The interaction of platelet-related factors with tumor cells promotes tumor metastasis
Abstract Platelets not only participate in thrombosis and hemostasis but also interact with tumor cells and protect them from mechanical damage caused by hemodynamic shear stress and natural killer cell lysis, thereby promoting their colonization and metastasis to distant organs. Platelets can affec...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-05126-6 |
| _version_ | 1797199172912283648 |
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| author | Jie Xue Jianzhao Deng Hongwei Qin Songxia Yan Zhen Zhao Lifeng Qin Jiao Liu Haiyan Wang |
| author_facet | Jie Xue Jianzhao Deng Hongwei Qin Songxia Yan Zhen Zhao Lifeng Qin Jiao Liu Haiyan Wang |
| author_sort | Jie Xue |
| collection | DOAJ |
| description | Abstract Platelets not only participate in thrombosis and hemostasis but also interact with tumor cells and protect them from mechanical damage caused by hemodynamic shear stress and natural killer cell lysis, thereby promoting their colonization and metastasis to distant organs. Platelets can affect the tumor microenvironment via interactions between platelet-related factors and tumor cells. Metastasis is a key event in cancer-related death and is associated with platelet-related factors in lung, breast, and colorectal cancers. Although the factors that promote platelet expression vary slightly in terms of their type and mode of action, they all contribute to the overall process. Recognizing the correlation and mechanisms between these factors is crucial for studying the colonization of distant target organs and developing targeted therapies for these three types of tumors. This paper reviews studies on major platelet-related factors closely associated with metastasis in lung, breast, and colorectal cancers. |
| first_indexed | 2024-04-24T07:11:32Z |
| format | Article |
| id | doaj.art-21a6e84e487b4cebb3c94bd3c79ed983 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-24T07:11:32Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-21a6e84e487b4cebb3c94bd3c79ed9832024-04-21T11:28:36ZengBMCJournal of Translational Medicine1479-58762024-04-0122111310.1186/s12967-024-05126-6The interaction of platelet-related factors with tumor cells promotes tumor metastasisJie Xue0Jianzhao Deng1Hongwei Qin2Songxia Yan3Zhen Zhao4Lifeng Qin5Jiao Liu6Haiyan Wang7Department of Blood Transfusion, The Affiliated Hospital of Qingdao UniversityClinical Laboratory, The Central Hospital of Qingdao JiaozhouDepartment of Blood Transfusion, The Central Hospital of Qingdao JiaozhouDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao UniversityDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao UniversityDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao UniversityDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao UniversityDepartment of Blood Transfusion, The Affiliated Hospital of Qingdao UniversityAbstract Platelets not only participate in thrombosis and hemostasis but also interact with tumor cells and protect them from mechanical damage caused by hemodynamic shear stress and natural killer cell lysis, thereby promoting their colonization and metastasis to distant organs. Platelets can affect the tumor microenvironment via interactions between platelet-related factors and tumor cells. Metastasis is a key event in cancer-related death and is associated with platelet-related factors in lung, breast, and colorectal cancers. Although the factors that promote platelet expression vary slightly in terms of their type and mode of action, they all contribute to the overall process. Recognizing the correlation and mechanisms between these factors is crucial for studying the colonization of distant target organs and developing targeted therapies for these three types of tumors. This paper reviews studies on major platelet-related factors closely associated with metastasis in lung, breast, and colorectal cancers.https://doi.org/10.1186/s12967-024-05126-6PlateletPlatelet-related factorsTumor metastasisTumor microenvironmentLung cancerBreast cancer |
| spellingShingle | Jie Xue Jianzhao Deng Hongwei Qin Songxia Yan Zhen Zhao Lifeng Qin Jiao Liu Haiyan Wang The interaction of platelet-related factors with tumor cells promotes tumor metastasis Journal of Translational Medicine Platelet Platelet-related factors Tumor metastasis Tumor microenvironment Lung cancer Breast cancer |
| title | The interaction of platelet-related factors with tumor cells promotes tumor metastasis |
| title_full | The interaction of platelet-related factors with tumor cells promotes tumor metastasis |
| title_fullStr | The interaction of platelet-related factors with tumor cells promotes tumor metastasis |
| title_full_unstemmed | The interaction of platelet-related factors with tumor cells promotes tumor metastasis |
| title_short | The interaction of platelet-related factors with tumor cells promotes tumor metastasis |
| title_sort | interaction of platelet related factors with tumor cells promotes tumor metastasis |
| topic | Platelet Platelet-related factors Tumor metastasis Tumor microenvironment Lung cancer Breast cancer |
| url | https://doi.org/10.1186/s12967-024-05126-6 |
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