Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision
Toshiyuki Takemori,1 Teruya Kawamoto,1,2 Hitomi Hara,1 Naomasa Fukase,1 Shuichi Fujiwara,1 Kazumichi Kitayama,1 Shunsuke Yahiro,1 Tomohiro Miyamoto,1 Yutaka Mifune,1 Yuichi Hoshino,1 Kenichiro Kakutani,1 Tomoyuki Matsumoto,1 Takehiko Matsushita,1 Takahiro Niikura,1 Ryosuke Kuroda,1 Toshihiro Akisue1...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-05-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/clinical-outcomes-and-prognostic-factors-in-soft-tissue-sarcoma-patien-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1817980870592561152 |
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| author | Takemori T Kawamoto T Hara H Fukase N Fujiwara S Kitayama K Yahiro S Miyamoto T Mifune Y Hoshino Y Kakutani K Matsumoto T Matsushita T Niikura T Kuroda R Akisue T |
| author_facet | Takemori T Kawamoto T Hara H Fukase N Fujiwara S Kitayama K Yahiro S Miyamoto T Mifune Y Hoshino Y Kakutani K Matsumoto T Matsushita T Niikura T Kuroda R Akisue T |
| author_sort | Takemori T |
| collection | DOAJ |
| description | Toshiyuki Takemori,1 Teruya Kawamoto,1,2 Hitomi Hara,1 Naomasa Fukase,1 Shuichi Fujiwara,1 Kazumichi Kitayama,1 Shunsuke Yahiro,1 Tomohiro Miyamoto,1 Yutaka Mifune,1 Yuichi Hoshino,1 Kenichiro Kakutani,1 Tomoyuki Matsumoto,1 Takehiko Matsushita,1 Takahiro Niikura,1 Ryosuke Kuroda,1 Toshihiro Akisue1,3 1Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan; 2Division of Orthopaedic Surgery, Kobe University Hospital International Clinical Cancer Research Center, Kobe, Japan; 3Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, JapanCorrespondence: Teruya Kawamoto, Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan, Tel +81-783825985, Fax +81-783516944, Email trykwmt@med.kobe-u.ac.jpPurpose: Soft tissue sarcomas (STSs) constitute a group of rare, heterogeneous tumors representing approximately 1% of all cancers. Owing to the rarity and pathological diversity of the disease, unplanned excision (UE) has often been performed for STS, resulting in an unfavorable prognosis. This study aimed to clarify clinical outcomes and prognostic factors in STS patients who underwent UE.Patients and Methods: In a retrospective review of the medical records of patients with STS who underwent surgery at our institution between 1999 and 2015, patients were enrolled to either a UE group or a planned excision (PE) group. An analysis was then conducted to identify factors associated with prognosis after UE.Results: Of 134 patients undergoing surgery for STS, 110 were enrolled to the PE group and 24 to the UE group. The median size of the primary tumor was significantly smaller, and more lesions were located in the superficial layer in the UE group than in the PE group. In addition, plastic reconstruction after additional radical resection was required significantly more often in the UE group than in the PE group. No significant difference in overall survival, local recurrence-free survival, or disease-free survival (DFS) between the UE and PE groups was observed; however, metastasis-free survival was significantly better in the UE group. In the UE group, poorer DFS was associated with older age (≥ 61 years) and a larger primary tumor (≥ 2.9 cm).Conclusion: A prognosis similar to that in patients undergoing PE could be achieved by appropriate additional surgeries in patients initially undergoing UE. However, UE for STS should be avoided, especially in older patients and those with a larger primary tumor.Keywords: unplanned excision, soft tissue sarcoma, survival, prognostic factor |
| first_indexed | 2024-04-13T22:58:25Z |
| format | Article |
| id | doaj.art-21a212afc8c842ef89d17dd43d7e16f9 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-13T22:58:25Z |
| publishDate | 2022-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-21a212afc8c842ef89d17dd43d7e16f92022-12-22T02:25:55ZengDove Medical PressCancer Management and Research1179-13222022-05-01Volume 141815182475537Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned ExcisionTakemori TKawamoto THara HFukase NFujiwara SKitayama KYahiro SMiyamoto TMifune YHoshino YKakutani KMatsumoto TMatsushita TNiikura TKuroda RAkisue TToshiyuki Takemori,1 Teruya Kawamoto,1,2 Hitomi Hara,1 Naomasa Fukase,1 Shuichi Fujiwara,1 Kazumichi Kitayama,1 Shunsuke Yahiro,1 Tomohiro Miyamoto,1 Yutaka Mifune,1 Yuichi Hoshino,1 Kenichiro Kakutani,1 Tomoyuki Matsumoto,1 Takehiko Matsushita,1 Takahiro Niikura,1 Ryosuke Kuroda,1 Toshihiro Akisue1,3 1Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan; 2Division of Orthopaedic Surgery, Kobe University Hospital International Clinical Cancer Research Center, Kobe, Japan; 3Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, JapanCorrespondence: Teruya Kawamoto, Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan, Tel +81-783825985, Fax +81-783516944, Email trykwmt@med.kobe-u.ac.jpPurpose: Soft tissue sarcomas (STSs) constitute a group of rare, heterogeneous tumors representing approximately 1% of all cancers. Owing to the rarity and pathological diversity of the disease, unplanned excision (UE) has often been performed for STS, resulting in an unfavorable prognosis. This study aimed to clarify clinical outcomes and prognostic factors in STS patients who underwent UE.Patients and Methods: In a retrospective review of the medical records of patients with STS who underwent surgery at our institution between 1999 and 2015, patients were enrolled to either a UE group or a planned excision (PE) group. An analysis was then conducted to identify factors associated with prognosis after UE.Results: Of 134 patients undergoing surgery for STS, 110 were enrolled to the PE group and 24 to the UE group. The median size of the primary tumor was significantly smaller, and more lesions were located in the superficial layer in the UE group than in the PE group. In addition, plastic reconstruction after additional radical resection was required significantly more often in the UE group than in the PE group. No significant difference in overall survival, local recurrence-free survival, or disease-free survival (DFS) between the UE and PE groups was observed; however, metastasis-free survival was significantly better in the UE group. In the UE group, poorer DFS was associated with older age (≥ 61 years) and a larger primary tumor (≥ 2.9 cm).Conclusion: A prognosis similar to that in patients undergoing PE could be achieved by appropriate additional surgeries in patients initially undergoing UE. However, UE for STS should be avoided, especially in older patients and those with a larger primary tumor.Keywords: unplanned excision, soft tissue sarcoma, survival, prognostic factorhttps://www.dovepress.com/clinical-outcomes-and-prognostic-factors-in-soft-tissue-sarcoma-patien-peer-reviewed-fulltext-article-CMARunplanned excisionsoft tissue sarcomasurvivalprognostic factor |
| spellingShingle | Takemori T Kawamoto T Hara H Fukase N Fujiwara S Kitayama K Yahiro S Miyamoto T Mifune Y Hoshino Y Kakutani K Matsumoto T Matsushita T Niikura T Kuroda R Akisue T Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision Cancer Management and Research unplanned excision soft tissue sarcoma survival prognostic factor |
| title | Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision |
| title_full | Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision |
| title_fullStr | Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision |
| title_full_unstemmed | Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision |
| title_short | Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision |
| title_sort | clinical outcomes and prognostic factors in soft tissue sarcoma patients after unplanned excision |
| topic | unplanned excision soft tissue sarcoma survival prognostic factor |
| url | https://www.dovepress.com/clinical-outcomes-and-prognostic-factors-in-soft-tissue-sarcoma-patien-peer-reviewed-fulltext-article-CMAR |
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