Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number
Background: Ambient particulate matter (PM) has been associated with mitochondrial damage and dysfunction caused by excessive oxidative stress, but the associations between long-term PM exposure and leukocyte mitochondrial DNA copy number (mtDNAcn), a biomarker of mitochondrial dysfunction due to ox...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020300982 |
| _version_ | 1818191654099615744 |
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| author | Xinmei Wang Jaime E. Hart Qisijing Liu Shaowei Wu Hongmei Nan Francine Laden |
| author_facet | Xinmei Wang Jaime E. Hart Qisijing Liu Shaowei Wu Hongmei Nan Francine Laden |
| author_sort | Xinmei Wang |
| collection | DOAJ |
| description | Background: Ambient particulate matter (PM) has been associated with mitochondrial damage and dysfunction caused by excessive oxidative stress, but the associations between long-term PM exposure and leukocyte mitochondrial DNA copy number (mtDNAcn), a biomarker of mitochondrial dysfunction due to oxidative stress, are less studied. Objectives: To investigate the associations between short-, intermediate- and long-term exposure (1-, 3- and 12-months) to different size fractions of PM (PM2.5, PM2.5-10 and PM10) and leukocyte mtDNAcn in a cross-sectional study. Methods: The associations between each of the PM exposure metrics with z scores of log-transformed mtDNAcn were examined using generalized linear regression models in 2758 female participants from the Nurses’ Health Study (NHS). Monthly exposures to PM were estimated from spatio-temporal prediction models matched to each participants’ address history. Potential effect modification by selected covariates was examined using multiplicative interaction terms and subgroup analyses. Results: In single-size fraction models, increases in all size fractions of PM were associated with decreases in mtDNAcn, although only models with longer averages of PM2.5 reached statistical significance. For example, an interquartile range (IQR) increase in 12-month average ambient PM2.5 (5.5 μg/m3) was associated with a 0.07 [95% confidence interval (95% CI): −0.13, −0.01; p-value = 0.02] decrease in mtDNAcn z score in both basic- and multivariable-adjusted models. Associations for PM2.5 were stronger after controlling for PM2.5-10 in two size-fraction models. Conclusions: Our study suggests that long-term exposure to ambient PM2.5 is associated with decreased mtDNAcn in healthy women. |
| first_indexed | 2024-12-12T00:18:02Z |
| format | Article |
| id | doaj.art-21a0d9be7a374a118467db66e1ce283c |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-12T00:18:02Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-21a0d9be7a374a118467db66e1ce283c2022-12-22T00:44:48ZengElsevierEnvironment International0160-41202020-08-01141105761Association of particulate matter air pollution with leukocyte mitochondrial DNA copy numberXinmei Wang0Jaime E. Hart1Qisijing Liu2Shaowei Wu3Hongmei Nan4Francine Laden5Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USADepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences, Peking University, Ministry of Education, China; Corresponding author at: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, 38 Xueyuan Road, Haidian, Beijing, China.Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USAChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USABackground: Ambient particulate matter (PM) has been associated with mitochondrial damage and dysfunction caused by excessive oxidative stress, but the associations between long-term PM exposure and leukocyte mitochondrial DNA copy number (mtDNAcn), a biomarker of mitochondrial dysfunction due to oxidative stress, are less studied. Objectives: To investigate the associations between short-, intermediate- and long-term exposure (1-, 3- and 12-months) to different size fractions of PM (PM2.5, PM2.5-10 and PM10) and leukocyte mtDNAcn in a cross-sectional study. Methods: The associations between each of the PM exposure metrics with z scores of log-transformed mtDNAcn were examined using generalized linear regression models in 2758 female participants from the Nurses’ Health Study (NHS). Monthly exposures to PM were estimated from spatio-temporal prediction models matched to each participants’ address history. Potential effect modification by selected covariates was examined using multiplicative interaction terms and subgroup analyses. Results: In single-size fraction models, increases in all size fractions of PM were associated with decreases in mtDNAcn, although only models with longer averages of PM2.5 reached statistical significance. For example, an interquartile range (IQR) increase in 12-month average ambient PM2.5 (5.5 μg/m3) was associated with a 0.07 [95% confidence interval (95% CI): −0.13, −0.01; p-value = 0.02] decrease in mtDNAcn z score in both basic- and multivariable-adjusted models. Associations for PM2.5 were stronger after controlling for PM2.5-10 in two size-fraction models. Conclusions: Our study suggests that long-term exposure to ambient PM2.5 is associated with decreased mtDNAcn in healthy women.http://www.sciencedirect.com/science/article/pii/S0160412020300982Air pollutionLeukocyteMitochondrial DNA copy numberOxidative stressParticulate matterPM2.5 |
| spellingShingle | Xinmei Wang Jaime E. Hart Qisijing Liu Shaowei Wu Hongmei Nan Francine Laden Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number Environment International Air pollution Leukocyte Mitochondrial DNA copy number Oxidative stress Particulate matter PM2.5 |
| title | Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number |
| title_full | Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number |
| title_fullStr | Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number |
| title_full_unstemmed | Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number |
| title_short | Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number |
| title_sort | association of particulate matter air pollution with leukocyte mitochondrial dna copy number |
| topic | Air pollution Leukocyte Mitochondrial DNA copy number Oxidative stress Particulate matter PM2.5 |
| url | http://www.sciencedirect.com/science/article/pii/S0160412020300982 |
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