Chk1 Inhibition Hinders the Restoration of H3.1K56 and H3.3K56 Acetylation and Reprograms Gene Transcription After DNA Damage Repair

Chk1 Inhibition Hinders the Restoration of H3.1K56 and H3.3K56 Acetylation and Reprograms Gene Transcription After DNA Damage Repair

H3K56 acetylation (H3K56Ac) was reported to play a critical role in chromatin assembly; thus, H3K56ac participates in the regulation of DNA replication, cell cycle progression, DNA repair, and transcriptional activation. To investigate the influence of DNA damage regulators on the acetylation of his...

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Bibliographic Details
Main Authors: Nan Ding, Zhiang Shao, Fangyun Yuan, Pei Qu, Ping Li, Dong Lu, Jufang Wang, Qianzheng Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
posttranslational modification (PMT)
H3K56 acetylation
radiation
Chk1
chromatin assembly
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.862592/full

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