Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study
Serum biomarkers and lung ultrasound are important measures for prognostication and treatment allocation in patients with COVID-19. Currently, there is a paucity of studies investigating relationships between serum biomarkers and ultrasonographic biomarkers derived from lung ultrasound. This study a...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/4/421 |
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| author | Amne Mousa Siebe G. Blok Dian Karssen Jurjan Aman Jouke T. Annema Harm Jan Bogaard Peter I. Bonta Mark E. Haaksma Micah L. A. Heldeweg Arthur W. E. Lieveld Prabath Nanayakkara Esther J. Nossent Jasper M. Smit Marry R. Smit Alexander P. J. Vlaar Marcus J. Schultz Lieuwe D. J. Bos Frederique Paulus Pieter R. Tuinman Amsterdam UMC COVID-19 Biobank Investigators |
| author_facet | Amne Mousa Siebe G. Blok Dian Karssen Jurjan Aman Jouke T. Annema Harm Jan Bogaard Peter I. Bonta Mark E. Haaksma Micah L. A. Heldeweg Arthur W. E. Lieveld Prabath Nanayakkara Esther J. Nossent Jasper M. Smit Marry R. Smit Alexander P. J. Vlaar Marcus J. Schultz Lieuwe D. J. Bos Frederique Paulus Pieter R. Tuinman Amsterdam UMC COVID-19 Biobank Investigators |
| author_sort | Amne Mousa |
| collection | DOAJ |
| description | Serum biomarkers and lung ultrasound are important measures for prognostication and treatment allocation in patients with COVID-19. Currently, there is a paucity of studies investigating relationships between serum biomarkers and ultrasonographic biomarkers derived from lung ultrasound. This study aims to assess correlations between serum biomarkers and lung ultrasound findings. This study is a secondary analysis of four prospective observational studies in adult patients with COVID-19. Serum biomarkers included markers of epithelial injury, endothelial dysfunction and immune activation. The primary outcome was the correlation between biomarker concentrations and lung ultrasound score assessed with Pearson’s (r) or Spearman’s (r<sub>s</sub>) correlations. Forty-four patients (67 [41–88] years old, 25% female, 52% ICU patients) were included. GAS6 (r<sub>s</sub> = 0.39), CRP (r<sub>s</sub> = 0.42) and SP-D (r<sub>s</sub> = 0.36) were correlated with lung ultrasound scores. ANG-1 (r<sub>s</sub> = −0.39) was inversely correlated with lung ultrasound scores. No correlations were found between lung ultrasound score and several other serum biomarkers. In patients with COVID-19, several serum biomarkers of epithelial injury, endothelial dysfunction and immune activation correlated with lung ultrasound findings. The lack of correlations with certain biomarkers could offer opportunities for precise prognostication and targeted therapeutic interventions by integrating these unlinked biomarkers. |
| first_indexed | 2024-03-07T22:35:15Z |
| format | Article |
| id | doaj.art-2194fee0e1364a328e68fc0f91a227d7 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-07T22:35:15Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2194fee0e1364a328e68fc0f91a227d72024-02-23T15:13:51ZengMDPI AGDiagnostics2075-44182024-02-0114442110.3390/diagnostics14040421Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational StudyAmne Mousa0Siebe G. Blok1Dian Karssen2Jurjan Aman3Jouke T. Annema4Harm Jan Bogaard5Peter I. Bonta6Mark E. Haaksma7Micah L. A. Heldeweg8Arthur W. E. Lieveld9Prabath Nanayakkara10Esther J. Nossent11Jasper M. Smit12Marry R. Smit13Alexander P. J. Vlaar14Marcus J. Schultz15Lieuwe D. J. Bos16Frederique Paulus17Pieter R. Tuinman18Amsterdam UMC COVID-19 Biobank InvestigatorsDepartment of Intensive Care Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsAmsterdam Leiden IC Focused Echography (ALIFE, <uri>www.alifeofpocus.com</uri>), 1081 HV Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsSection Acute Medicine, Department of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsSection Acute Medicine, Department of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Infection and Immunity, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Infection and Immunity, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Infection and Immunity, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Infection and Immunity, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Infection and Immunity, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsSerum biomarkers and lung ultrasound are important measures for prognostication and treatment allocation in patients with COVID-19. Currently, there is a paucity of studies investigating relationships between serum biomarkers and ultrasonographic biomarkers derived from lung ultrasound. This study aims to assess correlations between serum biomarkers and lung ultrasound findings. This study is a secondary analysis of four prospective observational studies in adult patients with COVID-19. Serum biomarkers included markers of epithelial injury, endothelial dysfunction and immune activation. The primary outcome was the correlation between biomarker concentrations and lung ultrasound score assessed with Pearson’s (r) or Spearman’s (r<sub>s</sub>) correlations. Forty-four patients (67 [41–88] years old, 25% female, 52% ICU patients) were included. GAS6 (r<sub>s</sub> = 0.39), CRP (r<sub>s</sub> = 0.42) and SP-D (r<sub>s</sub> = 0.36) were correlated with lung ultrasound scores. ANG-1 (r<sub>s</sub> = −0.39) was inversely correlated with lung ultrasound scores. No correlations were found between lung ultrasound score and several other serum biomarkers. In patients with COVID-19, several serum biomarkers of epithelial injury, endothelial dysfunction and immune activation correlated with lung ultrasound findings. The lack of correlations with certain biomarkers could offer opportunities for precise prognostication and targeted therapeutic interventions by integrating these unlinked biomarkers.https://www.mdpi.com/2075-4418/14/4/421lungultrasonographyepithelial injuryendothelial dysfunctionimmune activationrespiratory failure |
| spellingShingle | Amne Mousa Siebe G. Blok Dian Karssen Jurjan Aman Jouke T. Annema Harm Jan Bogaard Peter I. Bonta Mark E. Haaksma Micah L. A. Heldeweg Arthur W. E. Lieveld Prabath Nanayakkara Esther J. Nossent Jasper M. Smit Marry R. Smit Alexander P. J. Vlaar Marcus J. Schultz Lieuwe D. J. Bos Frederique Paulus Pieter R. Tuinman Amsterdam UMC COVID-19 Biobank Investigators Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study Diagnostics lung ultrasonography epithelial injury endothelial dysfunction immune activation respiratory failure |
| title | Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study |
| title_full | Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study |
| title_fullStr | Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study |
| title_full_unstemmed | Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study |
| title_short | Correlation between Serum Biomarkers and Lung Ultrasound in COVID-19: An Observational Study |
| title_sort | correlation between serum biomarkers and lung ultrasound in covid 19 an observational study |
| topic | lung ultrasonography epithelial injury endothelial dysfunction immune activation respiratory failure |
| url | https://www.mdpi.com/2075-4418/14/4/421 |
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