Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test
In a recent study, we showed that konjac glucomannan (KGM) inhibits rice gruel-induced postprandial increases in plasma glucose and insulin levels. To extend this research, we investigated the effects of KGM addition to rice gruel on pre- and postprandial concentrations of circulating lipoprotein li...
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MDPI AG
2021-06-01
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| author | Takumi Nagasawa Takao Kimura Akihiro Yoshida Katsuhiko Tsunekawa Osamu Araki Kazumi Ushiki Hirotaka Ishigaki Yoshifumi Shoho Itsumi Suda Suguru Hiramoto Masami Murakami |
| author_facet | Takumi Nagasawa Takao Kimura Akihiro Yoshida Katsuhiko Tsunekawa Osamu Araki Kazumi Ushiki Hirotaka Ishigaki Yoshifumi Shoho Itsumi Suda Suguru Hiramoto Masami Murakami |
| author_sort | Takumi Nagasawa |
| collection | DOAJ |
| description | In a recent study, we showed that konjac glucomannan (KGM) inhibits rice gruel-induced postprandial increases in plasma glucose and insulin levels. To extend this research, we investigated the effects of KGM addition to rice gruel on pre- and postprandial concentrations of circulating lipoprotein lipase (LPL), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), hepatic triglyceride lipase (HTGL), free fatty acids (FFA), and triglycerides (TG). A total of 13 Japanese men, without diabetes, dyslipidemia, or gastrointestinal diseases, interchangeably ingested rice gruel containing no KGM (0%G), rice gruel supplemented with 0.4% KGM (0.4%G), and rice gruel supplemented with 0.8% KGM (0.8%G), every Sunday for 3 weeks. Blood samples were obtained at baseline and at 30, 60, and 120 min after ingestion to measure the abovementioned lipid parameters. Lipid parameters showed small, but significant, changes. Significant reductions were found in circulating FFA levels among all participants. Circulating TG levels significantly declined at 30 min and then remained nearly constant in the 0.8%G group but exhibited no significant difference in the 0%G and 0.4%G groups. Although circulating levels of LPL and GPIHBP1 significantly decreased in the 0%G and 0.4%G groups, they increased at 120 min in the 0.8%G group. Participants in the 0%G and 0.4%G groups showed significant decreases in circulating HTGL levels, which was not observed in the 0.8%G group. Our results demonstrate the novel pleiotropic effects of KGM. Supplementation of rice gruel with KGM powder led to TG reduction accompanied by LPL and GPIHBP1 elevation and HTGL stabilization, thereby attenuating TG metabolism. |
| first_indexed | 2024-03-10T10:03:18Z |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T10:03:18Z |
| publishDate | 2021-06-01 |
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| series | Nutrients |
| spelling | doaj.art-219a97415c184649a4813dd5911b15332023-11-22T01:45:29ZengMDPI AGNutrients2072-66432021-06-01137219110.3390/nu13072191Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance TestTakumi Nagasawa0Takao Kimura1Akihiro Yoshida2Katsuhiko Tsunekawa3Osamu Araki4Kazumi Ushiki5Hirotaka Ishigaki6Yoshifumi Shoho7Itsumi Suda8Suguru Hiramoto9Masami Murakami10Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanDepartment of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Showa-machi 3-39-22, Meabshi 371-8511, Gunma, JapanIn a recent study, we showed that konjac glucomannan (KGM) inhibits rice gruel-induced postprandial increases in plasma glucose and insulin levels. To extend this research, we investigated the effects of KGM addition to rice gruel on pre- and postprandial concentrations of circulating lipoprotein lipase (LPL), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), hepatic triglyceride lipase (HTGL), free fatty acids (FFA), and triglycerides (TG). A total of 13 Japanese men, without diabetes, dyslipidemia, or gastrointestinal diseases, interchangeably ingested rice gruel containing no KGM (0%G), rice gruel supplemented with 0.4% KGM (0.4%G), and rice gruel supplemented with 0.8% KGM (0.8%G), every Sunday for 3 weeks. Blood samples were obtained at baseline and at 30, 60, and 120 min after ingestion to measure the abovementioned lipid parameters. Lipid parameters showed small, but significant, changes. Significant reductions were found in circulating FFA levels among all participants. Circulating TG levels significantly declined at 30 min and then remained nearly constant in the 0.8%G group but exhibited no significant difference in the 0%G and 0.4%G groups. Although circulating levels of LPL and GPIHBP1 significantly decreased in the 0%G and 0.4%G groups, they increased at 120 min in the 0.8%G group. Participants in the 0%G and 0.4%G groups showed significant decreases in circulating HTGL levels, which was not observed in the 0.8%G group. Our results demonstrate the novel pleiotropic effects of KGM. Supplementation of rice gruel with KGM powder led to TG reduction accompanied by LPL and GPIHBP1 elevation and HTGL stabilization, thereby attenuating TG metabolism.https://www.mdpi.com/2072-6643/13/7/2191dietary supplementskonjac glucomannanrice grueltriglyceridelipoprotein lipase (LPL)glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) |
| spellingShingle | Takumi Nagasawa Takao Kimura Akihiro Yoshida Katsuhiko Tsunekawa Osamu Araki Kazumi Ushiki Hirotaka Ishigaki Yoshifumi Shoho Itsumi Suda Suguru Hiramoto Masami Murakami Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test Nutrients dietary supplements konjac glucomannan rice gruel triglyceride lipoprotein lipase (LPL) glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) |
| title | Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test |
| title_full | Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test |
| title_fullStr | Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test |
| title_full_unstemmed | Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test |
| title_short | Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test |
| title_sort | konjac glucomannan attenuated triglyceride metabolism during rice gruel tolerance test |
| topic | dietary supplements konjac glucomannan rice gruel triglyceride lipoprotein lipase (LPL) glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) |
| url | https://www.mdpi.com/2072-6643/13/7/2191 |
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