Relationship between Abnormal Placenta and Obstetric Outcomes: A Meta-Analysis
The placenta has several crucial physiological functions that help maintain a normal pregnancy. Although approximately 2–4% of pregnancies are complicated by abnormal placentas, obstetric outcomes remain understudied. This study aimed to determine the outcomes and prevalence of patients with abnorma...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/6/1522 |
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| author | Shinya Matsuzaki Yutaka Ueda Satoko Matsuzaki Hitomi Sakaguchi Mamoru Kakuda Misooja Lee Yuki Takemoto Harue Hayashida Michihide Maeda Reisa Kakubari Tsuyoshi Hisa Seiji Mabuchi Shoji Kamiura |
| author_facet | Shinya Matsuzaki Yutaka Ueda Satoko Matsuzaki Hitomi Sakaguchi Mamoru Kakuda Misooja Lee Yuki Takemoto Harue Hayashida Michihide Maeda Reisa Kakubari Tsuyoshi Hisa Seiji Mabuchi Shoji Kamiura |
| author_sort | Shinya Matsuzaki |
| collection | DOAJ |
| description | The placenta has several crucial physiological functions that help maintain a normal pregnancy. Although approximately 2–4% of pregnancies are complicated by abnormal placentas, obstetric outcomes remain understudied. This study aimed to determine the outcomes and prevalence of patients with abnormal placentas by conducting a systematic review of 48 studies published between 1974 and 2022. The cumulative prevalence of circumvallate placenta, succenturiate placenta, multilobed placenta, and placenta membranacea were 1.2%, 1.0%, 0.2%, and 0.004%, respectively. Pregnancies with a circumvallate placenta were associated with an increased rate of emergent cesarean delivery, preterm birth (PTB), and placental abruption compared to those without a circumvallate placenta. The succenturiate lobe of the placenta was associated with a higher rate of emergent cesarean delivery, whereas comparative results were observed in terms of PTB, placental abruption, and placenta previa in comparison to those without a succenturiate lobe of the placenta. A comparator study that examined the outcomes of multilobed placentas found that this data is usually unavailable. Patient-level analysis (<i>n</i> = 15) showed high-rates of abortion (40%), placenta accreta spectrum (40%), and a low term delivery rate (13.3%) in women with placenta membranacea. Although the current evidence is insufficient to draw a robust conclusion, abnormal placentas should be recognized as a high-risk factor for adverse outcomes during pregnancy. |
| first_indexed | 2024-03-11T02:44:27Z |
| format | Article |
| id | doaj.art-21a9dccf109647b5a93f6dc29959fff3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T02:44:27Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-21a9dccf109647b5a93f6dc29959fff32023-11-18T09:24:33ZengMDPI AGBiomedicines2227-90592023-05-01116152210.3390/biomedicines11061522Relationship between Abnormal Placenta and Obstetric Outcomes: A Meta-AnalysisShinya Matsuzaki0Yutaka Ueda1Satoko Matsuzaki2Hitomi Sakaguchi3Mamoru Kakuda4Misooja Lee5Yuki Takemoto6Harue Hayashida7Michihide Maeda8Reisa Kakubari9Tsuyoshi Hisa10Seiji Mabuchi11Shoji Kamiura12Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, JapanDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Obstetrics and Gynecology, Osaka General Medical Center, Osaka 558-8558, JapanDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Forensic Medicine, School of Medicine, Kindai University, Osaka 589-8511, JapanDepartment of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, JapanDepartment of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, JapanDepartment of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, JapanDepartment of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, JapanDepartment of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, JapanDepartment of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, JapanDepartment of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, JapanThe placenta has several crucial physiological functions that help maintain a normal pregnancy. Although approximately 2–4% of pregnancies are complicated by abnormal placentas, obstetric outcomes remain understudied. This study aimed to determine the outcomes and prevalence of patients with abnormal placentas by conducting a systematic review of 48 studies published between 1974 and 2022. The cumulative prevalence of circumvallate placenta, succenturiate placenta, multilobed placenta, and placenta membranacea were 1.2%, 1.0%, 0.2%, and 0.004%, respectively. Pregnancies with a circumvallate placenta were associated with an increased rate of emergent cesarean delivery, preterm birth (PTB), and placental abruption compared to those without a circumvallate placenta. The succenturiate lobe of the placenta was associated with a higher rate of emergent cesarean delivery, whereas comparative results were observed in terms of PTB, placental abruption, and placenta previa in comparison to those without a succenturiate lobe of the placenta. A comparator study that examined the outcomes of multilobed placentas found that this data is usually unavailable. Patient-level analysis (<i>n</i> = 15) showed high-rates of abortion (40%), placenta accreta spectrum (40%), and a low term delivery rate (13.3%) in women with placenta membranacea. Although the current evidence is insufficient to draw a robust conclusion, abnormal placentas should be recognized as a high-risk factor for adverse outcomes during pregnancy.https://www.mdpi.com/2227-9059/11/6/1522abnormal placentacircumvallate placentabilobed placentasuccenturiate lobeplacenta membranaceamultilobed placenta |
| spellingShingle | Shinya Matsuzaki Yutaka Ueda Satoko Matsuzaki Hitomi Sakaguchi Mamoru Kakuda Misooja Lee Yuki Takemoto Harue Hayashida Michihide Maeda Reisa Kakubari Tsuyoshi Hisa Seiji Mabuchi Shoji Kamiura Relationship between Abnormal Placenta and Obstetric Outcomes: A Meta-Analysis Biomedicines abnormal placenta circumvallate placenta bilobed placenta succenturiate lobe placenta membranacea multilobed placenta |
| title | Relationship between Abnormal Placenta and Obstetric Outcomes: A Meta-Analysis |
| title_full | Relationship between Abnormal Placenta and Obstetric Outcomes: A Meta-Analysis |
| title_fullStr | Relationship between Abnormal Placenta and Obstetric Outcomes: A Meta-Analysis |
| title_full_unstemmed | Relationship between Abnormal Placenta and Obstetric Outcomes: A Meta-Analysis |
| title_short | Relationship between Abnormal Placenta and Obstetric Outcomes: A Meta-Analysis |
| title_sort | relationship between abnormal placenta and obstetric outcomes a meta analysis |
| topic | abnormal placenta circumvallate placenta bilobed placenta succenturiate lobe placenta membranacea multilobed placenta |
| url | https://www.mdpi.com/2227-9059/11/6/1522 |
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