How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography—A Review of the Literature and Proposed Multistep Approach
Non-alcoholic fatty liver disease (NAFLD), and its progressive form, non-alcoholic steatohepatitis (NASH), represent, nowadays, real challenges for the healthcare system. Liver fibrosis is the most important prognostic factor for NAFLD, and advanced fibrosis is associated with higher liver-related m...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/4/788 |
| _version_ | 1797621419615453184 |
|---|---|
| author | Madalina-Gabriela Taru Lidia Neamti Vlad Taru Lucia Maria Procopciuc Bogdan Procopet Monica Lupsor-Platon |
| author_facet | Madalina-Gabriela Taru Lidia Neamti Vlad Taru Lucia Maria Procopciuc Bogdan Procopet Monica Lupsor-Platon |
| author_sort | Madalina-Gabriela Taru |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD), and its progressive form, non-alcoholic steatohepatitis (NASH), represent, nowadays, real challenges for the healthcare system. Liver fibrosis is the most important prognostic factor for NAFLD, and advanced fibrosis is associated with higher liver-related mortality rates. Therefore, the key issues in NAFLD are the differentiation of NASH from simple steatosis and identification of advanced hepatic fibrosis. We critically reviewed the ultrasound (US) elastography techniques for the quantitative characterization of fibrosis, steatosis, and inflammation in NAFLD and NASH, with a specific focus on how to differentiate advanced fibrosis in adult patients. Vibration-controlled transient elastography (VCTE) is still the most utilized and validated elastography method for liver fibrosis assessment. The recently developed point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) techniques that use multiparametric approaches could bring essential improvements to diagnosis and risk stratification. |
| first_indexed | 2024-03-11T08:56:36Z |
| format | Article |
| id | doaj.art-21a6eeb8244744b0b4262f2672135e63 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T08:56:36Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-21a6eeb8244744b0b4262f2672135e632023-11-16T20:03:00ZengMDPI AGDiagnostics2075-44182023-02-0113478810.3390/diagnostics13040788How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography—A Review of the Literature and Proposed Multistep ApproachMadalina-Gabriela Taru0Lidia Neamti1Vlad Taru2Lucia Maria Procopciuc3Bogdan Procopet4Monica Lupsor-Platon5Hepatology Department, Regional Institute of Gastroenterology and Hepatology “Octavian Fodor”, 400162 Cluj-Napoca, RomaniaHepatology Department, Regional Institute of Gastroenterology and Hepatology “Octavian Fodor”, 400162 Cluj-Napoca, RomaniaHepatology Department, Regional Institute of Gastroenterology and Hepatology “Octavian Fodor”, 400162 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaHepatology Department, Regional Institute of Gastroenterology and Hepatology “Octavian Fodor”, 400162 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaNon-alcoholic fatty liver disease (NAFLD), and its progressive form, non-alcoholic steatohepatitis (NASH), represent, nowadays, real challenges for the healthcare system. Liver fibrosis is the most important prognostic factor for NAFLD, and advanced fibrosis is associated with higher liver-related mortality rates. Therefore, the key issues in NAFLD are the differentiation of NASH from simple steatosis and identification of advanced hepatic fibrosis. We critically reviewed the ultrasound (US) elastography techniques for the quantitative characterization of fibrosis, steatosis, and inflammation in NAFLD and NASH, with a specific focus on how to differentiate advanced fibrosis in adult patients. Vibration-controlled transient elastography (VCTE) is still the most utilized and validated elastography method for liver fibrosis assessment. The recently developed point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) techniques that use multiparametric approaches could bring essential improvements to diagnosis and risk stratification.https://www.mdpi.com/2075-4418/13/4/788non-alcoholic fatty liver diseasenon-alcoholic steatohepatitisultrasound elastographyvibration-controlled transient elastographypoint shear wave elastographytwo-dimensional shear wave elastography |
| spellingShingle | Madalina-Gabriela Taru Lidia Neamti Vlad Taru Lucia Maria Procopciuc Bogdan Procopet Monica Lupsor-Platon How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography—A Review of the Literature and Proposed Multistep Approach Diagnostics non-alcoholic fatty liver disease non-alcoholic steatohepatitis ultrasound elastography vibration-controlled transient elastography point shear wave elastography two-dimensional shear wave elastography |
| title | How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography—A Review of the Literature and Proposed Multistep Approach |
| title_full | How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography—A Review of the Literature and Proposed Multistep Approach |
| title_fullStr | How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography—A Review of the Literature and Proposed Multistep Approach |
| title_full_unstemmed | How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography—A Review of the Literature and Proposed Multistep Approach |
| title_short | How to Identify Advanced Fibrosis in Adult Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) Using Ultrasound Elastography—A Review of the Literature and Proposed Multistep Approach |
| title_sort | how to identify advanced fibrosis in adult patients with non alcoholic fatty liver disease nafld and non alcoholic steatohepatitis nash using ultrasound elastography a review of the literature and proposed multistep approach |
| topic | non-alcoholic fatty liver disease non-alcoholic steatohepatitis ultrasound elastography vibration-controlled transient elastography point shear wave elastography two-dimensional shear wave elastography |
| url | https://www.mdpi.com/2075-4418/13/4/788 |
| work_keys_str_mv | AT madalinagabrielataru howtoidentifyadvancedfibrosisinadultpatientswithnonalcoholicfattyliverdiseasenafldandnonalcoholicsteatohepatitisnashusingultrasoundelastographyareviewoftheliteratureandproposedmultistepapproach AT lidianeamti howtoidentifyadvancedfibrosisinadultpatientswithnonalcoholicfattyliverdiseasenafldandnonalcoholicsteatohepatitisnashusingultrasoundelastographyareviewoftheliteratureandproposedmultistepapproach AT vladtaru howtoidentifyadvancedfibrosisinadultpatientswithnonalcoholicfattyliverdiseasenafldandnonalcoholicsteatohepatitisnashusingultrasoundelastographyareviewoftheliteratureandproposedmultistepapproach AT luciamariaprocopciuc howtoidentifyadvancedfibrosisinadultpatientswithnonalcoholicfattyliverdiseasenafldandnonalcoholicsteatohepatitisnashusingultrasoundelastographyareviewoftheliteratureandproposedmultistepapproach AT bogdanprocopet howtoidentifyadvancedfibrosisinadultpatientswithnonalcoholicfattyliverdiseasenafldandnonalcoholicsteatohepatitisnashusingultrasoundelastographyareviewoftheliteratureandproposedmultistepapproach AT monicalupsorplaton howtoidentifyadvancedfibrosisinadultpatientswithnonalcoholicfattyliverdiseasenafldandnonalcoholicsteatohepatitisnashusingultrasoundelastographyareviewoftheliteratureandproposedmultistepapproach |