Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience
Psychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for Alzheimer’s disease. Stress resilience is a positive o...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2017-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/1546125 |
| _version_ | 1798043477578088448 |
|---|---|
| author | Mathilde S. Henry Louis Gendron Marie-Eve Tremblay Guy Drolet |
| author_facet | Mathilde S. Henry Louis Gendron Marie-Eve Tremblay Guy Drolet |
| author_sort | Mathilde S. Henry |
| collection | DOAJ |
| description | Psychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for Alzheimer’s disease. Stress resilience is a positive outcome that is associated with preserved cognition and healthy aging. Resilience presents psychological and biological characteristics intrinsic to an individual conferring protection against the development of psychopathologies in the face of adversity. How can we promote or improve resilience to chronic stress? Numerous studies have proposed mechanisms that could trigger this desirable process. The roles of enkephalin transmission in the control of pain, physiological functions, like respiration, and affective disorders have been studied for more than 30 years. However, their role in the resilience to chronic stress has received much less attention. This review presents the evidence for an emerging involvement of enkephalin signaling through its two associated opioid receptors, μ opioid peptide receptor and δ opioid peptide receptor, in the natural adaptation to stressful lifestyles. |
| first_indexed | 2024-04-11T22:50:36Z |
| format | Article |
| id | doaj.art-21911babf75048e1b2e9d984a1fddb77 |
| institution | Directory Open Access Journal |
| issn | 2090-5904 1687-5443 |
| language | English |
| last_indexed | 2024-04-11T22:50:36Z |
| publishDate | 2017-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj.art-21911babf75048e1b2e9d984a1fddb772022-12-22T03:58:36ZengHindawi LimitedNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/15461251546125Enkephalins: Endogenous Analgesics with an Emerging Role in Stress ResilienceMathilde S. Henry0Louis Gendron1Marie-Eve Tremblay2Guy Drolet3Axe Neurosciences, Centre de Recherche du CHU de Québec – Université Laval, Québec, QC, CanadaDépartement de pharmacologie-physiologie, Centre de Recherche du CHU de Sherbrooke, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, CanadaAxe Neurosciences, Centre de Recherche du CHU de Québec – Université Laval, Québec, QC, CanadaAxe Neurosciences, Centre de Recherche du CHU de Québec – Université Laval, Québec, QC, CanadaPsychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for Alzheimer’s disease. Stress resilience is a positive outcome that is associated with preserved cognition and healthy aging. Resilience presents psychological and biological characteristics intrinsic to an individual conferring protection against the development of psychopathologies in the face of adversity. How can we promote or improve resilience to chronic stress? Numerous studies have proposed mechanisms that could trigger this desirable process. The roles of enkephalin transmission in the control of pain, physiological functions, like respiration, and affective disorders have been studied for more than 30 years. However, their role in the resilience to chronic stress has received much less attention. This review presents the evidence for an emerging involvement of enkephalin signaling through its two associated opioid receptors, μ opioid peptide receptor and δ opioid peptide receptor, in the natural adaptation to stressful lifestyles.http://dx.doi.org/10.1155/2017/1546125 |
| spellingShingle | Mathilde S. Henry Louis Gendron Marie-Eve Tremblay Guy Drolet Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience Neural Plasticity |
| title | Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience |
| title_full | Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience |
| title_fullStr | Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience |
| title_full_unstemmed | Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience |
| title_short | Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience |
| title_sort | enkephalins endogenous analgesics with an emerging role in stress resilience |
| url | http://dx.doi.org/10.1155/2017/1546125 |
| work_keys_str_mv | AT mathildeshenry enkephalinsendogenousanalgesicswithanemergingroleinstressresilience AT louisgendron enkephalinsendogenousanalgesicswithanemergingroleinstressresilience AT marieevetremblay enkephalinsendogenousanalgesicswithanemergingroleinstressresilience AT guydrolet enkephalinsendogenousanalgesicswithanemergingroleinstressresilience |