Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

Inhibitory Effect of Alpha-Mangostin to Dengue Virus Replication and Cytokines Expression in Human Peripheral Blood Mononuclear Cells

Abstract Massive pro-inflammatory cytokines production has been correlated with the pathogenesis of severe dengue disease. The active compound of mangosteen fruit pericarps, α-mangostin, has been commonly used as traditional medicine and dietary supplement. We examined the effect of α-mangostin agai...

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Bibliographic Details
Main Authors: Zaenal Sugiyanto, Benediktus Yohan, Soeharyo Hadisaputro, Edi Dharmana, Catharina Suharti, Winarto, Kis Djamiatun, Fifin L. Rahmi, R. Tedjo Sasmono
Format: Article
Language:English
Published: SpringerOpen 2019-09-01
Series:Natural Products and Bioprospecting
Subjects:
Dengue
Antiviral
Mangostin
Cytokine
PBMC
Online Access:http://link.springer.com/article/10.1007/s13659-019-00218-z

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