Antidiabetic Effect of Salvianolic Acid A on Diabetic Animal Models via AMPK Activation and Mitochondrial Regulation

Antidiabetic Effect of Salvianolic Acid A on Diabetic Animal Models via AMPK Activation and Mitochondrial Regulation

Background/Aims: Diabetes mellitus (DM) characterized by hyperglycemia contributes to macrovascular and microvascular complications. Salvianolic acid A (SalA) is a polyphenolic compound isolated from the root of Salvia miltiorrhiza Bunge, which is a traditional Chinese medicine widely used to treat...

Full description

Bibliographic Details
Main Authors:	Guifen Qiang, Xiuying Yang, Lili Shi, Hengai Zhang, Bainian Chen, Yan Zhao, Mian Zu, Dan Zhou, Jing Guo, Haiguang Yang, Li Zhang, Guanhua Du
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Salvianolic acid A Diabetes mellitus Antidiabetic Mitochondria AMPK ATP Mitochondrial membrane potential
Online Access:	http://www.karger.com/Article/FullText/430258

Similar Items

Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1α-Sirt3 Axis
by: Guanhua Du, et al.
Published: (2012-09-01)

Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway
by: Jialin Sun, et al.
Published: (2022-12-01)

Salvianolic Acid B Ameliorates Hyperglycemia and Dyslipidemia in db/db Mice through the AMPK Pathway
by: Ming-Qing Huang, et al.
Published: (2016-12-01)

Salvianolic Acid A Ameliorates Arsenic Trioxide-Induced Cardiotoxicity Through Decreasing Cardiac Mitochondrial Injury and Promotes Its Anticancer Activity
by: Jing-yi Zhang, et al.
Published: (2018-05-01)

AMPK Signaling Regulates Mitophagy and Mitochondrial ATP Production in Human Trophoblast Cell Line BeWo
by: Bin Wu, et al.
Published: (2022-04-01)

Cardio-protective effects of salvianolic acid B on oxygen and glucose deprivation (OGD)-treated H9c2 cells
by: Bin Yang, et al.
Published: (2019-12-01)

EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway
by: Shoubao Wang, et al.
Published: (2013-02-01)

Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy
by: Di-fei Gong, et al.
Published: (2023-04-01)

Salvianolic acids for injection alleviates cerebral ischemia-induced neurodegeneration by inhibiting endoplasmic reticulum stress and neuroinflammation
by: Wen Zhang, et al.
Published: (2023-03-01)

Salvianolic Acid A Protects Against Diabetic Nephropathy through Ameliorating Glomerular Endothelial Dysfunction via Inhibiting AGE-RAGE Signaling
by: Biyu Hou, et al.
Published: (2017-12-01)

Salvianolic acid D: A potent molecule that protects against heart failure induced by hypertension via Ras signalling pathway and PI3K/Akt signalling pathway
by: Kai Chen, et al.
Published: (2023-02-01)

Berberine and Its Study as an Antidiabetic Compound
by: Ayudiah Rizki Utami, et al.
Published: (2023-07-01)

Inhibition of Tanshinone IIA, Salvianolic Acid A and Salvianolic Acid B on Areca Nut Extract-Induced Oral Submucous Fibrosis in Vitro
by: Jian-Ping Dai, et al.
Published: (2015-04-01)

Inhibition of ASC enhances the protective role of salvianolic acid A in traumatic brain injury via inhibition of inflammation and recovery of mitochondrial function
by: Jing Wang, et al.
Published: (2021-03-01)

Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation
by: Tianxia Li, et al.
Published: (2020-06-01)

Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1/AMPK signaling pathway
by: Na Li, et al.
Published: (2023-09-01)

AMPK, Mitochondrial Function, and Cardiovascular Disease
by: Shengnan Wu, et al.
Published: (2020-07-01)

Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice
by: Liu Y, et al.
Published: (2016-08-01)

Salvianolic acids and its potential for cardio-protection against myocardial ischemic reperfusion injury in diabetes
by: Yuxin Jiang, et al.
Published: (2024-01-01)

Irisin Attenuates Myocardial Ischemia/Reperfusion Injury and Improves Mitochondrial Function Through AMPK Pathway in Diabetic Mice
by: Chao Xin, et al.
Published: (2020-09-01)

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans
by: Yue Zhang, et al.
Published: (2019-08-01)

Salvianolic acid B alleviates diabetic endothelial and mitochondrial dysfunction by down-regulating apoptosis and mitophagy of endothelial cells
by: Jie Xiang, et al.
Published: (2022-02-01)

Linking ROS Levels to Autophagy: The Key Role of AMPK
by: Francesco Agostini, et al.
Published: (2023-07-01)

AMPKα1 Deficiency in Astrocytes from a Rat Model of ALS Is Associated with an Altered Metabolic Resilience
by: Inês Belo do Nascimento, et al.
Published: (2023-07-01)

Preparation and Certification of a New Salvianolic Acid A Reference Material for Food and Drug Research
by: Dezhi Yang, et al.
Published: (2020-04-01)

Comparison of Salvianolic Acid A Adsorption by Phenylboronic-Acid-Functionalized Montmorillonites with Different Intercalators
by: Jun Qian, et al.
Published: (2023-07-01)

Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo
by: Yifan Wu, et al.
Published: (2020-06-01)

5,6-dehydrokawain improves glycaemic control by modulating AMPK target genes in Drosophila with a high-sucrose diet-induced hyperglycaemia
by: Hadiza Muhammad Maiturare, et al.
Published: (2022-05-01)

Salvianolic acid B promotes angiogenesis and inhibits cardiomyocyte apoptosis by regulating autophagy in myocardial ischemia
by: Qi Chen, et al.
Published: (2023-11-01)

Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage
by: Zhun Xiao, et al.
Published: (2020-11-01)

AMPK-Targeted Effector Networks in Mycobacterial Infection
by: Eun-Kyeong Jo, et al.
Published: (2019-03-01)

Salvianolic acid B alleviates LPS-induced acute lung injury in mice
by: LI Yu-ting, LUO Le, YIN Su-juan, ZHU Xiao-lan
Published: (2021-03-01)

Phycocyanin Protects against High Glucose High Fat Diet Induced Diabetes in Mice and Participates in AKT and AMPK Signaling
by: Shuai Hao, et al.
Published: (2022-10-01)

Salvianolic Acid B Significantly Suppresses the Migration of Melanoma Cells via Direct Interaction with β-Actin
by: Ying Zhang, et al.
Published: (2024-02-01)

Electroacupuncture Ameliorates Depression-Like Behaviors in Post-Stroke Rats via Activating AMPK-Mediated Mitochondrial Function
by: Ding Z, et al.
Published: (2023-12-01)

Salvianolic acid B: In vitro and in vivo effects on the immune system
by: Vujičić Milica, et al.
Published: (2017-01-01)

Salvianolic Acid A Inhibits PDGF-BB Induced Vascular Smooth Muscle Cell Migration and Proliferation While Does Not Constrain Endothelial Cell Proliferation and Nitric Oxide Biosynthesis
by: Chao Huang, et al.
Published: (2012-03-01)

Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice
by: Yihuang Lin, et al.
Published: (2017-03-01)

Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
by: Urszula Szwedowicz, et al.
Published: (2021-07-01)

Integrative Omics Analyses Reveal the Effects of Copper Ions on Salvianolic Acid Biosynthesis
by: Yaping Xiang, et al.
Published: (2021-10-01)