The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study
Montmorency tart cherries (MC) have been found to modulate indices of vascular function with interventions of varying duration. The objective of this preliminary study was to identify the chronic effects of MC supplementation on vascular function and the potential for urinary metabolomics to provide...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2021-01-01
|
| Series: | Journal of Nutritional Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679021000689/type/journal_article |
| _version_ | 1811155968366477312 |
|---|---|
| author | Rachel Kimble Lucy Murray Karen M. Keane Karen Haggerty Glyn Howatson John K. Lodge |
| author_facet | Rachel Kimble Lucy Murray Karen M. Keane Karen Haggerty Glyn Howatson John K. Lodge |
| author_sort | Rachel Kimble |
| collection | DOAJ |
| description | Montmorency tart cherries (MC) have been found to modulate indices of vascular function with interventions of varying duration. The objective of this preliminary study was to identify the chronic effects of MC supplementation on vascular function and the potential for urinary metabolomics to provide mechanistic evidence. We performed a placebo-controlled, double-blind, randomised study on 23 healthy individuals (18M, 7F) that consumed 30 ml MC or a placebo twice daily for 28 days. Whole body measures of vascular function and spot urine collections were taken at baseline and after supplementation. There were no significant changes to vascular function including blood pressure and arterial stiffness. Urinary metabolite profiling highlighted significant changes (P < 0⋅001) with putative discriminatory metabolites related to tryptophan and histidine metabolism. Overall, MC supplementation for 28 days does not improve indices of vascular function but changes to the urinary metabolome could be suggestive of potential mechanisms. |
| first_indexed | 2024-04-10T04:42:33Z |
| format | Article |
| id | doaj.art-21a13beef875445e8fc89362d49c1cb3 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:42:33Z |
| publishDate | 2021-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-21a13beef875445e8fc89362d49c1cb32023-03-09T12:38:45ZengCambridge University PressJournal of Nutritional Science2048-67902021-01-011010.1017/jns.2021.68The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot studyRachel Kimble0Lucy Murray1Karen M. Keane2Karen Haggerty3Glyn Howatson4John K. Lodge5https://orcid.org/0000-0001-6014-4952Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UKDepartment of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UKDepartment of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UKDepartment of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UKDepartment of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UKDepartment of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UKMontmorency tart cherries (MC) have been found to modulate indices of vascular function with interventions of varying duration. The objective of this preliminary study was to identify the chronic effects of MC supplementation on vascular function and the potential for urinary metabolomics to provide mechanistic evidence. We performed a placebo-controlled, double-blind, randomised study on 23 healthy individuals (18M, 7F) that consumed 30 ml MC or a placebo twice daily for 28 days. Whole body measures of vascular function and spot urine collections were taken at baseline and after supplementation. There were no significant changes to vascular function including blood pressure and arterial stiffness. Urinary metabolite profiling highlighted significant changes (P < 0⋅001) with putative discriminatory metabolites related to tryptophan and histidine metabolism. Overall, MC supplementation for 28 days does not improve indices of vascular function but changes to the urinary metabolome could be suggestive of potential mechanisms.https://www.cambridge.org/core/product/identifier/S2048679021000689/type/journal_articleAnthocyaninArterial stiffnessBlood pressureCherryMetabolomics |
| spellingShingle | Rachel Kimble Lucy Murray Karen M. Keane Karen Haggerty Glyn Howatson John K. Lodge The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study Journal of Nutritional Science Anthocyanin Arterial stiffness Blood pressure Cherry Metabolomics |
| title | The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study |
| title_full | The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study |
| title_fullStr | The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study |
| title_full_unstemmed | The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study |
| title_short | The influence of tart cherries (Prunus Cerasus) on vascular function and the urinary metabolome: a randomised placebo-controlled pilot study |
| title_sort | influence of tart cherries prunus cerasus on vascular function and the urinary metabolome a randomised placebo controlled pilot study |
| topic | Anthocyanin Arterial stiffness Blood pressure Cherry Metabolomics |
| url | https://www.cambridge.org/core/product/identifier/S2048679021000689/type/journal_article |
| work_keys_str_mv | AT rachelkimble theinfluenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT lucymurray theinfluenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT karenmkeane theinfluenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT karenhaggerty theinfluenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT glynhowatson theinfluenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT johnklodge theinfluenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT rachelkimble influenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT lucymurray influenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT karenmkeane influenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT karenhaggerty influenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT glynhowatson influenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy AT johnklodge influenceoftartcherriesprunuscerasusonvascularfunctionandtheurinarymetabolomearandomisedplacebocontrolledpilotstudy |