GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD
Introduction: The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma in dynamic during treatment period.Methods: Performed 24-week prospective in...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2014-02-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/16 |
| _version_ | 1827991637634056192 |
|---|---|
| author | Ye. S. Kulikov L. M. Ogorodova M. B. Freidin I. V. Saltikova I. A. Deyev P. A. Selivanova |
| author_facet | Ye. S. Kulikov L. M. Ogorodova M. B. Freidin I. V. Saltikova I. A. Deyev P. A. Selivanova |
| author_sort | Ye. S. Kulikov |
| collection | DOAJ |
| description | Introduction: The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma in dynamic during treatment period.Methods: Performed 24-week prospective interventional study in parallel groups. Severe asthma patients was aposterior divided at therapy sensitive and resistant patients according to ATS criteria. Global transcriptome profile was characterized using the Affymetrix HuGene ST1.0 chip. Cluster analysis was performed.Results and conclusion: According to our data several mechanisms of therapy resistance may be considered: increased levels of nitric oxide and beta2-agonists nitration, dysregulation of endogenous steroids secretion and involvement in the pathogenesis of Staphylococcus aureus. Absence of suppression of gene expression KEGG-pathway “asthma" may reflect the low efficiency or long period of anti-inflammatory therapy effect realization. |
| first_indexed | 2024-04-10T01:08:23Z |
| format | Article |
| id | doaj.art-2191fbb3c03444fb87f9a8f76fa1db15 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:08:23Z |
| publishDate | 2014-02-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-2191fbb3c03444fb87f9a8f76fa1db152023-03-13T09:58:19ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842014-02-01131475510.20538/1682-0363-2014-1-47-5516GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIODYe. S. Kulikov0L. M. Ogorodova1M. B. Freidin2I. V. Saltikova3I. A. Deyev4P. A. Selivanova5Сибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскНаучно-исследовательский институт медицинской генетики Сибирского отделения РАМНСибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскСибирский государственный медицинский университет, ТомскIntroduction: The leading mechanisms and causes of severe therapy resistant asthma are poorly understood. The aim of this study was to define global patterns of gene expression in adults with severe therapy-resistant asthma in dynamic during treatment period.Methods: Performed 24-week prospective interventional study in parallel groups. Severe asthma patients was aposterior divided at therapy sensitive and resistant patients according to ATS criteria. Global transcriptome profile was characterized using the Affymetrix HuGene ST1.0 chip. Cluster analysis was performed.Results and conclusion: According to our data several mechanisms of therapy resistance may be considered: increased levels of nitric oxide and beta2-agonists nitration, dysregulation of endogenous steroids secretion and involvement in the pathogenesis of Staphylococcus aureus. Absence of suppression of gene expression KEGG-pathway “asthma" may reflect the low efficiency or long period of anti-inflammatory therapy effect realization.https://bulletin.ssmu.ru/jour/article/view/16бронхиальная астматерапиятяжелая бронхиальная астматерапевтическая резистентностьмолекулярные механизмы |
| spellingShingle | Ye. S. Kulikov L. M. Ogorodova M. B. Freidin I. V. Saltikova I. A. Deyev P. A. Selivanova GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD Бюллетень сибирской медицины бронхиальная астма терапия тяжелая бронхиальная астма терапевтическая резистентность молекулярные механизмы |
| title | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_full | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_fullStr | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_full_unstemmed | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_short | GENE EXPRESSION DYNAMICS IN PATIENTS WITH SEVERE THERAPY-RESISTANT ASTHMA DURING TREATMENT PERIOD |
| title_sort | gene expression dynamics in patients with severe therapy resistant asthma during treatment period |
| topic | бронхиальная астма терапия тяжелая бронхиальная астма терапевтическая резистентность молекулярные механизмы |
| url | https://bulletin.ssmu.ru/jour/article/view/16 |
| work_keys_str_mv | AT yeskulikov geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT lmogorodova geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT mbfreidin geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT ivsaltikova geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT iadeyev geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod AT paselivanova geneexpressiondynamicsinpatientswithseveretherapyresistantasthmaduringtreatmentperiod |