Non-invasive characterization of intracranial tumors by magnetic resonance elastography
Presurgical, non-invasive methods of differentiating brain tumors have remained unsatisfactory even for specialized academic hospitals. Despite major advances in clinical and neuroradiological diagnostic techniques, the majority of neurooncology patients still need to undergo a brain biopsy for diag...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOP Publishing
2013-01-01
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| Series: | New Journal of Physics |
| Online Access: | https://doi.org/10.1088/1367-2630/15/8/085024 |
| _version_ | 1797751422823956480 |
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| author | M Simon J Guo S Papazoglou H Scholand-Engler C Erdmann U Melchert M Bonsanto J Braun D Petersen I Sack J Wuerfel |
| author_facet | M Simon J Guo S Papazoglou H Scholand-Engler C Erdmann U Melchert M Bonsanto J Braun D Petersen I Sack J Wuerfel |
| author_sort | M Simon |
| collection | DOAJ |
| description | Presurgical, non-invasive methods of differentiating brain tumors have remained unsatisfactory even for specialized academic hospitals. Despite major advances in clinical and neuroradiological diagnostic techniques, the majority of neurooncology patients still need to undergo a brain biopsy for diagnosis. Recent single cell experiments suggested that biomechanical cell properties might be very sensitive in detecting cellular malignancy. Accordingly, we investigated magnetic resonance elastography (MRE) as an investigative tool for the clinical routine diagnostic work-up of intracranial neoplasm. In order to obtain sufficient spatial resolution for the biomechanical characterization of intracranial tumors, we modified a recently introduced least-squares solution of the stationary wave equation, facilitating stable solutions of the magnitude | G *| and the phase angle φ of the complex shear modulus G *. MRE was added to a routine diagnostic or presurgical neuroradiological magnetic resonance imaging work-up in 16 prospective patients and it was well tolerated in all cases. Our preliminary tumor MRE data revealed alterations in viscoelastic constants, e.g. a loss of stiffness in malignancies compared to healthy reference tissue, or benign variants. Based on larger studies on selected tumor entities to establish threshold and reference values for future diagnostic purposes, MRE may thus provide a predictive marker for tumor malignancy and thereby contribute to an early non-invasive clinical assessment of suspicious cerebral lesions. |
| first_indexed | 2024-03-12T16:48:17Z |
| format | Article |
| id | doaj.art-219b944fb88f432eacc8edb70390f22c |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:48:17Z |
| publishDate | 2013-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-219b944fb88f432eacc8edb70390f22c2023-08-08T11:27:09ZengIOP PublishingNew Journal of Physics1367-26302013-01-0115808502410.1088/1367-2630/15/8/085024Non-invasive characterization of intracranial tumors by magnetic resonance elastographyM Simon0J Guo1S Papazoglou2H Scholand-Engler3C Erdmann4U Melchert5M Bonsanto6J Braun7D Petersen8I Sack9J Wuerfel10Institute of Neuroradiology, University Luebeck , Ratzeburger Allee 140, D-23568 Lübeck, GermanyDepartment of Radiology, Charité University Medicine Berlin , Charitéplatz 1, D-10117 Berlin, GermanyDepartment of Radiology, Charité University Medicine Berlin , Charitéplatz 1, D-10117 Berlin, Germany; NeuroCure Clinical Research Center, Charité University Medicine Berlin , Charitéplatz 1, D-10117 Berlin, GermanyInstitute of Neuroradiology, University Luebeck , Ratzeburger Allee 140, D-23568 Lübeck, GermanyInstitute of Neuroradiology, University Luebeck , Ratzeburger Allee 140, D-23568 Lübeck, GermanyInstitute of Neuroradiology, University Luebeck , Ratzeburger Allee 140, D-23568 Lübeck, GermanyDepartment of Neurosurgery, University Medical Center Schleswig-Holstein , Campus Lübeck, Ratzeburger Allee 140, D-23568 Lübeck, GermanyInstitute of Medical Informatics, Charité University Medicine Berlin , Charitéplatz 1, D-10117 Berlin, GermanyInstitute of Neuroradiology, University Luebeck , Ratzeburger Allee 140, D-23568 Lübeck, GermanyDepartment of Radiology, Charité University Medicine Berlin , Charitéplatz 1, D-10117 Berlin, GermanyInstitute of Neuroradiology, University Luebeck , Ratzeburger Allee 140, D-23568 Lübeck, Germany; NeuroCure Clinical Research Center, Charité University Medicine Berlin , Charitéplatz 1, D-10117 Berlin, Germany; Institute of Neuroradiology, University Medical Center Göttingen , Robert-Koch-Str. 40, D-37075 Göttingen, GermanyPresurgical, non-invasive methods of differentiating brain tumors have remained unsatisfactory even for specialized academic hospitals. Despite major advances in clinical and neuroradiological diagnostic techniques, the majority of neurooncology patients still need to undergo a brain biopsy for diagnosis. Recent single cell experiments suggested that biomechanical cell properties might be very sensitive in detecting cellular malignancy. Accordingly, we investigated magnetic resonance elastography (MRE) as an investigative tool for the clinical routine diagnostic work-up of intracranial neoplasm. In order to obtain sufficient spatial resolution for the biomechanical characterization of intracranial tumors, we modified a recently introduced least-squares solution of the stationary wave equation, facilitating stable solutions of the magnitude | G *| and the phase angle φ of the complex shear modulus G *. MRE was added to a routine diagnostic or presurgical neuroradiological magnetic resonance imaging work-up in 16 prospective patients and it was well tolerated in all cases. Our preliminary tumor MRE data revealed alterations in viscoelastic constants, e.g. a loss of stiffness in malignancies compared to healthy reference tissue, or benign variants. Based on larger studies on selected tumor entities to establish threshold and reference values for future diagnostic purposes, MRE may thus provide a predictive marker for tumor malignancy and thereby contribute to an early non-invasive clinical assessment of suspicious cerebral lesions.https://doi.org/10.1088/1367-2630/15/8/085024 |
| spellingShingle | M Simon J Guo S Papazoglou H Scholand-Engler C Erdmann U Melchert M Bonsanto J Braun D Petersen I Sack J Wuerfel Non-invasive characterization of intracranial tumors by magnetic resonance elastography New Journal of Physics |
| title | Non-invasive characterization of intracranial tumors by magnetic resonance elastography |
| title_full | Non-invasive characterization of intracranial tumors by magnetic resonance elastography |
| title_fullStr | Non-invasive characterization of intracranial tumors by magnetic resonance elastography |
| title_full_unstemmed | Non-invasive characterization of intracranial tumors by magnetic resonance elastography |
| title_short | Non-invasive characterization of intracranial tumors by magnetic resonance elastography |
| title_sort | non invasive characterization of intracranial tumors by magnetic resonance elastography |
| url | https://doi.org/10.1088/1367-2630/15/8/085024 |
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