Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study
Abstract Background Coronavirus disease 2019 (COVID-19) is a pandemic caused by a newly discovered coronavirus. Although clinical manifestations of COVID-19 are mainly pulmonary, some patients have other systemic manifestations. This study aimed to describe the clinical finding and outcomes in Sudan...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Tropical Medicine and Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41182-021-00382-4 |
| _version_ | 1818824864891404288 |
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| author | Elfatih A. Hasabo Fatima A. Ayyad Sara A. M. Alam Eldeen Malaz K. Noureldaim Tibyan A. Abdallah Yousra T. Ahmed Safaa Badi Waleed K. Khalid Hind A. Mirghani Yossra A. Mohammed Lubaba A. Alkhider Saada A. Hamad Amna M. Tagelseed Ethar H. A. Elsheikh Noon H. Khalid Samia A. Mohammed Sara O. Elmobark Ola O. Ali Duaa A. Mohammed Ali Mohamed S. Muneer Heitham Awadalla Elfatih M. Malik |
| author_facet | Elfatih A. Hasabo Fatima A. Ayyad Sara A. M. Alam Eldeen Malaz K. Noureldaim Tibyan A. Abdallah Yousra T. Ahmed Safaa Badi Waleed K. Khalid Hind A. Mirghani Yossra A. Mohammed Lubaba A. Alkhider Saada A. Hamad Amna M. Tagelseed Ethar H. A. Elsheikh Noon H. Khalid Samia A. Mohammed Sara O. Elmobark Ola O. Ali Duaa A. Mohammed Ali Mohamed S. Muneer Heitham Awadalla Elfatih M. Malik |
| author_sort | Elfatih A. Hasabo |
| collection | DOAJ |
| description | Abstract Background Coronavirus disease 2019 (COVID-19) is a pandemic caused by a newly discovered coronavirus. Although clinical manifestations of COVID-19 are mainly pulmonary, some patients have other systemic manifestations. This study aimed to describe the clinical finding and outcomes in Sudanese patients diagnosed with COVID-19. Methods This retrospective observational study is based on documented files that included patients diagnosed with COVID-19 in seven selected hospitals inside Khartoum. Clinical manifestations, complications and outcomes were extracted from patients’ records using an extraction form designed for this study. Results Data of 243 patients diagnosed with COVID-19 were analyzed. The mean (SD) age in years was 55.8 (18.4). Out of 116 participants, 27 of them (23.3%) had severe disease, 15 (12.9%) were critically ill. 67.5% of patients were admitted to the hospital within 7 days from onset of symptoms; most of them were admitted to the wards (n = 140,72.5%). Fever (83.2%), cough (70.7%), and shortness of breath (69.2%) were the most commonly recorded clinical manifestations. Sepsis (9.8%) and acidosis (7.8%) were the most frequently reported complications. Death was the final outcome in 21.4% (56/243). Older age and presence of diabetes were found significantly associated with in-hospital death. The laboratory results showed high CRP in 85.6% (119/139), high ferritin in 88.9% (24/27), lactate dehydrogenase had a median of 409.0 (359–760), D-dimer had a median of 3.3 (1.2–16. 6), and 53/105 (50.5%) had low albumin. Conclusions Fever was the most mentioned sign among the participants, followed by fatigue. Cough and shortness of breath were the most commonly recorded pulmonary symptoms manifested. Our study showed multiple variables were associated with in-hospital death. The mortality rate was high among severe and critically ill patients diagnosed with COVID-19. |
| first_indexed | 2024-12-19T00:02:39Z |
| format | Article |
| id | doaj.art-219d7c2b33694239b83304b1ed0eaca7 |
| institution | Directory Open Access Journal |
| issn | 1349-4147 |
| language | English |
| last_indexed | 2024-12-19T00:02:39Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Tropical Medicine and Health |
| spelling | doaj.art-219d7c2b33694239b83304b1ed0eaca72022-12-21T20:46:24ZengBMCTropical Medicine and Health1349-41472021-11-0149111310.1186/s41182-021-00382-4Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational studyElfatih A. Hasabo0Fatima A. Ayyad1Sara A. M. Alam Eldeen2Malaz K. Noureldaim3Tibyan A. Abdallah4Yousra T. Ahmed5Safaa Badi6Waleed K. Khalid7Hind A. Mirghani8Yossra A. Mohammed9Lubaba A. Alkhider10Saada A. Hamad11Amna M. Tagelseed12Ethar H. A. Elsheikh13Noon H. Khalid14Samia A. Mohammed15Sara O. Elmobark16Ola O. Ali17Duaa A. Mohammed Ali18Mohamed S. Muneer19Heitham Awadalla20Elfatih M. Malik21Faculty of Medicine, University of KhartoumSchool of Medicine, Ahfad University for WomenFaculty of Medicine, University of KhartoumFaculty of Medicine, National Ribat UniversityFaculty of Medicine, University of KhartoumFaculty of Medical Laboratory, University of Alzaiem AlazhariFaculty of Pharmacy, Omdurman Islamic UniversitySudan Medical Specialization BoardSchool of Medicine, Ahfad University for WomenFederal Ministry of HealthFaculty of Medicine, University of KhartoumFaculty of Medicine, University of KhartoumFaculty of Medicine, University of KhartoumFaculty of Medicine, University of KhartoumFaculty of Medicine, University of KhartoumFaculty of Medicine, University of KhartoumFaculty of Medicine, University of KhartoumFaculty of Medicine, University of KhartoumFaculty of Medicine, University of KhartoumFaculty of Medicine, University of KhartoumDepartment of Community Medicine, Faculty of Medicine, University of KhartoumDepartment of Community Medicine, Faculty of Medicine, University of KhartoumAbstract Background Coronavirus disease 2019 (COVID-19) is a pandemic caused by a newly discovered coronavirus. Although clinical manifestations of COVID-19 are mainly pulmonary, some patients have other systemic manifestations. This study aimed to describe the clinical finding and outcomes in Sudanese patients diagnosed with COVID-19. Methods This retrospective observational study is based on documented files that included patients diagnosed with COVID-19 in seven selected hospitals inside Khartoum. Clinical manifestations, complications and outcomes were extracted from patients’ records using an extraction form designed for this study. Results Data of 243 patients diagnosed with COVID-19 were analyzed. The mean (SD) age in years was 55.8 (18.4). Out of 116 participants, 27 of them (23.3%) had severe disease, 15 (12.9%) were critically ill. 67.5% of patients were admitted to the hospital within 7 days from onset of symptoms; most of them were admitted to the wards (n = 140,72.5%). Fever (83.2%), cough (70.7%), and shortness of breath (69.2%) were the most commonly recorded clinical manifestations. Sepsis (9.8%) and acidosis (7.8%) were the most frequently reported complications. Death was the final outcome in 21.4% (56/243). Older age and presence of diabetes were found significantly associated with in-hospital death. The laboratory results showed high CRP in 85.6% (119/139), high ferritin in 88.9% (24/27), lactate dehydrogenase had a median of 409.0 (359–760), D-dimer had a median of 3.3 (1.2–16. 6), and 53/105 (50.5%) had low albumin. Conclusions Fever was the most mentioned sign among the participants, followed by fatigue. Cough and shortness of breath were the most commonly recorded pulmonary symptoms manifested. Our study showed multiple variables were associated with in-hospital death. The mortality rate was high among severe and critically ill patients diagnosed with COVID-19.https://doi.org/10.1186/s41182-021-00382-4COVID-19Clinical manifestationsIn-hospital outcomesComplicationsSudanSeverity |
| spellingShingle | Elfatih A. Hasabo Fatima A. Ayyad Sara A. M. Alam Eldeen Malaz K. Noureldaim Tibyan A. Abdallah Yousra T. Ahmed Safaa Badi Waleed K. Khalid Hind A. Mirghani Yossra A. Mohammed Lubaba A. Alkhider Saada A. Hamad Amna M. Tagelseed Ethar H. A. Elsheikh Noon H. Khalid Samia A. Mohammed Sara O. Elmobark Ola O. Ali Duaa A. Mohammed Ali Mohamed S. Muneer Heitham Awadalla Elfatih M. Malik Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study Tropical Medicine and Health COVID-19 Clinical manifestations In-hospital outcomes Complications Sudan Severity |
| title | Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study |
| title_full | Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study |
| title_fullStr | Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study |
| title_full_unstemmed | Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study |
| title_short | Clinical manifestations, complications, and outcomes of patients with COVID-19 in Sudan: a multicenter observational study |
| title_sort | clinical manifestations complications and outcomes of patients with covid 19 in sudan a multicenter observational study |
| topic | COVID-19 Clinical manifestations In-hospital outcomes Complications Sudan Severity |
| url | https://doi.org/10.1186/s41182-021-00382-4 |
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