In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells
Macrophage-derived foam cells play critical roles in the initiation and progression of atherosclerosis. Activated macrophages and foam cells are important biomarkers for targeted imaging and inflammatory disease therapy. Macrophages also express the dectin-1 receptor, which specifically recognizes β...
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Format: | Article |
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MDPI AG
2020-12-01
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Series: | International Journal of Molecular Sciences |
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Online Access: | https://www.mdpi.com/1422-0067/22/1/177 |
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author | Jae Won Ahn Jin Hyuk Kim Kyeongsoon Park |
author_facet | Jae Won Ahn Jin Hyuk Kim Kyeongsoon Park |
author_sort | Jae Won Ahn |
collection | DOAJ |
description | Macrophage-derived foam cells play critical roles in the initiation and progression of atherosclerosis. Activated macrophages and foam cells are important biomarkers for targeted imaging and inflammatory disease therapy. Macrophages also express the dectin-1 receptor, which specifically recognizes β-glucan (Glu). Here, we prepared photoactivatable nanoagents (termed Glu/Ce6 nanocomplexes) by encapsulating hydrophobic chlorin e6 (Ce6) within the triple-helix structure of Glu in aqueous condition. Glu/Ce6 nanocomplexes generate singlet oxygen upon laser irradiation. The Glu/Ce6 nanocomplexes were internalized into foam cells and delivered Ce6 molecules into the cytoplasm of foam cells. Upon laser irradiation, they induced significant membrane damage and apoptosis of foam cells. These results suggest that Glu/Ce6 nanocomplexes can be a photoactivatable material for treating atherogenic foam cells. |
first_indexed | 2024-03-10T13:45:14Z |
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id | doaj.art-219e0a2e301d4853ba8e57a96b5b87dd |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T13:45:14Z |
publishDate | 2020-12-01 |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-219e0a2e301d4853ba8e57a96b5b87dd2023-11-21T02:41:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-0122117710.3390/ijms22010177In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam CellsJae Won Ahn0Jin Hyuk Kim1Kyeongsoon Park2Department of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi 17546, KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi 17546, KoreaDepartment of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi 17546, KoreaMacrophage-derived foam cells play critical roles in the initiation and progression of atherosclerosis. Activated macrophages and foam cells are important biomarkers for targeted imaging and inflammatory disease therapy. Macrophages also express the dectin-1 receptor, which specifically recognizes β-glucan (Glu). Here, we prepared photoactivatable nanoagents (termed Glu/Ce6 nanocomplexes) by encapsulating hydrophobic chlorin e6 (Ce6) within the triple-helix structure of Glu in aqueous condition. Glu/Ce6 nanocomplexes generate singlet oxygen upon laser irradiation. The Glu/Ce6 nanocomplexes were internalized into foam cells and delivered Ce6 molecules into the cytoplasm of foam cells. Upon laser irradiation, they induced significant membrane damage and apoptosis of foam cells. These results suggest that Glu/Ce6 nanocomplexes can be a photoactivatable material for treating atherogenic foam cells.https://www.mdpi.com/1422-0067/22/1/177β-glucanchlorin e6dectin-1photodynamic therapyfoam cells |
spellingShingle | Jae Won Ahn Jin Hyuk Kim Kyeongsoon Park In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells International Journal of Molecular Sciences β-glucan chlorin e6 dectin-1 photodynamic therapy foam cells |
title | In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells |
title_full | In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells |
title_fullStr | In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells |
title_full_unstemmed | In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells |
title_short | In Vitro Photodynamic Effects of the Inclusion Nanocomplexes of Glucan and Chlorin e6 on Atherogenic Foam Cells |
title_sort | in vitro photodynamic effects of the inclusion nanocomplexes of glucan and chlorin e6 on atherogenic foam cells |
topic | β-glucan chlorin e6 dectin-1 photodynamic therapy foam cells |
url | https://www.mdpi.com/1422-0067/22/1/177 |
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