Premature birth carries a higher risk of nephrotic syndrome: a cohort study
Abstract The pathogenesis of nephrotic syndrome is unclear. We conducted a nationwide population-based cohort study to examine the associations between preterm births and subsequent development of NS. NS was defined as ≥ 3 records with ICD-9-CM codes for NS in hospital admission or outpatient clinic...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-00164-2 |
| _version_ | 1818919983139258368 |
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| author | Chih-Chia Chen Tsung Yu Hsin-Hsu Chou Yuan-Yow Chiou Pao-Lin Kuo |
| author_facet | Chih-Chia Chen Tsung Yu Hsin-Hsu Chou Yuan-Yow Chiou Pao-Lin Kuo |
| author_sort | Chih-Chia Chen |
| collection | DOAJ |
| description | Abstract The pathogenesis of nephrotic syndrome is unclear. We conducted a nationwide population-based cohort study to examine the associations between preterm births and subsequent development of NS. NS was defined as ≥ 3 records with ICD-9-CM codes for NS in hospital admission or outpatient clinic visits. To avoid secondary nephrotic syndrome or nephritis with nephrotic range proteinuria, especially IgA nephropathy, we excluded patients with associated codes. A total of 78,651 preterm infants (gestational age < 37 weeks) and 786,510 matched term infants born between 2004 and 2009 were enrolled and followed until 2016. In the unadjusted models, preterm births, maternal diabetes, and pregnancy induced hypertension were associated with subsequent NS. After adjustment, preterm births remained significantly associated with NS (p = 0.001). The risk of NS increased as the gestational age decreased (p for trend < 0.001). Among the NS population, preterm births were not associated with more complications (Hypertension: p = 0.19; Serious infections: p = 0.63, ESRD: p = 0.75) or a requirement for secondary immunosuppressants (p = 0.61). In conclusion, preterm births were associated with subsequent NS, where the risk increased as the gestational age decreased. Our study provides valuable information for future pathogenesis studies. |
| first_indexed | 2024-12-20T01:14:31Z |
| format | Article |
| id | doaj.art-219d67c3e09946f3809cf45191b165b9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T01:14:31Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-219d67c3e09946f3809cf45191b165b92022-12-21T19:58:37ZengNature PortfolioScientific Reports2045-23222021-10-0111111010.1038/s41598-021-00164-2Premature birth carries a higher risk of nephrotic syndrome: a cohort studyChih-Chia Chen0Tsung Yu1Hsin-Hsu Chou2Yuan-Yow Chiou3Pao-Lin Kuo4Institute of Clinical Medicine, College of Medicine, National Cheng Kung UniversityDepartment of Public Health, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung UniversityDepartment of Pediatrics, Ditmanson Medical Foundation, Chiayi Christian HospitalInstitute of Clinical Medicine, College of Medicine, National Cheng Kung UniversityDepartment of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung UniversityAbstract The pathogenesis of nephrotic syndrome is unclear. We conducted a nationwide population-based cohort study to examine the associations between preterm births and subsequent development of NS. NS was defined as ≥ 3 records with ICD-9-CM codes for NS in hospital admission or outpatient clinic visits. To avoid secondary nephrotic syndrome or nephritis with nephrotic range proteinuria, especially IgA nephropathy, we excluded patients with associated codes. A total of 78,651 preterm infants (gestational age < 37 weeks) and 786,510 matched term infants born between 2004 and 2009 were enrolled and followed until 2016. In the unadjusted models, preterm births, maternal diabetes, and pregnancy induced hypertension were associated with subsequent NS. After adjustment, preterm births remained significantly associated with NS (p = 0.001). The risk of NS increased as the gestational age decreased (p for trend < 0.001). Among the NS population, preterm births were not associated with more complications (Hypertension: p = 0.19; Serious infections: p = 0.63, ESRD: p = 0.75) or a requirement for secondary immunosuppressants (p = 0.61). In conclusion, preterm births were associated with subsequent NS, where the risk increased as the gestational age decreased. Our study provides valuable information for future pathogenesis studies.https://doi.org/10.1038/s41598-021-00164-2 |
| spellingShingle | Chih-Chia Chen Tsung Yu Hsin-Hsu Chou Yuan-Yow Chiou Pao-Lin Kuo Premature birth carries a higher risk of nephrotic syndrome: a cohort study Scientific Reports |
| title | Premature birth carries a higher risk of nephrotic syndrome: a cohort study |
| title_full | Premature birth carries a higher risk of nephrotic syndrome: a cohort study |
| title_fullStr | Premature birth carries a higher risk of nephrotic syndrome: a cohort study |
| title_full_unstemmed | Premature birth carries a higher risk of nephrotic syndrome: a cohort study |
| title_short | Premature birth carries a higher risk of nephrotic syndrome: a cohort study |
| title_sort | premature birth carries a higher risk of nephrotic syndrome a cohort study |
| url | https://doi.org/10.1038/s41598-021-00164-2 |
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