Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications
Tissue engineering (TE) combines cells, scaffolds, and growth factors to assemble functional tissues for repair or replacement of tissues and organs. Cardiac TE is focused on developing cardiac cells, tissues, and structures—most notably the heart. This review presents the requirements, challenges,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/7/3/105 |
| _version_ | 1797554393220907008 |
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| author | Taylor Cook Suh Alaowei Y. Amanah Jessica M. Gluck |
| author_facet | Taylor Cook Suh Alaowei Y. Amanah Jessica M. Gluck |
| author_sort | Taylor Cook Suh |
| collection | DOAJ |
| description | Tissue engineering (TE) combines cells, scaffolds, and growth factors to assemble functional tissues for repair or replacement of tissues and organs. Cardiac TE is focused on developing cardiac cells, tissues, and structures—most notably the heart. This review presents the requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) towards applications to TE hearts. Electrospinning is an attractive fabrication method for cardiac TE scaffolds because it produces fibers that demonstrate the optimal potential for mimicking the complex structure of the cardiac extracellular matrix (ECM). iPSCs theoretically offer the capacity to generate limitless numbers of CMs for use in TE hearts, however these iPSC-CMs are electrophysiologically, morphologically, mechanically, and metabolically immature compared to adult CMs. This presents a functional limitation to their use in cardiac TE, and research aiming to address this limitation is presented in this review. |
| first_indexed | 2024-03-10T16:31:29Z |
| format | Article |
| id | doaj.art-21a4b5942a024cc9bbb410937c6cb9a4 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T16:31:29Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-21a4b5942a024cc9bbb410937c6cb9a42023-11-20T12:46:27ZengMDPI AGBioengineering2306-53542020-09-017310510.3390/bioengineering7030105Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering ApplicationsTaylor Cook Suh0Alaowei Y. Amanah1Jessica M. Gluck2Textile Engineering, Chemistry and Science Department, Wilson College of Textiles, NC State University, Raleigh, NC 27695, USATextile Engineering, Chemistry and Science Department, Wilson College of Textiles, NC State University, Raleigh, NC 27695, USATextile Engineering, Chemistry and Science Department, Wilson College of Textiles, NC State University, Raleigh, NC 27695, USATissue engineering (TE) combines cells, scaffolds, and growth factors to assemble functional tissues for repair or replacement of tissues and organs. Cardiac TE is focused on developing cardiac cells, tissues, and structures—most notably the heart. This review presents the requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) towards applications to TE hearts. Electrospinning is an attractive fabrication method for cardiac TE scaffolds because it produces fibers that demonstrate the optimal potential for mimicking the complex structure of the cardiac extracellular matrix (ECM). iPSCs theoretically offer the capacity to generate limitless numbers of CMs for use in TE hearts, however these iPSC-CMs are electrophysiologically, morphologically, mechanically, and metabolically immature compared to adult CMs. This presents a functional limitation to their use in cardiac TE, and research aiming to address this limitation is presented in this review.https://www.mdpi.com/2306-5354/7/3/105tissue engineeringcardiac tissue engineeringengineered heart tissueelectrospinningscaffoldscardiomyocytes |
| spellingShingle | Taylor Cook Suh Alaowei Y. Amanah Jessica M. Gluck Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications Bioengineering tissue engineering cardiac tissue engineering engineered heart tissue electrospinning scaffolds cardiomyocytes |
| title | Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications |
| title_full | Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications |
| title_fullStr | Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications |
| title_full_unstemmed | Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications |
| title_short | Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications |
| title_sort | electrospun scaffolds and induced pluripotent stem cell derived cardiomyocytes for cardiac tissue engineering applications |
| topic | tissue engineering cardiac tissue engineering engineered heart tissue electrospinning scaffolds cardiomyocytes |
| url | https://www.mdpi.com/2306-5354/7/3/105 |
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