Plasminogen activator inhibitor-1 in the evolution of stroke
Fibrinolytic activity in the acute stroke was examined by monitoring the level of plasminogen activator inhibitor-1 (PAI-1), as one of the indicators of fibrinolytic activity. Given the role of PAI-1 in the processes of atherogenesis and thrombogenesis, plasma PAI-1 level was measured in 59 patients...
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2004-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2004/0370-81790406143J.pdf |
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| author | Jovanović Zagorka B. Ilić Mirka Zidverc-Trajković Jasna Pavlović Aleksandra M. Mijajlović Milija Šternić-Čovičković Nadežda Stanković Sanja Beslać-Bumbaširević Ljiljana G. Kostić Vladimir S. |
| author_facet | Jovanović Zagorka B. Ilić Mirka Zidverc-Trajković Jasna Pavlović Aleksandra M. Mijajlović Milija Šternić-Čovičković Nadežda Stanković Sanja Beslać-Bumbaširević Ljiljana G. Kostić Vladimir S. |
| author_sort | Jovanović Zagorka B. |
| collection | DOAJ |
| description | Fibrinolytic activity in the acute stroke was examined by monitoring the level of plasminogen activator inhibitor-1 (PAI-1), as one of the indicators of fibrinolytic activity. Given the role of PAI-1 in the processes of atherogenesis and thrombogenesis, plasma PAI-1 level was measured in 59 patients (up to 50 years of age) with atherothrombotic stroke (verified by computed tomography scanning or magnetic resonance imaging of brain) in the period from 12 to 24 hours (I analysis) and 30 days after the onset of stroke (II analysis); then, it was correlated with plasma PAI-1 level in the control group (57 healthy subjects), which was 2.86±0.70 U/ml. It was found that PAI-1 level was significantly higher in the acute stroke (I analysis: PAI-1 =4.10±1.40 U/ml, p<0.001; II analysis: PAI-1 =3.64+0.90 U/ml, p<0.001), while fibrinolytic activity was lower, especially on the first day from the stroke that was not completely increased even after 30 days. There was no difference in PAI-1 levels between the subgroups of patients with infarction and lacunar cerebral ischemia (p>0.05), as well as between females and males (p>0.05). Along with significantly increased fibrinogen level (4.65±1 g/l, in the controls - 2.83±0.64 g/l, p<0.001), significantly higher triglycerides (2.04±0.76 mmol/l, in the controls - 1.38+0.54 mmol/l, p<0.001) and lipoproteins(a) (0.405±0.29 g/l, in the controls -0.172±0.14 g/l, p<0.001) were found, correlating with higher plasma PAI-1 level in these patients. The increased plasma level of PAI-1 pointed to possibility of decreased fibrinolytic activity in pathogenesis of ischemie stroke, as well as, risk of reinsult, which had been the greatest after the onset of stroke and declined gradually within several weeks. |
| first_indexed | 2024-12-23T14:17:51Z |
| format | Article |
| id | doaj.art-219b5b3b878e4ab0aed2fc67c8ef3733 |
| institution | Directory Open Access Journal |
| issn | 0370-8179 |
| language | English |
| last_indexed | 2024-12-23T14:17:51Z |
| publishDate | 2004-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-219b5b3b878e4ab0aed2fc67c8ef37332022-12-21T17:43:52ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792004-01-011325-614314710.2298/SARH0406143JPlasminogen activator inhibitor-1 in the evolution of strokeJovanović Zagorka B.Ilić MirkaZidverc-Trajković JasnaPavlović Aleksandra M.Mijajlović MilijaŠternić-Čovičković NadeždaStanković SanjaBeslać-Bumbaširević Ljiljana G.Kostić Vladimir S.Fibrinolytic activity in the acute stroke was examined by monitoring the level of plasminogen activator inhibitor-1 (PAI-1), as one of the indicators of fibrinolytic activity. Given the role of PAI-1 in the processes of atherogenesis and thrombogenesis, plasma PAI-1 level was measured in 59 patients (up to 50 years of age) with atherothrombotic stroke (verified by computed tomography scanning or magnetic resonance imaging of brain) in the period from 12 to 24 hours (I analysis) and 30 days after the onset of stroke (II analysis); then, it was correlated with plasma PAI-1 level in the control group (57 healthy subjects), which was 2.86±0.70 U/ml. It was found that PAI-1 level was significantly higher in the acute stroke (I analysis: PAI-1 =4.10±1.40 U/ml, p<0.001; II analysis: PAI-1 =3.64+0.90 U/ml, p<0.001), while fibrinolytic activity was lower, especially on the first day from the stroke that was not completely increased even after 30 days. There was no difference in PAI-1 levels between the subgroups of patients with infarction and lacunar cerebral ischemia (p>0.05), as well as between females and males (p>0.05). Along with significantly increased fibrinogen level (4.65±1 g/l, in the controls - 2.83±0.64 g/l, p<0.001), significantly higher triglycerides (2.04±0.76 mmol/l, in the controls - 1.38+0.54 mmol/l, p<0.001) and lipoproteins(a) (0.405±0.29 g/l, in the controls -0.172±0.14 g/l, p<0.001) were found, correlating with higher plasma PAI-1 level in these patients. The increased plasma level of PAI-1 pointed to possibility of decreased fibrinolytic activity in pathogenesis of ischemie stroke, as well as, risk of reinsult, which had been the greatest after the onset of stroke and declined gradually within several weeks.http://www.doiserbia.nb.rs/img/doi/0370-8179/2004/0370-81790406143J.pdfstrokefibrinolysisPAI-1 |
| spellingShingle | Jovanović Zagorka B. Ilić Mirka Zidverc-Trajković Jasna Pavlović Aleksandra M. Mijajlović Milija Šternić-Čovičković Nadežda Stanković Sanja Beslać-Bumbaširević Ljiljana G. Kostić Vladimir S. Plasminogen activator inhibitor-1 in the evolution of stroke Srpski Arhiv za Celokupno Lekarstvo stroke fibrinolysis PAI-1 |
| title | Plasminogen activator inhibitor-1 in the evolution of stroke |
| title_full | Plasminogen activator inhibitor-1 in the evolution of stroke |
| title_fullStr | Plasminogen activator inhibitor-1 in the evolution of stroke |
| title_full_unstemmed | Plasminogen activator inhibitor-1 in the evolution of stroke |
| title_short | Plasminogen activator inhibitor-1 in the evolution of stroke |
| title_sort | plasminogen activator inhibitor 1 in the evolution of stroke |
| topic | stroke fibrinolysis PAI-1 |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2004/0370-81790406143J.pdf |
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