Mineral and bone disorder after kidney transplantation: a single-center cohort study
AbstractBackground The assessment and prevention of mineral and bone disorder (MBD) in kidney transplant recipients (KTRs) have not been standardized. This study aimed to evaluate MBD one year after kidney transplantation (KT) and identify the influencing factors of MBD.Methods A total of 95 KTRs in...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2210231 |
| _version_ | 1797658490601209856 |
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| author | Li Sun Zijie Wang Ming Zheng Zhou Hang Jiawen Liu Xiang Gao Zeping Gui Dengyuan Feng Dongliang Zhang Qianguang Han Shuang Fei Hao Chen Jun Tao Zhijian Han Xiaobing Ju Min Gu Ruoyun Tan |
| author_facet | Li Sun Zijie Wang Ming Zheng Zhou Hang Jiawen Liu Xiang Gao Zeping Gui Dengyuan Feng Dongliang Zhang Qianguang Han Shuang Fei Hao Chen Jun Tao Zhijian Han Xiaobing Ju Min Gu Ruoyun Tan |
| author_sort | Li Sun |
| collection | DOAJ |
| description | AbstractBackground The assessment and prevention of mineral and bone disorder (MBD) in kidney transplant recipients (KTRs) have not been standardized. This study aimed to evaluate MBD one year after kidney transplantation (KT) and identify the influencing factors of MBD.Methods A total of 95 KTRs in our center were enrolled. The changes in bone mineral density (BMD) and bone metabolism biochemical markers, including serum calcium (Ca), phosphorus(P), 25-hydroxyvitamin D(25(OH)vitD), intact parathyroid hormone (iPTH), bone alkaline phosphatase, osteocalcin (OC), type I collagen N-terminal peptide and type I collagen C-terminal peptide (CTx), over one year after KT were assessed. The possible influencing factors of BMD were analyzed. The relationships between bone metabolism biochemical markers were evaluated. The indicators between groups with or without iPTH normalization were also compared.Results MBD after KT was manifested as an increased prevalence of hypophosphatemia and bone loss, persistent 25(OH)vitD deficiency, and partially decreased PTH and bone turnover markers (BTMs). Femoral neck BMD was positively correlated with body mass index (BMI) and postoperative 25(OH)vitD, and negatively correlated with postoperative PTH. Lumbar spine BMD was positively correlated with BMI and preoperative TG, and negatively correlated with preoperative OC and CTx. BMD loss was positively associated with glucocorticoid accumulation. Preoperative and postoperative iPTH was negatively correlated with postoperative serum P and 25(OH)vitD, and positively correlated with postoperative Ca and BTMs. The recipients without iPTH normalization, who accounted for 41.0% of all KTRs, presented with higher Ca, lower P, higher BTMs, advanced age, and a higher prevalence of preoperative parathyroid hyperplasia.Conclusions MBD persisted after KT, showing a close relationship with hyperparathyroidism, high bone turnover, and glucocorticoid accumulation. |
| first_indexed | 2024-03-11T17:59:42Z |
| format | Article |
| id | doaj.art-21936338f9d8423ab8b5f0b74ad43774 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-11T17:59:42Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-21936338f9d8423ab8b5f0b74ad437742023-10-17T09:23:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2210231Mineral and bone disorder after kidney transplantation: a single-center cohort studyLi Sun0Zijie Wang1Ming Zheng2Zhou Hang3Jiawen Liu4Xiang Gao5Zeping Gui6Dengyuan Feng7Dongliang Zhang8Qianguang Han9Shuang Fei10Hao Chen11Jun Tao12Zhijian Han13Xiaobing Ju14Min Gu15Ruoyun Tan16Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaAbstractBackground The assessment and prevention of mineral and bone disorder (MBD) in kidney transplant recipients (KTRs) have not been standardized. This study aimed to evaluate MBD one year after kidney transplantation (KT) and identify the influencing factors of MBD.Methods A total of 95 KTRs in our center were enrolled. The changes in bone mineral density (BMD) and bone metabolism biochemical markers, including serum calcium (Ca), phosphorus(P), 25-hydroxyvitamin D(25(OH)vitD), intact parathyroid hormone (iPTH), bone alkaline phosphatase, osteocalcin (OC), type I collagen N-terminal peptide and type I collagen C-terminal peptide (CTx), over one year after KT were assessed. The possible influencing factors of BMD were analyzed. The relationships between bone metabolism biochemical markers were evaluated. The indicators between groups with or without iPTH normalization were also compared.Results MBD after KT was manifested as an increased prevalence of hypophosphatemia and bone loss, persistent 25(OH)vitD deficiency, and partially decreased PTH and bone turnover markers (BTMs). Femoral neck BMD was positively correlated with body mass index (BMI) and postoperative 25(OH)vitD, and negatively correlated with postoperative PTH. Lumbar spine BMD was positively correlated with BMI and preoperative TG, and negatively correlated with preoperative OC and CTx. BMD loss was positively associated with glucocorticoid accumulation. Preoperative and postoperative iPTH was negatively correlated with postoperative serum P and 25(OH)vitD, and positively correlated with postoperative Ca and BTMs. The recipients without iPTH normalization, who accounted for 41.0% of all KTRs, presented with higher Ca, lower P, higher BTMs, advanced age, and a higher prevalence of preoperative parathyroid hyperplasia.Conclusions MBD persisted after KT, showing a close relationship with hyperparathyroidism, high bone turnover, and glucocorticoid accumulation.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2210231Kidney transplantationmineral and bone disorderosteoporosishyperparathyroidism |
| spellingShingle | Li Sun Zijie Wang Ming Zheng Zhou Hang Jiawen Liu Xiang Gao Zeping Gui Dengyuan Feng Dongliang Zhang Qianguang Han Shuang Fei Hao Chen Jun Tao Zhijian Han Xiaobing Ju Min Gu Ruoyun Tan Mineral and bone disorder after kidney transplantation: a single-center cohort study Renal Failure Kidney transplantation mineral and bone disorder osteoporosis hyperparathyroidism |
| title | Mineral and bone disorder after kidney transplantation: a single-center cohort study |
| title_full | Mineral and bone disorder after kidney transplantation: a single-center cohort study |
| title_fullStr | Mineral and bone disorder after kidney transplantation: a single-center cohort study |
| title_full_unstemmed | Mineral and bone disorder after kidney transplantation: a single-center cohort study |
| title_short | Mineral and bone disorder after kidney transplantation: a single-center cohort study |
| title_sort | mineral and bone disorder after kidney transplantation a single center cohort study |
| topic | Kidney transplantation mineral and bone disorder osteoporosis hyperparathyroidism |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2210231 |
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