Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular Carcinoma
Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC), the leading cause of cancer-related death worldwide. Despite progress in the prevention and therapy of HCC, high incidence and recurrence rates of HCC remain big threats, resulting...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/12/9/945 |
| _version_ | 1827707433571581952 |
|---|---|
| author | Chiao-Fang Teng Han-Chieh Wu Ih-Jen Su Long-Bin Jeng |
| author_facet | Chiao-Fang Teng Han-Chieh Wu Ih-Jen Su Long-Bin Jeng |
| author_sort | Chiao-Fang Teng |
| collection | DOAJ |
| description | Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC), the leading cause of cancer-related death worldwide. Despite progress in the prevention and therapy of HCC, high incidence and recurrence rates of HCC remain big threats, resulting in poor patient survival. Effective biomarkers and targets of HCC are therefore urgently needed for better management and to improve patient outcomes. Pre-S mutants have been well demonstrated as HBV oncoproteins that play important roles in HCC development through activation of multiple oncogenic signal pathways in hepatocytes, in vitro and in vivo. The presence of pre-S mutants in patients with chronic HBV infection and HBV-related HCC has been associated with a significantly higher risk of HCC development and recurrence after curative surgical resection, respectively. In this review, we summarize the roles of pre-S mutants as biomarkers for predicting HBV-related HCC development and recurrence, and highlight the pre-S mutants-activated oncogenic signal pathways as potential targets for preventing HBV-related HCC development. |
| first_indexed | 2024-03-10T16:47:31Z |
| format | Article |
| id | doaj.art-219819ea4e6e44e6b8ffac4602acf229 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T16:47:31Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-219819ea4e6e44e6b8ffac4602acf2292023-11-20T11:29:36ZengMDPI AGViruses1999-49152020-08-0112994510.3390/v12090945Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular CarcinomaChiao-Fang Teng0Han-Chieh Wu1Ih-Jen Su2Long-Bin Jeng3Graduate Institute of Biomedical Sciences, China Medical University, No.91, Hsueh-Shih Rd., Northern Dist., Taichung City 404, TaiwanNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan 350, TaiwanDepartment of Biotechnology, Southern Taiwan University of Science and Technology, No.1, Nantai St., Yongkang Dist., Tainan City 710, TaiwanOrgan Transplantation Center, China Medical University Hospital, No.2, Yude Rd., North Dist., Taichung City 404, TaiwanChronic hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC), the leading cause of cancer-related death worldwide. Despite progress in the prevention and therapy of HCC, high incidence and recurrence rates of HCC remain big threats, resulting in poor patient survival. Effective biomarkers and targets of HCC are therefore urgently needed for better management and to improve patient outcomes. Pre-S mutants have been well demonstrated as HBV oncoproteins that play important roles in HCC development through activation of multiple oncogenic signal pathways in hepatocytes, in vitro and in vivo. The presence of pre-S mutants in patients with chronic HBV infection and HBV-related HCC has been associated with a significantly higher risk of HCC development and recurrence after curative surgical resection, respectively. In this review, we summarize the roles of pre-S mutants as biomarkers for predicting HBV-related HCC development and recurrence, and highlight the pre-S mutants-activated oncogenic signal pathways as potential targets for preventing HBV-related HCC development.https://www.mdpi.com/1999-4915/12/9/945hepatitis B virushepatocellular carcinomabiomarkerstargetspre-S mutants |
| spellingShingle | Chiao-Fang Teng Han-Chieh Wu Ih-Jen Su Long-Bin Jeng Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular Carcinoma Viruses hepatitis B virus hepatocellular carcinoma biomarkers targets pre-S mutants |
| title | Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular Carcinoma |
| title_full | Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular Carcinoma |
| title_fullStr | Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular Carcinoma |
| title_full_unstemmed | Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular Carcinoma |
| title_short | Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular Carcinoma |
| title_sort | hepatitis b virus pre s mutants as biomarkers and targets for the development and recurrence of hepatocellular carcinoma |
| topic | hepatitis B virus hepatocellular carcinoma biomarkers targets pre-S mutants |
| url | https://www.mdpi.com/1999-4915/12/9/945 |
| work_keys_str_mv | AT chiaofangteng hepatitisbviruspresmutantsasbiomarkersandtargetsforthedevelopmentandrecurrenceofhepatocellularcarcinoma AT hanchiehwu hepatitisbviruspresmutantsasbiomarkersandtargetsforthedevelopmentandrecurrenceofhepatocellularcarcinoma AT ihjensu hepatitisbviruspresmutantsasbiomarkersandtargetsforthedevelopmentandrecurrenceofhepatocellularcarcinoma AT longbinjeng hepatitisbviruspresmutantsasbiomarkersandtargetsforthedevelopmentandrecurrenceofhepatocellularcarcinoma |