Metabolic and functional cardiac changes at II-type pancreatic diabetes and abdominal adiposity in rats
Investigation of pathogenetic correlation of abdominal adisposity and II-type pancreatic diabetes (PD) has been made with the aim to reveal the importance of carbohydrate metabolism disturbances at above said pathology combination in cardiac abnormalities. 30 white alley rats at the age of 8-12 mont...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2003-09-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3773 |
| Summary: | Investigation of pathogenetic correlation of abdominal adisposity and II-type pancreatic diabetes (PD) has been made with the aim to reveal the importance of carbohydrate metabolism disturbances at above said pathology combination in cardiac abnormalities. 30 white alley rats at the age of 8-12 months have been included into the experimental group. Control group has been formed of 30 animals. Used methods of investigation: simulation of II-type PD in rats with streptozotocin and study of carbohydrate metabolism indices in entire organism as well as contractile function indices and indices of isolated and contracting heart metabolism. As a result it has been revealed that the weight of rats with II-type PD and abdominal adisposity, the level of glucose and glycated haemoglobin in blood, of lactate and pyruvate had been increased surely. The normal level of blood serum C-peptide has confirmed the absence of mass death of β-cells. The hearts taken from diabetic animals have responded to the increase of contraction frequency with the decrease of advanced pressure, i.e. the negative inotropic effect has been observed. Therefore the peripheral insulin resistance plays the leading role in the development of metabolic and functional abnormality complex at II-type PD and abdominal adisposity. Accumulation of lactate, metabolic acidosis, decrease of glucose efficiency and dysfunction of cardiac hystiocyte calcium pump with the development of diastolic myocardium dysfunction contribute to the development of metabolic disturbances. |
|---|---|
| ISSN: | 1682-0363 1819-3684 |