A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal Cancer

A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal Cancer

<b>Background:</b> In colorectal cancer (CRC), mutations of genes associated with the TGF-β/BMP signaling pathway, particularly affecting <i>SMAD4</i>, are known to correlate with decreased overall survival and it is assumed that this signaling axis plays a key role in chemor...

Full description

Bibliographic Details
Main Authors: Ulrike Pfohl, Jürgen Loskutov, Sanum Bashir, Ralf Kühn, Patrick Herter, Markus Templin, Soulafa Mamlouk, Sergei Belanov, Michael Linnebacher, Florian Bürtin, Marcus Vetter, Christoph Reinhard, Lena Wedeken, Christian R. A. Regenbrecht
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
organoids
biomarker
targeted therapy
colorectal cancer
CRC
<i>SMAD4</i>
Online Access:https://www.mdpi.com/2072-6694/14/13/3252

Similar Items

Similar Items