Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke

Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke

Abstract Background Several therapeutic strategies to rescue the brain from ischemic injury have improved outcomes after stroke; however, there is no treatment as yet for reperfusion injury, the secondary damage caused by necessary revascularization. Recently we characterized ammonium tetrathiomolyb...

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Bibliographic Details
Main Authors: Bruna Pescador Mendonça, Juliano Dos Santos Cardoso, Monique Michels, Ana Carolina Vieira, Diogo Wendhausen, Andressa Manfredini, Mervyn Singer, Felipe Dal-Pizzol, Alex Dyson
Format: Article
Language:English
Published: SpringerOpen 2020-04-01
Series:Intensive Care Medicine Experimental
Subjects:
Ischemia
Reperfusion
Brain
Oxidative stress
Reactive oxygen species
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s40635-020-00300-8

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