Baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal NOAC trials
The data report details the baseline characteristics and observed outcomes among patients included in a large US administrative claims database (Optum Labs Data Warehouse) and those enrolled in the pivotal phase III clinical trials examining apixaban, dabigratan, edoxaban and rivaroxaban versus warf...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-10-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340917303876 |
| _version_ | 1818290848660455424 |
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| author | Peter A. Noseworthy Xiaoxi Yao Bernard J. Gersh Ian Hargraves Nilay D. Shah Victor M. Montori |
| author_facet | Peter A. Noseworthy Xiaoxi Yao Bernard J. Gersh Ian Hargraves Nilay D. Shah Victor M. Montori |
| author_sort | Peter A. Noseworthy |
| collection | DOAJ |
| description | The data report details the baseline characteristics and observed outcomes among patients included in a large US administrative claims database (Optum Labs Data Warehouse) and those enrolled in the pivotal phase III clinical trials examining apixaban, dabigratan, edoxaban and rivaroxaban versus warfarin for the prevention of cardio embolism (Granger et al., 2011; Cannolly et al., 2009; Patel et al., 2011; Giugliano et al., 2013) [1–4]. These data are to be interpreted in the context of the linked publication (Noseworthy et al., 2017) [5]. These data illustrate baseline characteristics in patients treated in routine practice and those enrolled in clinical trials. For instance, patients treated with apixaban in practice tended to be slightly older and we more likely to be female than those enrolled in the apixaban clinical trial. Patient treated with rivaroxaban in practice tended to have lower CHADS2 scores than those included in the rivaroxaban clinical trial. Overall, and stratified by baseline CHADS2 scores, patients treated with NOACs in routine practice had comparable or slightly lower stroke risks than those in the clinical trials. Patients treated with NOACs in routine practice had slightly higher bleeding risk in practice, particularly in high-risk patients with CHADS2 ≥ 3, compared to those in the clinical trials. These data may serve as a benchmark for realized outcomes among anticoagulated patients with atrial fibrillation in the United States and may serve as a useful comparison to other datasets or countries. |
| first_indexed | 2024-12-13T02:34:42Z |
| format | Article |
| id | doaj.art-21a8458d598b4fa1a83c6bd6780a3d16 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-13T02:34:42Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-21a8458d598b4fa1a83c6bd6780a3d162022-12-22T00:02:26ZengElsevierData in Brief2352-34092017-10-0114C56356510.1016/j.dib.2017.08.010Baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal NOAC trialsPeter A. Noseworthy0Xiaoxi Yao1Bernard J. Gersh2Ian Hargraves3Nilay D. Shah4Victor M. Montori5Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, United StatesRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United StatesHeart Rhythm Section, Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United StatesKnowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, United StatesKnowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, United StatesRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United StatesThe data report details the baseline characteristics and observed outcomes among patients included in a large US administrative claims database (Optum Labs Data Warehouse) and those enrolled in the pivotal phase III clinical trials examining apixaban, dabigratan, edoxaban and rivaroxaban versus warfarin for the prevention of cardio embolism (Granger et al., 2011; Cannolly et al., 2009; Patel et al., 2011; Giugliano et al., 2013) [1–4]. These data are to be interpreted in the context of the linked publication (Noseworthy et al., 2017) [5]. These data illustrate baseline characteristics in patients treated in routine practice and those enrolled in clinical trials. For instance, patients treated with apixaban in practice tended to be slightly older and we more likely to be female than those enrolled in the apixaban clinical trial. Patient treated with rivaroxaban in practice tended to have lower CHADS2 scores than those included in the rivaroxaban clinical trial. Overall, and stratified by baseline CHADS2 scores, patients treated with NOACs in routine practice had comparable or slightly lower stroke risks than those in the clinical trials. Patients treated with NOACs in routine practice had slightly higher bleeding risk in practice, particularly in high-risk patients with CHADS2 ≥ 3, compared to those in the clinical trials. These data may serve as a benchmark for realized outcomes among anticoagulated patients with atrial fibrillation in the United States and may serve as a useful comparison to other datasets or countries.http://www.sciencedirect.com/science/article/pii/S2352340917303876 |
| spellingShingle | Peter A. Noseworthy Xiaoxi Yao Bernard J. Gersh Ian Hargraves Nilay D. Shah Victor M. Montori Baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal NOAC trials Data in Brief |
| title | Baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal NOAC trials |
| title_full | Baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal NOAC trials |
| title_fullStr | Baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal NOAC trials |
| title_full_unstemmed | Baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal NOAC trials |
| title_short | Baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal NOAC trials |
| title_sort | baseline characteristics and event rates among anticoagulated patients with atrial fibrillation in practice and pivotal noac trials |
| url | http://www.sciencedirect.com/science/article/pii/S2352340917303876 |
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