treatment, the FC within the FPN and between the SN and FPN were significantly decreased in individuals with IA. Symptom improvement in subjects with IA was well fitted by the decrease in FC between the left midbrain and ventral prefrontal cortex and between the left thalamus and ventral anterior prefrontal cortex. Conclusion These findings confirmed the modulatory effects of acupuncture on the aberrant functional interactions among the SN and FPN, which may partly reflect the neurophysiological mechanism of acupuncture for IA. |
| first_indexed | 2024-03-11T11:39:17Z |
| format | Article |
| id | doaj.art-218c53fd0aae47528c92fe0b8831641b |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-11T11:39:17Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-218c53fd0aae47528c92fe0b8831641b2023-11-10T06:53:59ZengWileyBrain and Behavior2162-32792023-11-011311n/an/a10.1002/brb3.3241Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addictionYang Wang0Yun Qin1Hui Li2Dezhong Yao3Bo Sun4Jinnan Gong5Yu Dai6Chao Wen7Lingrui Zhang8Chenchen Zhang9Cheng Luo10Tianmin Zhu11School of Sports Medicine and Health Chengdu Sport University Chengdu ChinaKey Laboratory for NeuroInformation of Ministry of Education University of Electronic Science and Technology of China Chengdu ChinaSchool of Medicine Chengdu University Chengdu ChinaKey Laboratory for NeuroInformation of Ministry of Education University of Electronic Science and Technology of China Chengdu ChinaKey Laboratory for NeuroInformation of Ministry of Education University of Electronic Science and Technology of China Chengdu ChinaKey Laboratory for NeuroInformation of Ministry of Education University of Electronic Science and Technology of China Chengdu ChinaDepartment of Chinese Medicine Chengdu Eighth People's Hospital Chengdu ChinaDepartment of Rehabilitation Zigong Fifth People's Hospital Zigong ChinaDepartment of Medicine Leshan Vocational and Technical College Leshan ChinaDepartment of Rehabilitation TCM Hospital of Longquanyi District Chengdu ChinaKey Laboratory for NeuroInformation of Ministry of Education University of Electronic Science and Technology of China Chengdu ChinaSchool of Rehabilitation and Health Preservation Chengdu University of TCM Chengdu ChinaAbstract Background Internet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modulatory effects of acupuncture on the functional interactions among the addiction‐related networks in adolescents with IA. Methods Thirty individuals with IA and thirty age‐ and sex‐matched healthy control subjects (HCs) were recruited. Subjects with IA were given a 40‐day acupuncture treatment, and resting‐state functional magnetic resonance imaging (fMRI) data were collected before and after acupuncture sessions. HCs received no treatment and underwent one fMRI scan after enrollment. The intergroup differences in functional connectivity (FC) among the subcortical nucleus (SN) and fronto‐parietal network (FPN) were compared between HCs and subjects with IA at baseline. Then, the intragroup FC differences between the pre‐ and post‐treatment were analyzed in the IA group. A multiple linear regression model was further employed to fit the FC changes to symptom relief in the IA group. Results In comparison to HCs, subjects with IA exhibited significantly heightened FC within and between the SN and FPN at baseline. After 40 days of acupuncture treatment, the FC within the FPN and between the SN and FPN were significantly decreased in individuals with IA. Symptom improvement in subjects with IA was well fitted by the decrease in FC between the left midbrain and ventral prefrontal cortex and between the left thalamus and ventral anterior prefrontal cortex. Conclusion These findings confirmed the modulatory effects of acupuncture on the aberrant functional interactions among the SN and FPN, which may partly reflect the neurophysiological mechanism of acupuncture for IA.https://doi.org/10.1002/brb3.3241acupunctureinternet addictionlarge‐scale networkmultiple linear regression |
| spellingShingle | Yang Wang Yun Qin Hui Li Dezhong Yao Bo Sun Jinnan Gong Yu Dai Chao Wen Lingrui Zhang Chenchen Zhang Cheng Luo Tianmin Zhu Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction Brain and Behavior acupuncture internet addiction large‐scale network multiple linear regression |
| title | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
| title_full | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
| title_fullStr | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
| title_full_unstemmed | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
| title_short | Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction |
| title_sort | acupuncture modulates the functional connectivity among the subcortical nucleus and fronto parietal network in adolescents with internet addiction |
| topic | acupuncture internet addiction large‐scale network multiple linear regression |
| url | https://doi.org/10.1002/brb3.3241 |
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